A New Norsesquiterpenoid from a Bornean Soft Coral Genus Nephthea

Ishii, Takahiro; Matsuura, Hiroshi; Zhan, Zhaoqi; Vairappan, Charles Santhanaraju

doi:10.3390/molecules14114591

Cited by 17 publications

(13 citation statements)

References 18 publications

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“…led to the identification of a new sterol (Fig 8), 4α-methyl-ergosta-6,8(14),22E-triene-3β-ol (98), a new sesquiterpenoid 1-acetoxy-germacra-5,10(14)-diene-4-one (99) and a cembrane diterpene, 6-acetoxy-7,8-epoxynephthenol acetate (100) together with the known compound epoxynephthenol acetate [4,[43][44]. [45].…”

Section: Nephthea Chabroliimentioning

confidence: 99%

Chemical Constituents and Biological Properties of the Marine Soft Coral <em>Nephthea</em>: A Review (Part 2)

Amir¹,

Koay²,

Yam³

2012

Trop. J. Pharm Res

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Section: Nephthea Chabroliimentioning

confidence: 99%

Chemical Constituents and Biological Properties of the Marine Soft Coral <em>Nephthea</em>: A Review (Part 2)

Amir¹,

Koay²,

Yam³

2012

Trop. J. Pharm Res

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“…Soft coral derived secondary metabolites are reported to exhibit promising biological activities such as anti-tumor, antiviral, antifouling and anti-inflammation [2]. Our previous chemical investigation on the soft coral genus Nephthea led to isolation and structural elucidation of a new cembrane diterpene [3], a new sterol [4] and a new norsesquiterpenoid [5], along with several known compounds [5]. However, there were no sesquiterpenes isolated from Bornean soft coral genus Capnella .…”

Section: Introductionmentioning

confidence: 99%

Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp.

Phan

Kim

et al. 2015

Marine Drugs

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Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulation of the LPS-induced pro-inflammatory IL-1β and NO production by down-regulating the expression of iNOS protein in RAW 264.7 macrophages.

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“…is one of the soft coral organisms that produce terpenoid compounds, a class of natural products, which have a wide range of pharmaceutical properties, such as cytotoxicity to cancer cell lines, antiviral, or anti-inflammatory. [1][2][3][4][5][6] However, the cytotoxic activity may vary from the same Nephthea spp. collected from different locations.…”

Section: Introductionmentioning

confidence: 99%

LC-MS metabolomic analysis of environmental stressor impacts on the metabolite diversity in Nephthea spp.

Januar¹,

Marraskuranto²,

Patantis³

et al. 2012

Chron Young Sci

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 57  LC-MS metabolomic analysis of environmental stressor impacts on the metabolite diversity in Nephthea spp.Abstract Context: The soft coral Nephthea spp. is a source of terpenoid class that potentially has pharmaceutical properties. However, metabolite diversity and cytotoxic activity of this species are varied among coral reefs from various sites. Aim: To analyze the water quality in Nephthea spp. environment as a possible factor causing a difference in its metabolite diversity. Settings and Design: Nephthea spp. from seven sites were taken in October 2010 at the Alor District of Marine Protected Area, Indonesia. Materials and Methods: Water quality assessment was analyzed in situ and indexed by Canadian Council of Ministry Environment-Water Quality Index (CCME-WQI) method. Meanwhile, metabolite diversity was analyzed by a LC-MS metabolomic method, using C18 reversed phase and gradient water-acetonitrile system. Statistical Analysis Used: Spearman's rho and regression analysis were applied to correlate the water quality index to ecological index (richness, diversity, and evenness) from LC-MS results. Results: The water quality index had a significant positive correlation and strong linear regression determinant to the total metabolite (R 2 = 0.704), particularly to semipolar metabolite richness (R 2 = 0.809), the area of terpenoid class in the organism. Conclusion: It can be concluded that water quality may serve as a major factor that affects the amount of richness in Nephthea spp. metabolites. When the water quality is lower, as environment stresses increases, it may affect the metabolite richness within direct disrupt of metabolite biosynthesis or indirect ecological means. Terpenoids are known as a soft coral antipredator (coral fishes), the amount of which depends on the water quality.

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A New Norsesquiterpenoid from a Bornean Soft Coral Genus Nephthea

Abstract: A new germacrane-type norsesquiterpenoid, 1-acetoxy-germacra-5E,10(14)-diene-4-one (1), as well as three known compounds, were isolated from the organic extracts of a Bornean soft coral Nephthea sp. Their structures were elucidated on the basis of spectroscopic data analysis.

Cited by 17 publications

References 18 publications

Chemical Constituents and Biological Properties of the Marine Soft Coral <em>Nephthea</em>: A Review (Part 2)

Chemical Constituents and Biological Properties of the Marine Soft Coral <em>Nephthea</em>: A Review (Part 2)

Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp.

LC-MS metabolomic analysis of environmental stressor impacts on the metabolite diversity in Nephthea spp.

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