A New Noroleanane from the Seeds of Trichosanthes kirilowii

Abstract

A new noroleanane named as karounitriol (1), together with four known compounds, 7-oxodihydrokarounidiol (2), isokarounidiol (3), karounidiol (4), and stigmasta-7,22-dien-3-ol were isolated from the seeds of Trichosanthes kirilowii Maxim. Structure of the new compound was elucidated as 3α,7β,29trihydroxy-D:C-friedo-olean-8-ene on the basis of spectroscopic methods including extensive 1D NMR (1 H, 13 C), 2D NMR (1 H-1 H COSY, DEPT, HMQC, HMBC, and NOESY), IR, and MS studies.

Chemical constituents of the genus Trichosanthes (Cucurbitaceae) and their biological activities: A review

“…Four cycloartane triterpenoids (46-49) have been isolated from T. kirilowii [30] and T. tricuspidata [31], whereas twenty-one pentacyclic triterpenoids (50-70) have been isolated from T. cucumerina, T. cucumeroides, T. dioica, T. kirilowii and T. truncata (Fig. 3) [19,20,[32][33][34][35][36][37][38][39][40]. Some of these compounds were evaluated for their biological activities.…”