Chemical constituents of the genus Trichosanthes (Cucurbitaceae) and their biological activities: A review

Pabuprapap, Wachirachai; Suksamrarn, Apichart

doi:10.2306/scienceasia1513-1874.2021.s012

Cited by 1 publication

(1 citation statement)

References 53 publications

(75 reference statements)

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“…Phytochemistry studies of XBCQ are limited, although the chemical compositions of the component herbs Dahuang [229], Kuxingren [230], and Gualou [231] and the mineral medicine Shigao (CaSO 4 •2H 2 O) have been widely investigated and defined. Pharmacokinetic studies of XBCQ are also limited.…”

Section: Xuanbai Chengqi Decoctionmentioning

confidence: 99%

Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics

Cheng

2021

IJMS

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Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection; the pathophysiology of sepsis is complex. The incidence of sepsis is steadily increasing, with worldwide mortality ranging between 30% and 50%. Current treatment approaches mainly rely on the timely and appropriate administration of antimicrobials and supportive therapies, but the search for pharmacotherapies modulating the host response has been unsuccessful. Chinese herbal medicines, i.e., Chinese patent medicines, Chinese herbal prescriptions, and single Chinese herbs, play an important role in the treatment of sepsis through multicomponent, multipathway, and multitargeting abilities and have been officially recommended for the management of COVID-19. Chinese herbal medicines have therapeutic actions promising for the treatment of sepsis; basic scientific research on these medicines is increasing. However, the material bases of most Chinese herbal medicines and their underlying mechanisms of action have not yet been fully elucidated. This review summarizes the current studies of Chinese herbal medicines used for the treatment of sepsis in terms of clinical efficacy and safety, pharmacological activity, phytochemistry, bioactive constituents, mechanisms of action, and pharmacokinetics, to provide an important foundation for clarifying the pathogenesis of sepsis and developing novel antisepsis drugs based on Chinese herbal medicines.

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Section: Xuanbai Chengqi Decoctionmentioning

confidence: 99%

Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics

Cheng

2021

IJMS

View full text Add to dashboard Cite

show abstract

Chemical constituents of the genus Trichosanthes (Cucurbitaceae) and their biological activities: A review

Cited by 1 publication

References 53 publications

Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics

Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics

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