A New Myohaptic Instrument to Assess Wrist Motion Dynamically

Manto, Mario; Braber, N. Van Den; Grimaldi, Giuliana; Lammertse, Piet

doi:10.3390/s100403180

Cited by 11 publications

(8 citation statements)

References 30 publications

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“…Indeed, hypermetria is larger when inertial loads are added to the moving hand, as a consequence of the inability to adequately tune the intensity of the antagonist activity. Cerebellar patients may also show impairments in the adaptation to external damping during fast reversal movements [133]. Dysmetria may be associated with a kinetic tremor, which predominates in visually guided tasks performed at slow or moderate velocities.…”

Section: Dysfunction Of Voluntary Limb Movements In Cerebellar Patienmentioning

confidence: 99%

Consensus Paper: Roles of the Cerebellum in Motor Control—The Diversity of Ideas on Cerebellar Involvement in Movement

Manto¹,

et al. 2011

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Considerable progress has been made in developing models of cerebellar function in sensorimotor control, as well as in identifying key problems that are the focus of current investigation. In this consensus paper, we discuss the literature on the role of the cerebellar circuitry in motor control, bringing together a range of different viewpoints. The following topics are covered: oculomotor control, classical conditioning (evidence in animals and in humans), cerebellar control of motor speech, control of grip forces, control of voluntary limb movements, timing, sensorimotor synchronization, control of corticomotor excitability, control of movement-related sensory data acquisition, cerebro-cerebellar interaction in visuokinesthetic perception of hand movement, functional neuroimaging studies, and magnetoencephalographic mapping of cortico-cerebellar dynamics. While the field has yet to reach a consensus on the precise role played by the cerebellum in movement control, the literature has witnessed the emergence of broad proposals that address cerebellar function at multiple levels of analysis. This paper highlights the diversity of current opinion, providing a framework for debate and discussion on the role of this quintessential vertebrate structure.

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Section: Dysfunction Of Voluntary Limb Movements In Cerebellar Patienmentioning

confidence: 99%

Consensus Paper: Roles of the Cerebellum in Motor Control—The Diversity of Ideas on Cerebellar Involvement in Movement

Manto¹,

et al. 2011

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“…The cerebellum would estimate and predict the movement dynamics of the body and inform the cerebral cortex in particular via the dentato-thalamo-cortical circuit [150]. The difficulties of cerebellar patients to adapt to changes in the damping of the joints also argue for such a predictive role [151].…”

Section: Mario Manto Hiroshi Mitomamentioning

confidence: 99%

Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications

et al. 2018

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Time perception is an essential element of conscious and subconscious experience, coordinating our perception and interaction with the surrounding environment. In recent years, major technological advances in the field of neuroscience have helped foster new insights into the processing of temporal information, including extending our knowledge of the role of the cerebellum as one of the key nodes in the brain for this function. This consensus paper provides a state-of-the-art picture from the experts in the field of the cerebellar research on a variety of crucial issues related to temporal processing, drawing on recent anatomical, neurophysiological, behavioral, and clinical research.The cerebellar granular layer appears especially well-suited for timing operations required to confer millisecond precision for cerebellar computations. This may be most evident in the manner the cerebellum controls the duration of the timing of agonist-antagonist EMG bursts associated with fast goal-directed voluntary movements. In concert with adaptive processes, interactions within the cerebellar cortex are sufficient to support sub-second timing. However, supra-second timing seems to require cortical and basal ganglia networks, perhaps operating in concert with Cerebellum.Additionally, sensory information such as an unexpected stimulus can be forwarded to the cerebellum via the climbing fiber system, providing a temporally constrained mechanism to adjust on-going behavior and modify future processing. Patients with cerebellar disorders exhibit impairments on a range of tasks that require precise timing, and recent evidence suggest that timing problems observed in other neurological conditions such as Parkinson's disease, essential tremor, and dystonia, may reflect disrupted interactions between the basal ganglia and cerebellum.The complex concepts emerging from this consensus paper should provide a foundation for further discussion, helping identify basic research questions required to understand how the brain represents and utilizes time, as well as delineating ways in which this knowledge can help improve the lives of those with neurological conditions that disrupt this most elemental sense. The panel of experts agrees that timing control in the brain is a complex concept in whom cerebellar circuitry is deeply involved. The concept of a timing machine has now expanded to clinical disorders. The Cerebellum Represents Isolated Temporal Intervals Across Task Domains Assaf Breska and Richard B. IvryIt is widely accepted that the cerebellum contributes, in some manner, to temporal processing, but the functional domain and computational mechanisms remain the subject of considerable debate. An early hypothesis was that the cerebellum served as a centralized, dedicated timing system [6,7].

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“…EMG studies have shown delayed onset latencies of antagonist activities [68], abnormal rates of rise of agonist/antagonist EMG activities [100] and impaired adaptation to mechanical conditions such as increased inertia or damping [107]. The agonist EMG activity is characterized by smaller magnitudes (smaller torques to generate a launching force) and prolonged duration [68, 100].…”

Section: Cerebellar Dysmetria (Florian Bodranghien and Mario Manto)mentioning

confidence: 99%

Consensus Paper: Revisiting the Symptoms and Signs of Cerebellar Syndrome

Bodranghien¹,

et al. 2015

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The cerebellum is involved in sensorimotor operations, cognitive tasks and affective processes. Here, we revisit the concept of the cerebellar syndrome in the light of recent advances in our understanding of cerebellar operations. The key symptoms and signs of cerebellar dysfunction, often grouped under the generic term of ataxia, are discussed. Vertigo, dizziness, and imbalance are associated with lesions of the vestibulo-cerebellar, vestibulo-spinal, or cerebellar ocular motor systems. The cerebellum plays a major role in the online to long-term control of eye movements (control of calibration, reduction of eye instability, maintenance of ocular alignment). Ocular instability, nystagmus, saccadic intrusions, impaired smooth pursuit, impaired vestibulo-ocular reflex (VOR), and ocular misalignment are at the core of oculomotor cerebellar deficits. As a motor speech disorder, ataxic dysarthria is highly suggestive of cerebellar pathology. Regarding motor control of limbs, hypotonia, a- or dysdiadochokinesia, dysmetria, grasping deficits and various tremor phenomenologies are observed in cerebellar disorders to varying degrees. There is clear evidence that the cerebellum participates in force perception and proprioceptive sense during active movements. Gait is staggering with a wide base, and tandem gait is very often impaired in cerebellar disorders. In terms of cognitive and affective operations, impairments are found in executive functions, visual-spatial processing, linguistic function, and affective regulation (Schmahmann’s syndrome). Nonmotor linguistic deficits including disruption of articulatory and graphomotor planning, language dynamics, verbal fluency, phonological, and semantic word retrieval, expressive and receptive syntax, and various aspects of reading and writing may be impaired after cerebellar damage. The cerebellum is organized into (a) a primary sensorimotor region in the anterior lobe and adjacent part of lobule VI, (b) a second sensorimotor region in lobule VIII, and (c) cognitive and limbic regions located in the posterior lobe (lobule VI, lobule VIIA which includes crus I and crus II, and lobule VIIB). The limbic cerebellum is mainly represented in the posterior vermis. The cortico-ponto-cerebellar and cerebello-thalamocortical loops establish close functional connections between the cerebellum and the supratentorial motor, paralimbic and association cortices, and cerebellar symptoms are associated with a disruption of these loops.

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A New Myohaptic Instrument to Assess Wrist Motion Dynamically

Cited by 11 publications

References 30 publications

Consensus Paper: Roles of the Cerebellum in Motor Control—The Diversity of Ideas on Cerebellar Involvement in Movement

Consensus Paper: Roles of the Cerebellum in Motor Control—The Diversity of Ideas on Cerebellar Involvement in Movement

Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications

Consensus Paper: Revisiting the Symptoms and Signs of Cerebellar Syndrome

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