A New mouthwash for Chemotherapy Induced Stomatitis

Abstract

Background: Stomatitis is a disturbing side-effect of chemotherapy that disturbs patients and causes difficulties in patient’s drinking, eating and talking, and may results in infection and bleeding. Objectives: This study aimed to investigate the effect of Yarrow distillate in the treatment of chemotherapy-induced stomatitis. Patients and Methods: This randomized controlled trial study was conducted during 2013. The study population consisted of all cancer patients with chemotherapy-induced oral stomatitis referred to Shahid Beheshti Medical Center, Kashan, Iran. The data collection instrument had two-part; a demographic part and another part recording the severity of the stomatitis at the first, seventh, and 14th days of the intervention based on a WHO criteria checklist in 2005. In this study, 56 patients diagnosed with cancer were randomly assigned into control and experimental groups in similar blocks according to their stomatitis severity. The experimental group gargled 15 mL of a routine solution mixed with Yarrow distillate 4 times a day for 14 days while the control group gargled 15 mL of routine solution. The severity of stomatitis was assessed at the beginning of the intervention, and then after 7 and 14 days of the study. Data were analyzed using chi-square and Fisher exact test, Mann-Whitney U, Kruskal-Wallis, and Friedman tests using SPSS 11.5 software. Results: At first, the median score of stomatitis in the experimental group was 2.50 that significantly reduced to 1 and 0 in days 7 and 14 of the intervention, respectively ( P value < 0.001). However, in the control group, the median score of stomatitis was 2.50, which significantly increased to 3 in days 7 and 14 ( P value < 0.001). Conclusions: Yarrow distillate-contained solution reduced stomatitis severity more than the routine solution. Therefore, we suggest using it in patients with chemotherapy-induced stomatitis.

Herbs in Oral Mucositis

“…This herb is a commonly used agent in ancient medicine and contains chamazulene, cineol, and borneol, which can provide antibacterial, anti-inflammatory and anti-spasmodic properties. Miranzadeh S et al, in 2014 showed that Yarrow distillate contained solution has a decreasing effect on the intensity of oral mucositis compared with the control group. The result may propose Yarrow distillate as a useful herb in oral mocositis treatment [50].…”

Systematic review of natural and miscellaneous agents, for the management of oral mucositis in cancer patients and clinical practice guidelines — part 2: honey, herbal compounds, saliva stimulants, probiotics, and miscellaneous agents

“…A variety of herbal remedies were reported for the prevention or treatment of OM since the previous guidelines update [ Table 5]. This includes pycnogenol [61], olive leaf [62], Kangfuxin [63], Camelia Sinensis leaf and and Palmitoyil hydrolyzed wheat protein (Baxidil Onco) [64], clove-based herbal compound [65], Yashtimadhu ghrita (processed ghee)/Licorice [66], Calendula [67], and Yarrow plant (also called Achillea millefolium) [68]. Each intervention had a single RCT.…”

Beneficial Biological Activities of Cinnamomum osmophloeum and Its Potential Use in the Alleviation of Oral Mucositis: A Systematic Review

“…), honey, Traumeel S, water grass decoction, and Weleda Ratanhia, also showed similar effects on the alleviation of OM via anti-inflammation activities [17,[63][64][65][66][67][68][69][70][71][72]. The bioactive properties of the yarrow plant (Achillea mileofolium), honey, Callendula officinalis flowers, Hipophae rhamnoides L. plant, Chamomile, and Aloe vera were associated with antioxidant, anti-inflammatory, antibacterial, and wound healing effects of oral mucositis therapy (Table 4) [64][65][66][72][73][74][75][76][77]. Similar to the advantages of the medical-biological activities of these herbal agents, C. osmophloeum would provide an identical mechanism for relieving oral mucositis.…”