A new mixed inhibitor of adenosine deaminase produced by endophytic Cochliobolus sp. from medicinal plant seeds

Glycosides and flavonoids from the extract of Pueraria thomsonii Benth leaf alleviate type 2 diabetes in high-fat diet plus streptozotocin-induced mice by modulating the gut microbiota

“…The chemical structures were identified by comparing NMR data with those found in the literature (ESI†). They are diglucosyldirhamnoside ( PL-1 ), 23 rutin ( PL-2 ), 24 melibiose ( PL-3 ), 25 neryl-1- O -β-D-glucopyranosyl-(1 → 2)- O -[α- l -arabinopyranosyl-(1 → 6)]- O -β- d -glucopyranoside ( PL-4 ), 26 β- d -apiofuranosyl-(1 → 6)-β- d -(1- O -methyl)-glucopyranoside ( PL-5 ), 27 N -vanillyl-nonanamide-β-lactoside ( PL-6 ), 28 palmatoside B ( PL-7 ), 29 trans -3-hydroxy-1,8-cineole 3- O -β- d -glucopyranoside ( PL-8 ), 30 robinin ( PL-9 ), 31 phenyl-β- d -glucopyranoside ( PL-10 ), 32 euodionoside D ( PL-11 ), 33 germacradiene-6- O -(6′- O -acetyl)-β- d -glucoside ( PL-12 ), 34 ethyl α-L-rhamnopyranosyl-(1 → 6)-β- d -glucoside ( PL-13 ), 35 olaximbriside D ( PL-14 ), 36 puerarin ( PL-15 ), 37 daidzin ( PL-16 ), 38 daidzein ( PL-17 ), 39 viburtinoside IV ( PL-18 ), 40 (3 R ,9 R )-5-megastigmen-3, 9, 11-triol 9- O -β- d -glucopyranoside ( PL-19 ), 41 8-debenzoylpaeoniflorin ( PL-20 ), 42 raffinose ( PL-21 ), 43 6-hydroxyhexyl β- d -glucopyranoside ( PL-22 ), 44 β- d -fructopyranosyl-(2 → 6)-α- d -glucopyranosyl-(1 ↔ 2)-β- d -fructofuranoside ( PL-23 ), 45 quercetin ( PL-24 ), 46 quercitrin ( PL-25 ), 47 isoquercitrin ( PL-26 ), 48 esculin ( PL-27 ), 49 kaempferol ( PL-28 ), 50 and arbutin ( PL-29 ). 51 The flavonoids and their derivatives were PL- 2 , 9 , 15–17 , 24–26 , and 28 .…”

“…The chemical structures were identified by comparing NMR data with those found in the literature (ESI †). They are diglucosyldirhamnoside (PL-1), 23 rutin (PL-2), 24 melibiose (PL-3), 25 27 N-vanillyl-nonanamide-β-lactoside (PL-6), 28 palmatoside B (PL-7), 29 trans-3-hydroxy-1,8-cineole 3-O-β-Dglucopyranoside (PL-8), 30 robinin (PL-9), 31 phenyl-β-D-glucopyranoside (PL-10), 32 euodionoside D (PL-11), 33 35 olaximbriside D (PL-14), 36 puerarin (PL-15), 37 daidzin (PL-16), 38 daidzein (PL-17), 39 viburtinoside IV (PL-18), 40 (3R,9R)-5-megastigmen-3, 9, 11-triol 9-Oβ-D-glucopyranoside (PL-19), 41 8-debenzoylpaeoniflorin (PL-20), 42 raffinose (PL-21), 43 6-hydroxyhexyl β-D-glucopyranoside (PL-22), 44 45 quercetin (PL-24), 46 quercitrin (PL-25), 47 isoquercitrin (PL-26), 48 esculin (PL-27), 49 kaempferol (PL-28), 50 and arbutin (PL-29). 51 The flavonoids and their derivatives were PL-2, 9, 15-17, 24-26, and 28.…”

Secondary Metabolites from the Coral-Derived Fungus Aspergillus austwickii SCSIO41227 with Pancreatic Lipase and Neuraminidase Inhibitory Activities

“…The 13 C NMR data of 4 showed the presence of eight carbons, including a carbonyl group (δ C 173.5) and one oxymethylene group (δ C , 59.5). The diagnostic NMR data (Table 2, Figures S21-S24) exhibited several similarities to compound 8 [12]. The only discernible difference was the identification of an ethyl group located at C-6, which was confirmed by the corresponding NMR signals (δ H 2.14 and 1.16; δ C 21.0 and 11.0), as well as key HMBC correlations from H-7 to C-6 and C-8 (Figure 2).…”

Phytochemical analysis and anti-infective potential of fungal endophytes isolated from Nigella sativa seeds

“…SA2, and Aspergillus sp. SA3 results in annotation of 26 compounds (1-7), (8)(9)(10)(11)(12)(13)(14)(15)(16)(17) and (18)(19)(20)(21)(22)(23)(24)(25)(26) respectively, as shown in Table 1; Fig. 4.…”

“…Natural compounds from endophytic fungi are potential candidates for new antibiotics against pathogenic bacteria [11]. Therefore, in recent years, more attention has been given to the endophytic fungi of medicinal plants, which represent a rich source of new and useful natural compounds of interest to the pharmaceutical and agricultural industries and a potential source for the discovery of novel microorganisms [12][13][14]. Nigella Sativa seeds (Ranunculaceae), commonly known as black seed or black cumin, traditionally used for treatments of various illness affected lungs, kidney, GIT, circulatory and immune systems [15,16].…”