A new minor diketopiperazine from the sponge-derived fungus <i>Simplicillium</i> sp. YZ-11

Yan, Bing-Fei; Fang, Shu; Li, Wenzuo; Liu, Su-Jing; Wang, Jianhua; Xia, Chuanhai

doi:10.1080/14786419.2015.1027890

Cited by 22 publications

(10 citation statements)

References 13 publications

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“…Simplicillium species have a wide distribution and are considered as mammal and plant-parasitic, symbiotic, entomopathogenic, fungicolous and nematophagous fungi, as they have a broad spectrum of hosts and substrates, such as insects, plants, rusts, nematodes, human nails, canine tissues and mushrooms, Chroococcus sp., soil, freshwater, marine and terrene environments (Zare and Gams 2001; Guo et al 2012; Liu and Cai 2012; Dong et al 2014; Liang et al 2016; Sun et al 2019). Several studies have been shown that Simplicillium species have a high ecological and economical value for biocontrol and bioactive compounds (Takata et al 2013; Yan et al 2015; Hyde et al 2019). For example, Simplicillium lanosoniveum can be a phytopathogen, causing brown spots and lesions on flowers (Chen et al 2008) or a mycoparasite on soybean rust (Ward et al 2012; Gauthier et al 2014) or a pathogen on aphids and other phytopathogens (Chen et al 2017) or an anti- Trichomonas vaginalis agent (Scopel et al 2013).…”

Section: Introductionmentioning

confidence: 99%

The genus Simplicillium

Wei¹,

Wanasinghe²,

Hyde³

et al. 2019

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Simplicillium species have a wide host range and an extensive distribution. Some species are associated with rusts, as well as other plant pathogenic fungi and play an important role in biological control. In this study, two specimens of Simplicillium were collected from Chiang Mai Province, Thailand. Simplicillium formicae sp. nov. was isolated from an infected ant and S. lanosoniveum from Ophiocordyceps unilateralis which is a new host record. Species were initially identified using ITS gene sequences and confirmed using morphology coupled with phylogenetic analyses of a combined nrLSU, nrSSU, TEF and RPB1 dataset. Simplicillium formicae differs from other species in the genus by the presence of flask-shaped synnemata and phialides with intercalary nodes. Simplicillium lanosoniveum resembles other collections of the species by its completely solitary, tapering phialides and globose to ellipsoidal conidia which adhere in a slimly head. A key to species of Simplicillium is also provided.

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Section: Introductionmentioning

confidence: 99%

The genus Simplicillium

Wei¹,

Wanasinghe²,

Hyde³

et al. 2019

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“…Other substrata were found later, such as limstone and wood (Liu and Cai 2012; Zhang et al 2017). Many bioactive compounds were discovered in Simplicillium , such as alkaloids (Fukuda et al 2014), peptides (Liang et al 2016; 2017; Dai et al 2018), diketopiperazine (Yan et al 2015), xylanases (Roy et al 2013), anthraquinones (Huang et al 2015), antibiotics (Takata et al 2013; Dong et al 2018), and especially Simpotentin, which is a new potentiator of amphotericin B activity against Candida albicans (C. P. Robin) Berkhout and has showed great potential applications in medicine (Uchida et al 2019). Furthermore, the antimicrobial activities and entomopathogenicity has meant that Simplicillium has potential applications in biocontrol (Ward et al 2012; Zhao et al 2013; Le Dang et al 2014; Lim et al 2014; Chen et al 2017; Skaptsov et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Three novel insect-associated species of Simplicillium (Cordycipitaceae, Hypocreales) from Southwest China

Chen¹,

Liu²,

Han³

et al. 2019

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In this paper, we introduce three new species of Simplicillium, viz. S. cicadellidae, S. formicidae and S. lepidopterorum, which were isolated from an infected leafhopper, ant and carpenterworm, respectively. Morphological comparisons and phylogenetic analyses based on multigene datasets (LSU+RPB1+RPB2+TEF and ITS+LSU) support the establishment of the three new species. Simplicillium cicadellidae was distinguished from other species in morphological characteristics by having smaller phialides and ellipsoidal conidia, and lacking octahedral crystals. The reverse of colonies were yellowish (#FFBF00), especially in the middle, and radially sulcate. Simplicillium formicidae was morphologically distinguished from other by having longer phialides and filiform to fusoid conidia, and by lacking octahedral crystals. Simplicillium lepidopterorum was morphologically distinguished from other species by having smaller, ellipsoidal to fusiform conidia, and by lacking octahedral crystals. The reverse of the colony was pale white. The three new species are likely to be nourished by plant to animal (especially insect) nutrients based on the evolutionary pattern of the Hypocreales, and they are described herein as being clearly distinct from other species in Simplicillium.

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“…Cyclo-(2-hydroxy-Pro-Gly) (152), a novel minor DKP, was obtained from the fungus Simplicillium sp. YZ-11, which was collected from an intertidal sponge Hymeniacidon perleve from Dalian, Liaoning Province, China [77] One novel DKP dimer (155) possessing the same planar structure and different stereochemistry with an unnamed and ambiguous compound was isolated from the fungus Aspergillus violaceofuscus, which was collected from sponge Reniochalina sp. from Xisha Islands in the South China Sea.…”

Section: Fungi From Sponge Originmentioning

confidence: 99%

Section: Chemical Structures Of Diketopiperazines From Marine Organismsmentioning

confidence: 99%

Structures and Biological Activities of Diketopiperazines from Marine Organisms: A Review

et al. 2021

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Diketopiperazines are potential structures with extensive biological functions, which have attracted much attention of natural product researchers for a long time. These compounds possess a stable six-membered ring, which is an important pharmacophore. The marine organisms have especially been proven to be a wide source for discovering diketopiperazine derivatives. In recent years, more and more interesting bioactive diketopiperazines had been found from various marine habitats. This review article is focused on the new 2,5-diketopiperazines derived from marine organisms (sponges and microorganisms) reported from the secondary half-year of 2014 to the first half of the year of 2021. We will comment their chemical structures, biological activities and sources. The objective is to assess the merit of these compounds for further study in the field of drug discovery.

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A new minor diketopiperazine from the sponge-derived fungus Simplicillium sp. YZ-11

Cited by 22 publications

References 13 publications

The genus Simplicillium

The genus Simplicillium

Three novel insect-associated species of Simplicillium (Cordycipitaceae, Hypocreales) from Southwest China

Structures and Biological Activities of Diketopiperazines from Marine Organisms: A Review

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