“…Importantly, this method tolerates the presence of amines, ketones, esters and other functional groups ( Table 1, entries 10-12 and 15), and the reaction with sterically hindered aldehydes gave 19 and 20 with 79-85 % yield and 84-87 % ee (Table 1, entries 13 and 14). Finally, the copper-catalyzed aldol reaction between the 2-naphthylsubstituted geminal diol and various aldehydes, including enolizable substrates such as cyclohexanecarboxaldehyde and 3-phenylpropionaldehyde, gave 24-28 in up to 94 % yield and 88 % ee (Table 1, entries [18][19][20][21][22].…”