A new method of scoring coronary angiograms to reflect extent of coronary atherosclerosis and improve correlation with major risk factors

Sullivan, David; Marwick, Thomas H.; Freedman, Ben

doi:10.1016/s0002-8703(05)80173-5

Cited by 256 publications

(188 citation statements)

References 33 publications

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“…31,32 In our patients, inflammatory markers were clearly increased in atherosclerotic disease of the coronary and peripheral arteries, even in the absence of unstable angina pectoris (present in only 5% of patients) or myocardial infarction. In previous cross-sectional studies, 4,41 an elevated level of CRP was found to be indicative of "active" CAD manifesting as unstable angina pectoris, plaque rupture, or acute myocardial infarction, whereas in prospective studies, even slight differences in the median CRP levels were found to be predictive of myocardial infarction, stroke, and PAD in men.…”

Section: Discussionmentioning

confidence: 53%

“…The grade and type of coronary atherosclerosis were scored from the angiographic data retrieved in digital format from CD-ROM by counting the number of affected vessels and by calculating a stenosis score 31,32 as follows. The coronary artery system as displayed in the angiographic movie was first divided into 8 segments: left main stem, left anterior descending artery, diagonal branch, first septal perforator, left circumflex artery, marginal or posterolateral branch, right coronary artery, and main posterior descending branch.…”

Section: Angiographic Scoresmentioning

confidence: 99%

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Systemic Inflammatory Parameters in Patients With Atherosclerosis of the Coronary and Peripheral Arteries

Erren

Reinecke

Junker

et al. 1999

ATVB

275

149

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Section: Discussionmentioning

confidence: 53%

Section: Angiographic Scoresmentioning

confidence: 99%

Systemic Inflammatory Parameters in Patients With Atherosclerosis of the Coronary and Peripheral Arteries

Erren

Reinecke

Junker

et al. 1999

ATVB

275

149

View full text Add to dashboard Cite

show abstract

“…The severity of coronary artery stenosis was assessed using the Gensini score. 15) The clinical parameters are expressed as the mean ± SE. All statistical analyses were performed using the JMP for Windows software (version 4.0; SAS Institute, Cary, NC).…”

Section: Methodsmentioning

confidence: 99%

Reduced Adiponectin Level Is Associated With Severity of Coronary Artery Disease

et al. 2007

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SUMMARYAdipocyte-derived adiponectin has an antiatherosclerotic effect that acts independently of its antidiabetic effect. Plasma adiponectin levels are generally low in subjects with coronary artery disease. In this study, the relationship between the plasma adiponectin level and the severity of coronary artery disease, as assessed using the Gensini score, an index for the severity of coronary artery stenosis, was investigated. The subjects of the study were 104 patients (72 men and 32 women; BMI, 23.5 ± 3.3 kg/m 2 ; age, 63.6 ± 10.1 years) admitted to Tokyo University Hospital for coronary angiography. Plasma adiponectin levels were inversely correlated with the insulin resistance index HOMA-IR (P = 0.0127). The plasma adiponectin level was significantly associated with the Gensini score (P = 0.0332). After adjustment for conventional risk factors for cardiovascular diseases, the plasma adiponectin level tended to be inversely correlated with the Gensini score (P = 0.087). The measurement of plasma adiponectin levels may be useful for predicting the severity of coronary artery stenosis. (Int Heart J 2007; 48: 149-153)

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“…For this study, we defined significant CAD as at least 1 50% or greater diameter stenosis in at least 1 coronary vessel or prior percutaneous or surgical coronary revascularization. The extent of CAD was defined as (1) 1-, 2-, or 3-vessel disease and (2) addition of a modified stenosis score system (minimum score was 0; maximum score was 27), 15 with 0, 1, 2, and 3 points, respectively, for Ͻ50%, 50% to 70%, 71% to 89%, and Ն90% diameter stenosis in 1 to 3 segments of the 3 main coronary arteries (a total of 9 segments). The absence of CAD was defined as completely smooth epicardial coronary arteries without any narrowings visible on coronary angiogram.…”

Section: Coronary Angiographymentioning

confidence: 99%

Arterial Stiffness, Wave Reflections, and the Risk of Coronary Artery Disease

Weber

Auer²,

O’Rourke³

et al. 2004

Circulation

985

673

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Background-Increased arterial stiffness, determined invasively, has been shown to predict a higher risk of coronary atherosclerosis. However, invasive techniques are of limited value for screening and risk stratification in larger patient groups. Methods and Results-We prospectively enrolled 465 consecutive, symptomatic men undergoing coronary angiography for the assessment of suspected coronary artery disease. Arterial stiffness and wave reflections were quantified noninvasively using applanation tonometry of the radial artery with a validated transfer function to generate the corresponding ascending aortic pressure waveform. Augmented pressure (AP) was defined as the difference between the second and the first systolic peak, and augmentation index (AIx) was AP expressed as a percentage of the pulse pressure.In univariate analysis, a higher AIx was associated with an increased risk for coronary artery disease (OR, 4.06 for the difference between the first and the fourth quartile [1.72 to 9.57; PϽ0.01]). In multivariate analysis, after controlling for age, height, presence of hypertension, HDL cholesterol, and medications, the association with coronary artery disease risk remained significant (OR, 6.91; PϽ0.05). The results were exclusively driven by an increase in risk with premature vessel stiffening in the younger patient group (up to 60 years of age), with an unadjusted OR between AIx quartiles I and IV of 8.25 (PϽ0.01) and a multiple-adjusted OR between these quartiles of 16.81 (PϽ0.05). Conclusions-AIx and AP, noninvasively determined manifestations of arterial stiffening and increased wave reflections, are strong, independent risk markers for premature coronary artery disease.

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A new method of scoring coronary angiograms to reflect extent of coronary atherosclerosis and improve correlation with major risk factors

Cited by 256 publications

References 33 publications

Systemic Inflammatory Parameters in Patients With Atherosclerosis of the Coronary and Peripheral Arteries

Systemic Inflammatory Parameters in Patients With Atherosclerosis of the Coronary and Peripheral Arteries

Reduced Adiponectin Level Is Associated With Severity of Coronary Artery Disease

Arterial Stiffness, Wave Reflections, and the Risk of Coronary Artery Disease

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