A New Method of Mueller-Matrix Diagnostics and Differentiation of Early Oncological Changes of the Skin Derma

Abstract

The paper deals with investigation of the processes of laser radiation transformation by biological crystals networks using the singular optics techniques. The results obtained showed a distinct correlation between the points of “characteristic” values of coordinate distributions of Mueller matrix () elements and polarization singularities (L- and C-points) of laser transformation of biological crystals networks with the following possibility of Mueller-matrix selection of polarization singularity. The technique of Mueller-matrix diagnostics of pathological changes of skin derma is proposed.

Fluorescent Mueller-matrix polarimetry of biological tissues in differentiation of benign and malignant tumors

“…The detailed description of the optical scheme and basic parts of experimental setup was presented in a series of articles [21][22][23][24][25][26][27][28]. In this research, for autofluorescence excitation we used a diode laser with the wavelength λ = 405 μm and power W = 50 μW.…”

“…4), which characterizes the processes of transformation of linearly polarized fluorescent radiation into a circular one. As it is well known [21][22][23][24][25][26][27][28][29][30][31], orientationally (ρ)-phase (δ, θ) structure of this matrix depends on physiological (pathological) state of biological tissue. More disordered by directions (    ) birefringent (Δn ≈ const) fibrillar network is typical for malignant states.…”

“…In this work, we have limited ourselves by considering the spectral-selective case -luminescence of optically active porphyrins of biological tissue in red (λ f = 0.63…0.65 μm) spectral range [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. Excitation of autofluorescence was realized using a blue solid-state laser with the wavelength λ = 0.405 μm that coincides with the porphyrin absorption peak.…”

Azimuthally invariant laser polarimetry of polycrystalline smears of biological liquids

“…To describe interactions of polarized light with these complex systems, the most general approaches based on Muellermatrix formalism are required. Nowadays in biological and medical investigations, many practical techniques based on measurement and analysis of Mueller matrices of investigated samples are used [1][2][3][4][5][6][7][8][9][10][11][12]. In recent 10-15 years, a separate approach -laser polarimetry [13] -was formed in matrix optics.…”

Laser polarization-variable autofluorescence of the network of optically anisotropic biological tissues: Diagnostics and differentiation of early stages of cancer ofcervix uteri

“…was realized. [12][13][14][15][16][17] The optical techniques of investigation of biological tissues called \optical biopsy" are widespread in modern medical diagnostics. The analysis of luminescence of such objects occupies a special place among the optical biopsy techniques.…”