A new method of intralesional bleomycin therapy in the treatment of recalcitrant warts

Munn, S.E.; Higgins, Elisabeth M.; Marshall, M; Clement, Michele

doi:10.1046/j.1365-2133.1996.d01-1104.x

Cited by 78 publications

(69 citation statements)

References 12 publications

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“…Thus, their average duration approaches the mean duration of spontaneous cure. The clearance rate of 87.88% achieved in the present study is similar to that of previous reports using bleomycin [3,4,6,7,8,9,10]. While the pharmacological mechanism of pingyangmycin for wart treatment remains to be revealed, we assume that it has clinical effects similar to bleomycin as pingyangmycin is a member of the bleomycin reagent family [11].…”

Section: Discussionsupporting

confidence: 79%

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Intralesional Pingyangmycin Treatment for Resistant Plantar Warts

Yang¹,

Qin²,

Cheng³

et al. 2009

Dermatology

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Background: The diagnosis of viral warts is often straightforward, but their treatment is difficult and always takes a long time. Nowadays warts are usually treated with conventional methods including topical keratolytic agents, cryotherapy, electrosurgery and laser surgery. However, such treatments cause different complications, and the warts become recalcitrant. Objective: To investigate the effect of intralesional pingyangmycin injection for resistant plantar warts. Methods: From June 2006 to September 2008, we treated 66 patients with plantar warts by intralesional pingyangmycin injection after informed consent. Results: The lesions of 58 patients cleared (87.88%) after up to 4 treatments. The remaining 8 patients (12.12%) achieved partial clearance. No serious side effects were observed. Conclusion: Intralesional injection of pingyangmycin might be an effective, safe and generally well-tolerated treatment for plantar warts.

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Section: Discussionsupporting

confidence: 79%

“…Previous studies have demonstrated that bleomycin is effective in over two thirds of wart cases [3,4]. The exact mechanism of bleomycin is yet unclear.…”

Section: Introductionmentioning

confidence: 99%

Intralesional Pingyangmycin Treatment for Resistant Plantar Warts

Yang¹,

Qin²,

Cheng³

et al. 2009

Dermatology

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“…This has resulted in a 92% clearance rate. 182 Others have used modified tattooing devices with some success. 172 Five randomized, controlled trials have evaluated the effectiveness of bleomycin; 102 however, it is difficult to compare the trials.…”

Section: Antimitotic Therapymentioning

confidence: 99%

An Armamentarium of Wart Treatments

Lipke¹

2006

Clinical Medicine & Research

284

295

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Patients and clinicians experience the frustration of cutaneous viral warts caused by infection with the human papilloma virus (HPV).Warts appear in various forms on different sites of the body and include common warts (verruca vulgaris), plane or flat warts, myrmecia, plantar warts, coalesced mosaic warts, filiform warts, periungual warts, anogenital warts (venereal or condyloma acuminata), oral warts and respiratory papillomas. Cervical infection with HPV is now known to cause cervical cancer if untreated. A review of the medical literature reveals a huge armamentarium of wart monotherapies and combination therapies. Official evidence-based guidelines exist for the treatment of warts, but very few of the reported treatments have been tested by rigorous blinded, randomized controlled trials.Therefore, official recommendations do not often include treatments with reportedly high success rates, but they should not be ignored when considering treatment options. It is the purpose of this review to provide a comprehensive overview of the wart treatment literature to expand awareness of the options available to practitioners faced with patients presenting with problematic warts. Warts of the genital tract carry a much more ominous and pernicious threat for women in particular. It has been estimated that up to 70% of sexually active women become infected during their lifetime with human papillomavirus (HPV), the infective agent that causes warts. 3-5 A causal role for HPV infections in cervical cancer has been documented beyond reasonable doubt. HPV DNA is present in virtually all cervical cancer cases worldwide, with it being detected in 99.7% of an international series of cervical cancers by genetic amplification techniques and in 100% of cases as confirmed by histological review. 6,7 Cervical cancer is the most frequent common cancer in developing countries and the second most common cancer in women worldwide. 3 The association between HPV infection and cervical cancer is so strong that HPV is now considered the first positive cause of any human cancer ever identified. 3This raises the level of concerns over HPV prevention, screening and treatment from that of a nuisance condition to that of a major public health concern. Attention is beginning to focus on the viral factors that determine persistence and neoplastic progression to cancer and the possible role of HPV in other nongenital cancers (e.g., skin, upper aerodigestive tract). [8][9][10][11][12][13][14][15][16][17] Patients with warts seek advice from general practitioners, pharmacists, naturopaths, allied health professionals, family or friends, dermatologists, gynecologists, obstetricians and pediatricians for treatment and may present with recalcitrant warts that have been previously treated with anything from folk remedies to hypnosis to over-the-counter medications to more aggressive clinic-based treatments. Unfortunately, even with years of medical literature on this subject, high-quality, level I evidence for the efficacy of almost all treatments is no...

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“…This obvious response to treatment makes it difficult to conduct double-blinded trials, and many studies have been open studies or have used bleomycin in comparison with saline injection or cryotherapy. Open studies have suggested clearance rates of approximately 20-90% of treated warts with one or more treatments, 101,102 with most reporting a patient response rate of approximately 65-85%. 101,103 Several trials of intralesional bleomycin have used saline as a placebo.…”

mentioning

confidence: 99%