A new method for the preparation of gelatin nanoparticles: Encapsulation and drug release characteristics

Abstract

A new and simple method was developed to produce gelatin nanoparticles of $ 30-40 nm for use as carriers for drug release applications. The nanoparticles were uniform in size and well dispersed. An anticancer drug, 5-fluorouracil, was encapsulated with an efficiency as high as 85%. The nanoparticles showed sustained release of 5-fluorouracil, and release rates varied with amount of crosslinking in the nanoparticles.

Design and Characterization of Surface‐Crosslinked Gelatin Nanoparticles for the Delivery of Hydrophilic Macromolecular Drugs

“…Briefly, the solvent phase (aqueous solution of gelatin) is added dropwise to the anti‐solvent (acetone) containing stabilizer . Due to diffusion of the solvent phase into the anti‐solvent phase, a strong interfacial turbulence is produced which leads to precipitation of gelatin at the interface in the form of GNPs . Subsequently, the crosslinker DIC was added to the nanosuspension followed by stirring for 24 h to favor crosslink formation on GNPs.…”

“…[36,43] Due to diffusion of the solvent phase into the anti-solvent phase, a strong interfacial turbulence is produced which leads to precipitation of gelatin at the interface in the form of GNPs. [42,44,45] Subsequently, the crosslinker DIC was added to the nanosuspension followed by stirring for 24 h to favor crosslink formation on GNPs. The preparation procedure is shown schematically in…”

Encapsulation of Piper aduncum and Piper hispidinervum essential oils in gelatin nanoparticles: a possible sustainable control tool of Aedes aegypti, Tetranychus urticae and Cerataphis lataniae

“…The controlled release of EOs encapsulated in biopolymeric nanoparticles is of special interest owing to the prolonged duration of action and the biological degradation of wall materials . For this reason, gelatin nanoparticles have been used successfully as a carrier for drugs and bioactive molecules . Interest in using gelatin as a biodegradable material is based on the fact that it is Food and Drug Administration (FDA) approved, biodegradable, non‐toxic and easy to crosslink and to modify chemically…”

Delivery Systems Made of Natural‐Origin Polymers for Tissue Engineering and Regenerative Medicine Applications

“…Gellatin nanoparticles were also used to incorporate and to sustain release of the anticancer drug 5-fluorouracil [64]. Starch-based porous materials also demonstrated the ability for the controlled release of meclofenamic sodium salt, a nonsteroidal anti-inflammatory drug [65].…”