A New Method for the Conversion of Aldoximes Into Nitriles With Zeolites

Postsynthesis‐Treated Iron‐Based Metal–Organic Frameworks as Selective Catalysts for the Sustainable Synthesis of Nitriles

“…[23] Acid zeolites( HY,H -MOR, H-Beta, H-ZSM-5), Montmorillonite K-10 clay,a nd g-alumina have also been reported for the dehydration of benzaldehyde oxime and 4-methoxybenzaldehydeo xime in the vapor phase in af ixed-bed reactor, which gave moderate yields of the corresponding nitriles. However,i nc lear contrastw ith the wide variety of homogeneous catalysts used for this transformation, the use of heterogeneousc atalysts for the dehydration of aldoximes to nitriles is limited.…”

“…However,ahigh temperature (250 8C) and an additive, such as benzene, were required. [23] Acid zeolites( HY,H -MOR, H-Beta, H-ZSM-5), Montmorillonite K-10 clay,a nd g-alumina have also been reported for the dehydration of benzaldehyde oxime and 4-methoxybenzaldehydeo xime in the vapor phase in af ixed-bed reactor, which gave moderate yields of the corresponding nitriles. [24] The dehydration of aldoximes has been performed in the liquid phase using different heterogeneous catalysts that contain Lewis acid or basic sites such as Montmorillonite KSF, [25] Envirocat-EPZG, [26] KF/alumina, [27] [RuCl 2 (p-cymene)] 2 complex supported on carbon, [28] and tungsten-tin mixed hydroxide (W-Sn-hydroxide).…”

P(RNCH2CH2)3N: A versatile and efficient catalyst for the conversion of aldoximes to nitriles

“…Although a wide variety of reagents have been reported for this transformation, many of these methods present disadvantages. For example, dehydration with montmorillonite KSF [2], zeolites [3], and envirocat EPZG [4] requires high reaction temperatures or relatively long reaction times. Reagents such as triethylamine/sulfur dioxide [5] and sulfuryl chloride [6] allow rapid and mild dehydration of aldoximes, but the preparation of these reagents is inconvenient, requiring a low temperature (‫87מ‬ЊC).…”

One-Pot Conversion of Aldoximes Into Nitriles via Aldoxime Tosylates Under Microwave Irradiation

“…3 Direct conversion of aldehydes to nitriles has been also reported. 4 Nitriles can be synthesized from the dehydration of the corresponding oximes using a variety of reagents such as trimethyl amine/sulfur dioxide, 5 zeolite, 6 sulphoryl chloride fluoride, 7 and silica gel, 8 etc., each of which has its own merits and drawbacks.…”