A new method for loading mesoporous silica nanoparticles with drugs: Sol–gel synthesis using drug micelles as a template

Дементьева, О. В.; Senchikhin, I. N.; Kartseva, M. E.; Ogarev, V. A.; Зайцева, А. В.; Matushkina, N. N.; Rudoy, V. M.

doi:10.1134/s1061933x16050045

Cited by 25 publications

(7 citation statements)

References 32 publications

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“…The sol-gel approach allows a simultaneous synthesis of MSNs and their loading with an amphiphilic biologically active compound that works as a template. It was developed for miramistin but might be easily extended by using micelles or vesicles of other active compounds, providing a very effective one-stage production of loaded particles [ 270 ]. Unfortunately, even though the above mentioned loading methods are sufficient for laboratory purposes, there is a need to focus on the development of the scale-up processes for simplified and cost-effective commercial manufacturing.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Mesoporous Silica Particles as Drug Delivery Systems—The State of the Art in Loading Methods and the Recent Progress in Analytical Techniques for Monitoring These Processes

et al. 2021

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Conventional administration of drugs is limited by poor water solubility, low permeability, and mediocre targeting. Safe and effective delivery of drugs and therapeutic agents remains a challenge, especially for complex therapies, such as cancer treatment, pain management, heart failure medication, among several others. Thus, delivery systems designed to improve the pharmacokinetics of loaded molecules, and allowing controlled release and target specific delivery, have received considerable attention in recent years. The last two decades have seen a growing interest among scientists and the pharmaceutical industry in mesoporous silica nanoparticles (MSNs) as drug delivery systems (DDS). This interest is due to the unique physicochemical properties, including high loading capacity, excellent biocompatibility, and easy functionalization. In this review, we discuss the current state of the art related to the preparation of drug-loaded MSNs and their analysis, focusing on the newest advancements, and highlighting the advantages and disadvantages of different methods. Finally, we provide a concise outlook for the remaining challenges in the field.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Mesoporous Silica Particles as Drug Delivery Systems—The State of the Art in Loading Methods and the Recent Progress in Analytical Techniques for Monitoring These Processes

et al. 2021

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“…On the other hand, several previous reports have described the use of different active molecules (e.g., a corrosion inhibitor, an antitumor drug, etc.) as templates for the synthesis of various porous silica materials. − Although numerous advantages of one-step fabrication of DDSs have been realized through these works, there have been only a few reports involving those with antimicrobial applications, and the efficacy of the fabricated materials is often not evaluated beyond the scope of drug release kinetics.…”

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confidence: 99%

“…In phosphate-buffered saline (PBS) pH 7.4, n = 0.72, which is indicative of non-Fickian diffusion with a superposition of framework swelling or erosion . However, in PBS solutions acidified with HCl to pH 4.0, 5.0, and 6.5, n values ranged between 0.13 and 0.18 which suggests non-Fickian diffusion from disordered pores with respect to shape, length, and size. , It is noteworthy that the dependence of n values to the release should, in reality, comprise several superimposed processes. For example, penetration of water into the particles is present in both release media, but it is more profound in PBS without HCl.…”

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confidence: 99%

One-Pot Hydrothermal Synthesis of Benzalkonium-Templated Mesostructured Silica Antibacterial Agents

et al. 2018

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Novel mesostructured silica microparticles are synthesized, characterized and investigated as a drug delivery system (DDS) for antimicrobial applications. The materials exhibit relatively high density (0.56 g per 1 g SiO2) of BAC, pore channels of 18 Å in width, and high surface area (1500 m2/g). Comparison of SAXRD pattern with BJH pore size distribution data suggests that the 18 Å pores exhibit short range ordering and a wall thickness of ca. 12 Å. Drug release studies demonstrate pH-responsive controlled release of BAC without additional surface modification of the materials. Prolonged drug release data was analyzed using a power law (Korsmeyer-Peppas) model and indicates substantial differences in release mechanism in acidic (pH 4.0, 5.0, 6.5) versus neutral (pH 7.4) solutions. Microbiological assays demonstrate a significant time-dependent reduction in Staphylococcus aureus and Salmonella enterica viability above 10 and 130 mg L−1 of the synthesized materials, respectively. The viability of cells is reduced over time compared to control samples. The findings will help in widening the use of BAC as a disinfectant and bactericidal agent, especially in pharmaceutical and food industries where Gram-positive and Gram-negative bacterial contamination is common.

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“…The findings of higher drug loading are in consonance with the previous reports of drug loading of mesoporous silica nanocarriers. 39…”

Section: Resultsmentioning

confidence: 99%

Albumin-Coated Mesoporous Silica Nanoparticles of Docetaxel: Preparation, Characterization, and Pharmacokinetic Evaluation

Pandita

Munjal

Poonia

et al. 2021

ASSAY and Drug Development Technologies

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A new method for loading mesoporous silica nanoparticles with drugs: Sol–gel synthesis using drug micelles as a template

Cited by 25 publications

References 32 publications

Mesoporous Silica Particles as Drug Delivery Systems—The State of the Art in Loading Methods and the Recent Progress in Analytical Techniques for Monitoring These Processes

Mesoporous Silica Particles as Drug Delivery Systems—The State of the Art in Loading Methods and the Recent Progress in Analytical Techniques for Monitoring These Processes

One-Pot Hydrothermal Synthesis of Benzalkonium-Templated Mesostructured Silica Antibacterial Agents

Albumin-Coated Mesoporous Silica Nanoparticles of Docetaxel: Preparation, Characterization, and Pharmacokinetic Evaluation

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