Albumin-Coated Mesoporous Silica Nanoparticles of Docetaxel: Preparation, Characterization, and Pharmacokinetic Evaluation

Pandita, Deepti; Munjal, Aman; Poonia, Neelam; Awasthi, Rajendra; Kalonia, Harikesh; Lather, Viney

doi:10.1089/adt.2020.1039

Cited by 16 publications

(5 citation statements)

References 41 publications

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“…To investigate the interaction between the drug and the carrier, about 2–3 mg of each sample was mixed with dried potassium bromide and pressed via an infrared tablet press at 800 MPa for 2 min. The sample pellets were scanned from 4000 to 400 cm –1 at the resolution by a FT-IR spectrophotometer (IFS-55; Bruker GMBH, Germany) …”

Section: Materials and Methodsmentioning

confidence: 99%

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Human Serum Albumin Nanoparticles as a Carrier of 20(S)-Protopanaxadiol via Intramuscular Injection to Alleviate Cyclophosphamide-Induced Myelosuppression

Liu,

Yang,

Yuan

et al. 2023

Mol. Pharmaceutics

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Section: Materials and Methodsmentioning

confidence: 99%

“…The sample pellets were scanned from 4000 to 400 cm −1 at the resolution by a FT-IR spectrophotometer (IFS-55; Bruker GMBH, Germany). 35 2.3.7. In Vitro Drug Release.…”

Section: Fourier Transform Infrared Spectroscopy (Ft-ir)mentioning

confidence: 99%

Human Serum Albumin Nanoparticles as a Carrier of 20(S)-Protopanaxadiol via Intramuscular Injection to Alleviate Cyclophosphamide-Induced Myelosuppression

Liu,

Yang,

Yuan

et al. 2023

Mol. Pharmaceutics

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“…Folic acid has also been considered due to its interaction with the folate receptors of cancer cells [136]. Due to its expansive surface area, considerable porosity, robust mechanical and chemical stability, and suitable biocompatibility, mesoporous silica, characterized by its hollow interior, has gained recognition [137]. Mesoporous polydopamine is also one of the other NPs that have received attention due to its biodegradability, compatibility with different tissues, favorable magnetic and electro-optical properties in cancer treatment, and the release of chemotherapy drugs [135].…”

Section: Techniques Used For Encapsulating Docetaxel In Nanoparticlesmentioning

confidence: 99%

Boosting antitumor efficacy using docetaxel-loaded nanoplatforms: from cancer therapy to regenerative medicine approaches

Beheshtizadeh,

Amiri,

Tabatabaei

et al. 2024

J Transl Med

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The intersection of nanotechnology and pharmacology has revolutionized the delivery and efficacy of chemotherapeutic agents, notably docetaxel, a key drug in cancer treatment. Traditionally limited by poor solubility and significant side effects, docetaxel’s therapeutic potential has been significantly enhanced through its incorporation into nanoplatforms, such as nanofibers and nanoparticles. This advancement offers targeted delivery, controlled release, and improved bioavailability, dramatically reducing systemic toxicity and enhancing patient outcomes. Nanofibers provide a versatile scaffold for the controlled release of docetaxel, utilizing techniques like electrospinning to tailor drug release profiles. Nanoparticles, on the other hand, enable precise drug delivery to tumor cells, minimizing damage to healthy tissues through sophisticated encapsulation methods such as nanoprecipitation and emulsion. These nanotechnologies not only improve the pharmacokinetic properties of docetaxel but also open new avenues in regenerative medicine by facilitating targeted therapy and cellular regeneration. This narrative review highlights the transformative impact of docetaxel-loaded nanoplatforms in oncology and beyond, showcasing the potential of nanotechnology to overcome the limitations of traditional chemotherapy and pave the way for future innovations in drug delivery and regenerative therapies. Through these advancements, nanotechnology promises a new era of precision medicine, enhancing the efficacy of cancer treatments while minimizing adverse effects. Graphical Abstract

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“…Because of all of the above-mentioned characteristics, albumin coating has been combined with other molecules or synthetic polymers in order to obtain effective drug delivery systems with MSNs as nanocarriers [ 158 , 259 , 267 ]. Most of them have been studied for the transport of anticancer drugs with poor pharmacokinetic profile and metabolic stability such as DOX, PTX, and DTX, among others [ 263 , 268 ].…”

Section: Functionalization Of Msns With Biopolymersmentioning

confidence: 99%

Natural Biopolymers as Smart Coating Materials of Mesoporous Silica Nanoparticles for Drug Delivery

et al. 2023

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In recent years, the functionalization of mesoporous silica nanoparticles (MSNs) with different types of responsive pore gatekeepers have shown great potential for the formulation of drug delivery systems (DDS) with minimal premature leakage and site-specific controlled release. New nanotechnological approaches have been developed with the objective of utilizing natural biopolymers as smart materials in drug delivery applications. Natural biopolymers are sensitive to various physicochemical and biological stimuli and are endowed with intrinsic biodegradability, biocompatibility, and low immunogenicity. Their use as biocompatible smart coatings has extensively been investigated in the last few years. This review summarizes the MSNs coating procedures with natural polysaccharides and protein-based biopolymers, focusing on their application as responsive materials to endogenous stimuli. Biopolymer-coated MSNs, which conjugate the nanocarrier features of mesoporous silica with the biocompatibility and controlled delivery provided by natural coatings, have shown promising therapeutic outcomes and the potential to emerge as valuable candidates for the selective treatment of various diseases.

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Albumin-Coated Mesoporous Silica Nanoparticles of Docetaxel: Preparation, Characterization, and Pharmacokinetic Evaluation

Cited by 16 publications

References 41 publications

Human Serum Albumin Nanoparticles as a Carrier of 20(S)-Protopanaxadiol via Intramuscular Injection to Alleviate Cyclophosphamide-Induced Myelosuppression

Human Serum Albumin Nanoparticles as a Carrier of 20(S)-Protopanaxadiol via Intramuscular Injection to Alleviate Cyclophosphamide-Induced Myelosuppression

Boosting antitumor efficacy using docetaxel-loaded nanoplatforms: from cancer therapy to regenerative medicine approaches

Natural Biopolymers as Smart Coating Materials of Mesoporous Silica Nanoparticles for Drug Delivery

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