A new method for improving the accuracy of miRNA detection with NaYF4:Yb,Er upconversion nanoparticles

Mao, Lanlan; Lu, Zhuoxuan; He, Nongyue; Zhang, Liming; Deng, Yan; Duan, Deming

doi:10.1007/s11426-016-0021-0

Cited by 30 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lanthanide-doped UCNPs are fluorescent inorganic nanomaterials that can absorb two or more low-energy photons light to produce higher energy photons and emit fluorescence signals [152] , [153] , [154] . Compared with conventional fluorescent materials, UCNPs have a variety of advantages, such as low toxicity, long luminescence lifetimes, high photostability, high signal-to-noise ratio, and high resistance to photobleaching [155] , [156] , [157] , and thus have been regarded as a kind of very promising fluorescent probes for POC detection of infectious diseases.…”

Section: Detection Methods For Poc Diagnostic Applicationsmentioning

confidence: 99%

Point-of-care diagnostics for infectious diseases: From methods to devices

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Detection Methods For Poc Diagnostic Applicationsmentioning

confidence: 99%

Point-of-care diagnostics for infectious diseases: From methods to devices

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, the transfer to an organic solvent leads to fluorescence quenching, and surface hydrophilic modification of UCNPs seems imperative [ 107 ]. Methods for producing hydrophilic modifications usually involve adding (1) acidic ligands [ 108 ] (2) polymers [ 109 ] or (3) chelating agents [ 110 ], and these ligands usually have hydrophilic functional groups, such as a hydroxyl group, primary or secondary amine, and carboxylic acid, etc. When citrate acid is used as a growth control agent in hydrothermal synthesis, the resulting UCNP’s shape and size can be controlled and evenly dispersed in aqueous solution by adjusting the ratio [ 111 ].…”

Section: Synthesis and Functionalization Of Upconversion Nanomaterialmentioning

confidence: 99%

Recent progress in the development of upconversion nanomaterials in bioimaging and disease treatment

et al. 2020

View full text Add to dashboard Cite

Multifunctional lanthanide-based upconversion nanoparticles (UCNPs), which feature efficiently convert low-energy photons into high-energy photons, have attracted considerable attention in the domain of materials science and biomedical applications. Due to their unique photophysical properties, including light-emitting stability, excellent upconversion luminescence efficiency, low autofluorescence, and high detection sensitivity, and high penetration depth in samples, UCNPs have been widely applied in biomedical applications, such as biosensing, imaging and theranostics. In this review, we briefly introduced the major components of UCNPs and the luminescence mechanism. Then, we compared several common design synthesis strategies and presented their advantages and disadvantages. Several examples of the functionalization of UCNPs were given. Next, we detailed their biological applications in bioimaging and disease treatment, particularly drug delivery and photodynamic therapy, including antibacterial photodynamic therapy. Finally, the future practical applications in materials science and biomedical fields, as well as the remaining challenges to UCNPs application, were described. This review provides useful practical information and insights for the research on and application of UCNPs in the field of cancer.

show abstract

“…Wen et al [27] developed an ultrasensitive DNA nanostructure-based electrochemical miRNA biosensor, which can directly detect as few as attomolar (<1000 copies) miRNAs with high single-base discrimination ability. Mao et al [28] developed a simpler method for miRNA detection based on base stacking hybridization happening on the surface of NaYF4: Yb, Er up conversion nano particles.…”

Section: Juniper Online Journal Materials Sciencementioning

confidence: 99%

Nano Materials for Early Detection of Cancer

Wang¹

2017

JOJMS

View full text Add to dashboard Cite

Cancer is one of the leading causes of morbidity and mortality worldwide, more than 600 000 people die annually in the US along. In reality, no matter what kind of cancer, the survival rate is much higher and the expense is much lower for people diagnosed with early stage cancer than with later stage cancer. However, current clinical techniques are difficult to detect cancer in the early stage, due to their small size and the fact that they are hidden very deep. Nano materials provide incredible properties, such as high relative surface area, quantum confinement, etc., which have been largely used for early detection. This mini review gives a simple overview of current progress in the field of nano materials for early detection of cancer.

show abstract

A new method for improving the accuracy of miRNA detection with NaYF4:Yb,Er upconversion nanoparticles

Cited by 30 publications

References 37 publications

Point-of-care diagnostics for infectious diseases: From methods to devices

Point-of-care diagnostics for infectious diseases: From methods to devices

Recent progress in the development of upconversion nanomaterials in bioimaging and disease treatment

Nano Materials for Early Detection of Cancer

Contact Info

Product

Resources

About