A new method for detection of five alternaria toxins in food matrices based on LC–APCI-MS

Prelle, A.; Spadaro, D.; Garibaldi, A.; Gullino, M. L.

doi:10.1016/j.foodchem.2012.12.065

Cited by 80 publications

(60 citation statements)

References 22 publications

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“…Due to their structural and toxicological similarity to the well-studied fumonisins, they are nevertheless included in this study. ALT has been found in linseed in low levels in the Czech Republic by Králová et al (2006) and in apple juice, tomato products and beers by Prelle et al (2013). The presence of isoALT has not been reported to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 77%

Survey of Alternaria toxin contamination in food from the German market, using a rapid HPLC-MS/MS approach

et al. 2015

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A HPLC-MS/MS-based method for the quantification of nine mycotoxins produced by fungi of the genus Alternaria in various food matrices was developed. The method relies on a single-step extraction, followed by dilution of the raw extract and direct analysis. In combination with an analysis time per sample of 12 min, the sample preparation is cost-effective and easy to handle. The method covers alternariol (AOH), alternariol monomethyl ether (AME), tenuazonic acid (TeA), altenuene (ALT), iso-altenuene (isoALT), tentoxin (TEN), altertoxin-I (ATX-I), and the AAL toxins TA1 and TA2. Some Alternaria toxins which are either not commercially available or very expensive, namely AOH, AME, ALT, isoALT, and ATX-I, were isolated as reference compounds from fungal cultures. The method was extensively validated for tomato products, bakery products, sunflower seeds, fruit juices, and vegetable oils. AOH, AME, TeA, and TEN were found in quantifiable amounts and 92.1% of all analyzed samples (n = 96) showed low level contamination with one or more Alternaria toxins. Based on the obtained results, the average daily exposure to Alternaria toxins in Germany was calculated.

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Section: Introductionmentioning

confidence: 77%

Survey of Alternaria toxin contamination in food from the German market, using a rapid HPLC-MS/MS approach

et al. 2015

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“…The LOD was calculated as the lowest concentration of the analyte giving a peak area 3 times greater than the area of the baseline noise of a blank (unspiked) sample (S/N P 3). The LOQ was defined as the lowest concentration of the toxin in which the signal to noise ratio (S/N) was equal to 10 (Prelle et al, 2013).…”

Section: Validation Of the Methodsmentioning

confidence: 99%

“…It has been suggested that the increased incidence of human esophageal cancer in China was correlated with the contamination of cereals with Alternaria alternata toxins (Liu et al, 1992 The occurrence of Alternaria toxins has been previously reported in various raw and processed products. Particularly, these mycotoxins were detected among others in tomatoes and tomato products (Noser, Schneider, Rother, & Schmutz, 2011), in apples and apple products (Andersen, Smedsgaard, Jorring, Skouboe, & Pedersen, 2006), carrots (Solfrizzo, De Girolamo, Vitti, Visconti, & van den Bulk, 2004), soya beans (Oviedo, Barros, Chulze, & Ramirez, 2012), pepper products (Lohrey, Marschik, Cramer, & Humpf, 2013), cereals (Müller & Korn, 2013), olives (Visconti, Logrieco, & Bottalico, 1986), citrus fruits (Magnani, De Souza, & Rodrigues-Filho, 2007), cornflakes (Aresta, Cioffi, Palmisano, & Zambonin, 2003), beers (Prelle, Spadaro, Garibaldi, & Gullino, 2013), fruit juices and beverages (Lau et al, 2003), and wines (Broggi et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Determination of mycotoxins in pomegranate fruits and juices using a QuEChERS-based method

et al. 2015

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“…Consequently, Alternaria mycotoxins were detected in cereals and derived products [46,[57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76], feed [74,[109][110][111][112][113], dairy products [114], grapes and by-products [27,77,115], tomatoes and derived products [31,47,77,81,106,113], nuts and by-products [102,116], spices [117], soybeans [76,116,118], sunflower seeds [85,104,107], vegetables [27,101], vegetable oils [105], strawberries …”

Section: Prevalence Of Alternaria Mycotoxinsmentioning

confidence: 99%

AlternariaMycotoxins in Food and Feed: An Overview

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Oueslati

Font

et al. 2017

Journal of Food Quality

132

127

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Alternaria is one of the major mycotoxigenic fungal genera with more than 70 reported metabolites. Alternaria mycotoxins showed notably toxicity, such as mutagenicity, carcinogenicity, induction of DNA strand break, sphingolipid metabolism disruption, or inhibition of enzymes activity and photophosphorylation. This review reports on the toxicity, stability, metabolism, current analytical methods, and prevalence of Alternaria mycotoxins in food and feed through the most recent published research. Half of the publications were focused on fruits, vegetables, and derived products-mainly tomato and apples-while cereals and cereal byproducts represented 38%. The most studied compounds were alternariol, alternariol methyl ether, tentoxin, and tenuazonic acid, but altenuene, altertoxins (I, II, and III), and macrosporin have been gaining importance in recent years. Solid-liquid extraction (50%) with acetonitrile or ethyl acetate was the most common extraction methodology, followed by QuEChERS and dilutiondirect injection (both 14%). High-and ultraperformance liquid chromatography coupled with tandem mass spectrometry was the predominant determination technique (80%). The highest levels of alternariol and alternariol methyl ether were found in lentils, oilseeds, tomatoes, carrots, juices, wines, and cereals. Tenuazonic acid highest levels were detected in cereals followed by beer, while alternariol, alternariol methyl ether, tenuazonic acid, and tentoxin were found in legumes, nuts, and oilseeds.

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A new method for detection of five alternaria toxins in food matrices based on LC–APCI-MS

Cited by 80 publications

References 22 publications

Survey of Alternaria toxin contamination in food from the German market, using a rapid HPLC-MS/MS approach

Survey of Alternaria toxin contamination in food from the German market, using a rapid HPLC-MS/MS approach

Determination of mycotoxins in pomegranate fruits and juices using a QuEChERS-based method

AlternariaMycotoxins in Food and Feed: An Overview

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