A new method for correcting axial dispersion in GPC

Marais, L.; Gallot, Z.; Benoît, H.

doi:10.1002/app.1977.070210721

Cited by 23 publications

(8 citation statements)

References 2 publications

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“…In all cases, a sharp monomodal peak with a narrow molecular weight distribution (1.005< M w / M n <1.01) was observed. It should be noted that the apparent polydispersity index of monodisperse polymers is never equal to 1 in SEC because of axial dispersion and peak broadening 24 25 . Moreover, the molecular structure of the oligo(alkoxyamine amide)s was confirmed with NMR analysis ( Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

Design and synthesis of digitally encoded polymers that can be decoded and erased

et al. 2015

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Biopolymers such as DNA store information in their chains using controlled sequences of monomers. Here we describe a non-natural information-containing macromolecule that can store and retrieve digital information. Monodisperse sequence-encoded poly(alkoxyamine amide)s were synthesized using an iterative strategy employing two chemoselective steps: the reaction of a primary amine with an acid anhydride and the radical coupling of a carbon-centred radical with a nitroxide. A binary code was implemented in the polymer chains using three monomers: one nitroxide spacer and two interchangeable anhydrides defined as 0-bit and 1-bit. This methodology allows encryption of any desired sequence in the chains. Moreover, the formed sequences are easy to decode using tandem mass spectrometry. Indeed, these polymers follow predictable fragmentation pathways that can be easily deciphered. Moreover, poly(alkoxyamine amide)s are thermolabile. Thus, the digital information encrypted in the chains can be erased by heating the polymers in the solid state or in solution.

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Section: Resultsmentioning

confidence: 99%

Design and synthesis of digitally encoded polymers that can be decoded and erased

et al. 2015

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“…In addition, some correction for axial dispersion should be applied. To resolve both of these, we chose to use the method of Marais et al 29 The use of this method has previously been described in detail. 28 It is sufficient to note that, although a may vary with the molecular weight for a branched polymer, the method is insensitive to the exact value of the a and consequently an average may be used.…”

Section: Gel Permeation Chromatography On-line With Low-angle Laser Lmentioning

confidence: 99%

Molecular characterization and effect of shear on the distribution of long branching in poly(vinyl acetate)

Agarwal¹,

Jenkins²,

Poster³

1982

J. Appl. Polym. Sci.

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SynopsisPoly(viny1 acetate) (WAC) of xw 750,000 xw/?&, 3.85 and En (the number of long branches per molecule) 2.2 was subjected to chain scission by mechanical (high-speed stirring) as well as chemical (saponification and reacetylation) methods to investigate the effect of shear on the branching distribution. The extent of long branching was measured by gel permeation chromatography on-line with low-angle laser light scattering photometry. It was concluded that (i) the branches through the acetate group are long and are ruptured preferentially on shearing, (ii) the branches through the a-and @-carbons are not broken on shearing, (iii) the extent of long branching through the acetate group is about 67% of total branching, and (iv) the poly(viny1 alcohol) derived from branched PVAc contains a smaller but nevertheless significant amount of branching.

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“…The targeted oligomer was predominantly detected in MS, and a symmetric chromatogram was observed in SEC, although the apparent dispersity Đ was found to be 1.01. It shall be reminded that due to axial dispersion and peak broadening 25,26 the apparent dispersity of a uniform polymer cannot be equal to 1 in SEC measurements. The number-average molecular weight M n was also found to be close to the theoretical value, thus indicating that polystyrene (PS) calibration is somewhat accurate for poly(N-substituted urethanes).…”

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Efficient Protocol for the Synthesis of “N-Coded” Oligo- and Poly(N-Substituted Urethanes)

et al. 2019

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Sequence-defined poly(N-substituted urethanes) were synthesized via a solid-phase iterative protocol including two successive orthogonal coupling steps: the formation of an activated carbonate and its chemoselective reaction with the secondary amine group of amino alcohol building blocks. This simple method was used to write binary information on the formed polymers using four-coded molecules, 2-(methylamino)ethanol, 2-(ethylamino)ethanol, 2-(propylamino)ethanol, and 2-(butylamino)ethanol, symbolizing binary dyads 00, 01, 10, and 11, respectively. The method is fast and allows synthesis of uniform oligomers and polymers with controlled lengths (4-mer to 28-mer) and digital information sequences. Furthermore, the coded poly(N-substituted urethanes) were easily characterized by electrospray mass spectrometry and decoded by tandem mass spectrometry. Overall, these digital macromolecules offer interesting advantages over conventional sequence-coded polyurethanes, i.e., synthesis of longer chains, reduced synthesis times, and better solubility and processing in common organic solvents.

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A new method for correcting axial dispersion in GPC

Cited by 23 publications

References 2 publications

Design and synthesis of digitally encoded polymers that can be decoded and erased

Design and synthesis of digitally encoded polymers that can be decoded and erased

Molecular characterization and effect of shear on the distribution of long branching in poly(vinyl acetate)

Efficient Protocol for the Synthesis of “N-Coded” Oligo- and Poly(N-Substituted Urethanes)

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