Design and synthesis of digitally encoded polymers that can be decoded and erased

Roy, Raj Kumar; Meszyńska, Anna; Laure, Chloé; Charles, Laurence; Verchin, Claire; Lutz, Jean‐François

doi:10.1038/ncomms8237

Cited by 281 publications

(299 citation statements)

References 46 publications

Supporting

Mentioning

292

Contrasting

Unclassified

Order By: Relevance

“…Beyond, the present theory can also be applied to study the autonomous processes of living copolymerization with a template [37], or the cyclic processes used for the synthesis of sequence-controlled copolymers with encoded information [44,45].…”

Section: Discussionmentioning

confidence: 99%

Growth and Dissolution of Macromolecular Markov Chains

Gaspard

2016

J Stat Phys

View full text Add to dashboard Cite

The kinetics and thermodynamics of free living copolymerization are studied for processes with rates depending on k monomeric units of the macromolecular chain behind the unit that is attached or detached. In this case, the sequence of monomeric units in the growing copolymer is a k th -order Markov chain. In the regime of steady growth, the statistical properties of the sequence are determined analytically in terms of the attachment and detachment rates. In this way, the mean growth velocity as well as the thermodynamic entropy production and the sequence disorder can be calculated systematically. These different properties are also investigated in the regime of depolymerization where the macromolecular chain is dissolved by the surrounding solution. In this regime, the entropy production is shown to satisfy Landauer's principle.

show abstract

Section: Discussionmentioning

confidence: 99%

Growth and Dissolution of Macromolecular Markov Chains

Gaspard

2016

J Stat Phys

View full text Add to dashboard Cite

show abstract

“…Much work in SRP research makes use of controlled radical and other living type reactions [9][10][11][12][13][14] nucleobase polymers [15,16], and information containing polymers [17,18].…”

Section: Background and Motivationmentioning

confidence: 99%

Simultaneous Monitoring of the Effects of Multiple Ionic Strengths on Properties of Copolymeric Polyelectrolytes during Their Synthesis

Zhu

Drenski³

et al. 2017

Processes

View full text Add to dashboard Cite

Abstract:A new Automatic Continuous Online Monitoring of Polymerization reactions (ACOMP) system has been developed with multiple light scattering and viscosity detection stages in serial flow, where solution conditions are different at each stage. Solution conditions can include ionic strength (IS), pH, surfactants, concentration, and other factors. This allows behavior of a polymer under simultaneous, varying solution conditions to be monitored at each instant of its synthesis. The system can potentially be used for realtime formulation, where a solution formulation is built up additively in successive stages. It can also monitor the effect of solution conditions on stimuli responsive polymers, as their responsiveness changes during synthesis. In this first work, the new ACOMP system monitored light scattering and reduced viscosity properties of copolymeric polyelectrolytes under various IS during synthesis. Aqueous copolymerization of acrylamide (Am) and styrene sulfonate (SS) was used. Polyelectrolytes in solution expand as IS decreases, leading to increased intrinsic viscosity (η) and suppression of light scattering intensity due to electrostatically enhanced second and third virial coefficients, A 2 and A 3 . At a fixed IS, the same effects occur if polyelectrolyte linear charge density (ξ) increases. This work presents polyelectrolyte response to a series of IS and changing ξ during chemical synthesis.Keywords: ACOMP; online monitoring; copolymeric polyelectrolytes; light scattering; viscosity Background and MotivationThis work introduces a new version of the Automatic Continuous Online Monitoring of Polymerization reactions (ACOMP) system ("second generation ACOMP") whose aim is to monitor the onset and evolution of stimuli responsive behavior, under multiple simultaneous solution conditions, during the synthesis of stimuli responsive polymers (SRP). SRP is a vast area of modern polymer science and engineering, aimed at producing polymers that can respond to such stimuli as temperature, radiation, and solution conditions such as pH, ionic strength, polymer concentration, presence of such agents as surfactants, nanoparticles, hydrophobic species, etc. The types of responses that can occur in response to these stimuli include coil/globule phase transitions, polymer coil expansion or shrinkage, micellization, aggregation, and other forms of spontaneous self-assembly.These next-generation materials are expected to have applications in medicine, sensors, self-healing materials, and environmental remediation [1][2][3][4][5]. Hydrogels ofpoly(N-isopropylacrylamide), for example, have a lower critical solution temperature (LCST), near body temperature, which makes it a candidate for drug delivery applications in which the NIPAM-based polymer releases its medical

show abstract

“…Although these powerful methods have enabled transformative advances in biotechnology and have recently been revisited for the synthesis of sequencedefined synthetic polymers (14)(15)(16), alternative strategies are needed that provide a general solution for access to sequencedefined synthetic polymers in a scalable and sustainable manner. In contrast, step-or chain-growth polymerization methods that use differences in monomer reactivity, living polymerizations, monomer design, and/or templating strategies to impart sequence regulation have been recently reported (17)(18)(19)(20)(21)(22)(23).…”

mentioning

confidence: 99%

Scalable synthesis of sequence-defined, unimolecular macromolecules by Flow-IEG

Leibfarth

Johnson

Jamison

2015

Proc. Natl. Acad. Sci. U.S.A.

162

120

View full text Add to dashboard Cite

We report a semiautomated synthesis of sequence and architecturally defined, unimolecular macromolecules through a marriage of multistep flow synthesis and iterative exponential growth (Flow-IEG). The Flow-IEG system performs three reactions and an in-line purification in a total residence time of under 10 min, effectively doubling the molecular weight of an oligomeric species in an uninterrupted reaction sequence. Further iterations using the Flow-IEG system enable an exponential increase in molecular weight. Incorporating a variety of monomer structures and branching units provides control over polymer sequence and architecture. The synthesis of a uniform macromolecule with a molecular weight of 4,023 g/mol is demonstrated. The user-friendly nature, scalability, and modularity of Flow-IEG provide a general strategy for the automated synthesis of sequence-defined, unimolecular macromolecules. Flow-IEG is thus an enabling tool for theory validation, structure-property studies, and advanced applications in biotechnology and materials science.polymers | automation | continuous flow chemistry | unimolecular macromolecules | sequence-controlled polymers

show abstract

Design and synthesis of digitally encoded polymers that can be decoded and erased

Cited by 281 publications

References 46 publications

Growth and Dissolution of Macromolecular Markov Chains

Growth and Dissolution of Macromolecular Markov Chains

Simultaneous Monitoring of the Effects of Multiple Ionic Strengths on Properties of Copolymeric Polyelectrolytes during Their Synthesis

Scalable synthesis of sequence-defined, unimolecular macromolecules by Flow-IEG

Contact Info

Product

Resources

About