A new measuring and identification approach for time-varying bioimpedance using multisine electrical impedance spectroscopy

Sanchez, Benjamin; Louarroudi, Ebrahim; Jorge, Esther; Cinca, Juan; Bardia, Ramon Bragós; Pintelon, R.

doi:10.1088/0967-3334/34/3/339

Cited by 66 publications

(58 citation statements)

References 39 publications

(56 reference statements)

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“…The muscle impedance was measured using a custom broadband impedance frequency response analyzer (FRA) [12], [15], [16]. The impedance measurement system was implemented on a rugged PC-platform PXI (PCI eXtensions for Instrumentation) platform from National Instruments.…”

Section: E Impedance Measurementmentioning

confidence: 99%

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Impedance Alterations in Healthy and Diseased Mice During Electrically Induced Muscle Contraction

Sanchez

Geisbush

et al. 2016

IEEE Trans. Biomed. Eng.

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Abstract-Alterations in the health of muscles can be evaluated through the use of electrical impedance myography (EIM). To date, however, nearly all work in this field has relied upon the measurement of muscle at rest. To provide insight into the contractile mechanisms of healthy and disease muscle, we evaluated the alterations in the spectroscopic impedance behavior of muscle during the active process of muscle contraction. The gastrocnemii from a total of 13 mice were studied (5 wild type, 4 muscular dystrophy animals, and 4 amyotrophic lateral sclerosis animals). Muscle contraction was induced via monophasic current pulse stimulation of the sciatic nerve. Simultaneously, multisine EIM (1 kHz to 1 MHz) and force measurements of the muscle were performed. Stimulation was applied at 3 different rates to produce mild, moderate and strong contractions. We identified changes in both single and multifrequency data, as assessed by the Cole impedance model parameters. The processes of contraction and relaxation were clearly identified in the impedance spectra and quantified via derivative plots. Reductions in the center frequency f c were observed during the contraction consistent with increasing muscle fiber diameter. Different EIM stimulation rate-dependencies were also detected across the 3 groups of animals.

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Section: E Impedance Measurementmentioning

confidence: 99%

“…To perform simultaneous EIM spectroscopy measurements (1 kHz to 1 MHz), multisine impedance spectroscopy is used [12]. To fully achieve time-synchronization, both the force exerted by the muscle and the nerve stimuli applied are recorded simultaneously to the muscle impedance measurement.…”

mentioning

confidence: 99%

Impedance Alterations in Healthy and Diseased Mice During Electrically Induced Muscle Contraction

Sanchez

Geisbush

et al. 2016

IEEE Trans. Biomed. Eng.

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“…based on multisines signals [10], [11], [12]. Using the multifrequency approach, many frequencies are applied simultaneously (B) and the time to acquire a complete EIM spectrum is drastically reduced making it possible to measure the instantaneous impedance changes and temporal evolution of dynamic EIM, for example, during muscle contraction and relaxation and to collect both nonand fatigued muscle data.…”

Section: Impedance Instrumentationmentioning

confidence: 99%

“…The muscle impedance was measured using the custom broadband impedance frequency response analyzer (FRA) used in [11], [12]. The impedance measurement system was implemented on a rugged PC-platform PXI (PCI eXtensions for Instrumentation) platform from National Instruments.…”

Section: Impedance Measurementmentioning

confidence: 99%

A pilot spectroscopy study on time-varying bioimpedance during electrically-induced muscle contraction

Sanchez

Geisbush

et al. 2014

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Alterations in the health of muscles can be evaluated through the use of electrical impedance myography (EIM). To date, however, nearly all work has relied upon single-frequency/spectroscopy stepped-sine measurements of static muscle (contracted or relaxed). In this work, we assessed the temporal alterations in the impedance spectrum (1 kHz to 1 MHz) behavior of gastrocnemius during the active process of muscle contraction. The approach is based on the multisine impedance spectroscopy technique. The gastrocnemii of a wild type mouse was measured during electrically-induced muscle contraction via direct current stimulation of the sciatic nerve. The processes of contraction and relaxation were clearly identified in the time-frequency impedance spectrum likely corresponding to an increase muscle fiber diameter. The technique of dynamic multisine EIM has the potential of providing useful insights into contractile mechanisms of muscle in health and disease.

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“…Sanchez et al have recently introduced a new measuring approach based on multi-sine EBIS for time-varying bioimpedance monitoring [14]. This method and other multi-frequency excitation methods allows for higher sampling rates of the EBIS signal.…”

Section: Introductionmentioning

confidence: 99%

Electrical bioimpedance spectroscopy in time-variant systems: Is undersampling always a problem?

Abtahi

Seoane

Lindecrantz

2014

Journal of Electrical Bioimpedance

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During the last decades, Electrical Bioimpedance Spectroscopy (EBIS) has been applied mainly by using the frequency-sweep technique, across a range of many different applications. Traditionally, the tissue under study is considered to be timeinvariant and dynamic changes of tissue activity are ignored by treating the changes as a noise source. A new trend in EBIS is simultaneous electrical stimulation with several frequencies, through the application of a multi-sine, rectangular or other waveform. This method can provide measurements fast enough to sample dynamic changes of different tissues, such as myocard. This high sampling rate comes at a price of reduction in SNR and the increase in complexity of devices. Although the frequencysweep technique is often inadequate for monitoring the dynamic changes in a variant system, it can be used successfully in applications focused on the time-invariant or slowly-variant part of a system. However, in order to successfully use frequencysweep EBIS for monitoring time-variant systems, it is paramount to consider the effects of aliasing and especially the folding of higher frequencies, on the desired frequency e.g. DC level. This paper discusses sub-Nyquist sampling of thoracic EBIS measurements and its application in the case of monitoring pulmonary oedema. It is concluded that by considering aliasing, and with proper implementation of smoothing filters, as well as by using random sampling, frequency-sweep EBIS can be used for assessing time-invariant or slowly-variant properties of timevariant biological systems, even in the presence of aliasing. In general, undersampling is not always a problem, but does always require proper consideration.

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A new measuring and identification approach for time-varying bioimpedance using multisine electrical impedance spectroscopy

Cited by 66 publications

References 39 publications

Impedance Alterations in Healthy and Diseased Mice During Electrically Induced Muscle Contraction

Impedance Alterations in Healthy and Diseased Mice During Electrically Induced Muscle Contraction

A pilot spectroscopy study on time-varying bioimpedance during electrically-induced muscle contraction

Electrical bioimpedance spectroscopy in time-variant systems: Is undersampling always a problem?

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