A new look at tamoxifen: co-administration with letrozole in intrauterine insemination cycles

Pourmatroud, Elham; Zargar, Mahvash; Nikbakht, Roshan; Moramazi, Farideh

doi:10.1007/s00404-012-2556-3

Cited by 6 publications

(6 citation statements)

References 19 publications

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“…Tamoxifen increased EMT during ovulation induction (OI), thus yielding low miscarriage rates and high live birth rates. 11,[13][14][15] Subsequently, patients with thin endometrium were reported to achieve improved embryo implantation after tamoxifen treatment in limited FET cycles. 16,17 At present, however, larger cohort studies aiming to elucidate the effect of tamoxifen on endometrial preparation have not been reported, and the efficacy of tamoxifen for different causes of thin endometrium remains elusive.…”

Section: Introductionmentioning

confidence: 99%

“…As a selective estrogen receptor (ER) modulator, tamoxifen exerts an antiestrogenic effect on breast tissue 11 and exerts estrogenic effects on bone mineral density, lipid profile, and the lower genital tract. The long-term use of tamoxifen in patients with breast cancer resulted in endometrial proliferation, including hyperplasia, polyps, carcinoma, and sarcoma.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Tamoxifen on Thin Endometrium in Patients Undergoing Frozen—Thawed Embryo Transfer

Jiang

Xia

et al. 2018

Reprod. Sci.

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Tamoxifen has played a vital role in endocrine therapy for the treatment of estrogen receptor-positive breast cancer. We examined the effect of tamoxifen in patients with a thin endometrium in frozen-thawed embryo transfer (FET) cycles and compared the improvement in endometrial thickness (EMT) and pregnancy outcomes stratified by different etiologies of thin endometrium. A total of 226 women were recruited for a new tamoxifen protocol; all had an EMT of less than 7.5 mm in previous cycles, including natural cycle (NC), hormone replacement treatment (HRT), and ovulation induction (OI) cycles. Compared with previous cycles, tamoxifen cycles showed a significantly increased EMT (from 6.11 ± 0.98 mm to 7.87 ± 1.48 mm in the NC group, from 6.24 ± 1.01 mm to 8.22 ± 1.67 mm in the HRT group, and from 6.34 ± 1.03 mm to 8.05 ± 1.58 mm in the OI group; all P < .001). Patients were further divided into 3 groups based on the causes of their thin endometrium: (1) history of intrauterine adhesion (n = 34), (2) history of uterine curettage (n = 141), and (3) polycystic ovary syndrome (PCOS; n = 51). Patients with PCOS obtained the thickest EMT (9.31 ± 1.55 mm), the lowest cycle cancellation rate (11.76%), and the highest rate of clinical pregnancy (60%) and live birth (55.56%) per transfer ( P < .001). Multivariable regression analysis showed that EMT was related to live birth (odds ratio: 1.487; 95% confidence interval: 1.172-1.887). A tamoxifen protocol improves EMT in patients after NC, HRT, and OI cycles during FET. Patients with PCOS show the most benefit from tamoxifen and achieve better pregnancy outcomes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Tamoxifen on Thin Endometrium in Patients Undergoing Frozen—Thawed Embryo Transfer

Jiang

Xia

et al. 2018

Reprod. Sci.

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“…Tamoxifen is a selective estrogen receptor modulator (SERM) used to treat breast cancer ( Pourmatroud et al ., 2013 ). Previous published studies showed that use of tamoxifen is associated with endometrial proliferation in women with breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Tamoxifen is a selective estrogen receptor modulator (SERM) that it’s approved as a highly effective agent for the prevention and treatment of breast cancer ( Pourmatroud et al ., 2013 ). In addition, tamoxifen has been used to induce ovulation ( Reynolds et al ., 2010 ; Seyedoshohadaei et al ., 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Comparison of tamoxifen and hormone replacement cycle (HRT) in frozen embryo transfer. A randomized controlled trial

Ebrahimi¹,

Mahmoudinia²,

Khadem³

et al. 2022

JBRA

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Objective: The use of frozen embryos in the treatment of infertility with assisted reproductive techniques has been increased. Different methods are used to prepare the endometrium for frozen embryo transfer (FET). The aim of this study was to compare pregnancy outcomes after treatment with tamoxifen and hormonal replacement therapy (HRT) in FET.Methods: This randomized clinical trial was carried out with 214 infertile women in the infertility research center of Milad Hospital in Mashhad during 2018-2020. We had 84 patients receiving tamoxifen and 92 took HRT. Endometrial thickness (ET) and pregnancy outcome were measured in both groups.Results: Mean infertility duration (p=0.328), number of embryos (p=0.649), FSH (p=0.390), LH (p=0.051) and LH/FSH ratio (p=0.287) as well as type of infertility (primary or secondary) (p=0.295), causes of infertility (p=0.750) and pattern of menstruation (p=0.676) were not significantly different in the two groups. Mean ET in the TMX and HRT groups were 8.72±1.45mm and 9.00±1.69mm, respectively (p=0.423). There was no statistically significant difference between chemical pregnancy (p=0.663), clinical pregnancy (p=0.994) and ongoing pregnancy (p≥0.999) in the TMX and HRT groups.Conclusions: Treatment with tamoxifen can be as effective as GnRH agonist for endometrial preparation in FET.

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“…For the period 2013-2014 (Table 3), we reviewed 17 reports (Asadi et al, 2014;Aydin et al, 2013;Blockeel et al, 2014;Farquhar et al, 2013;Goldman et al, 2014;Kamath et al, 2013;Karamahmutoglu et al, 2014;Kaser et al, 2014;Oruç et al, 2014;Pourmatroud et al, 2013;Rashidi et al, 2013;Riad and Hak, 2014;Romero Nieto et al, 2014;Scholten et al, 2013;Seckin et al, 2014;Van Rumste et al, 2014;Weiss et al, 2015) totalling 4968 cycles. In seven reports, no mention was made of complications (Asadi et al, 2014;Aydin et al, 2013;Blockeel et al, 2014;Kamath et al, 2013;Karamahmutoglu et al, 2014;Oruç et al, 2014;Riad and Hak, 2014).…”

Section: Review Of Prospective Studies Published Between 2013 and 2014mentioning

confidence: 99%

Risk of pelvic inflammatory disease after intrauterine insemination: a systematic review

Matorras

Rubio

Iglesias

et al. 2018

Reproductive BioMedicine Online

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A new look at tamoxifen: co-administration with letrozole in intrauterine insemination cycles

Abstract: In addition to the efficacy of tamoxifen in co-administration with clomiphene citrate, it has promising effects with letrozole in induction of ovulation cycles with or without IUI.

Cited by 6 publications

References 19 publications

The Effect of Tamoxifen on Thin Endometrium in Patients Undergoing Frozen—Thawed Embryo Transfer

The Effect of Tamoxifen on Thin Endometrium in Patients Undergoing Frozen—Thawed Embryo Transfer

Comparison of tamoxifen and hormone replacement cycle (HRT) in frozen embryo transfer. A randomized controlled trial

Risk of pelvic inflammatory disease after intrauterine insemination: a systematic review

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