A new lignan glycoside from the rhizomes of<i>Imperata cylindrica</i>

Lee, Dae-Young; Han, K. L.; Song, Myoung‐Chong; Lee, Do-Gyeong; Rho, Yeong-Deok; Baek, Nam‐In

doi:10.1080/10286020701783419

Cited by 11 publications

(9 citation statements)

References 9 publications

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“…The contents of the four compounds were evaluated and revealed to be in the following order of abundance: isoeugenin (approximately 0.268 mg/g dry weight) > ferulic acid (approximately 0.042 mg/g) > p-coumaric acid (approximately 0.182 mg/g) > caffeic acid (approximately 0.020 mg/g). These four compounds were distributed mainly in the CHCl 3 and EtOAc fractions as shown in Table 2. However, these substances are present in minute quantities in the hexane and BuOH fractions and isoeugenin was not detected in the EtOAc fraction.…”

Section: Isolation and Characterization Of Compoundsmentioning

confidence: 99%

“…All of these have two CH 3 groups, but some of them do not have a OCH 3 . The HR-ESI-MS showed that compound 1 exhibited an m/z of 206.0579 corresponding to a [C 11 H 10 O 4 ] + molecular ion.…”

Section: Isolation and Characterization Of Compoundsmentioning

confidence: 99%

“…The major phytochemical constituents identified in I. cylindrica are phenylpropanoids [2], lignan glycosides [3], biphenyl ethers [4], sesquiterpenoids [5], phenolic compounds [6], lignans [5], and megastigmatrienone [7].…”

Section: Introductionmentioning

confidence: 99%

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Isoeugenin, a Novel Nitric Oxide Synthase Inhibitor Isolated from the Rhizomes of Imperata cylindrica

Nugroho

Song

et al. 2015

Molecules

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Phytochemical studies on the constituents of the rhizomes of Imperata cylindrica (Gramineae) were performed using high-performance liquid chromatography (HPLC). We also aimed to search for any biologically active substance capable of inhibiting nitric oxide (NO) formation in lipopolysaccharide (LPS)-activated macrophage 264.7 cells, by testing four compounds isolated from this plant. Four compounds, including a new chromone, isoeugenin, along with ferulic acid, p-coumaric acid, and caffeic acid were isolated and identified by NMR spectroscopy. The structure of isoeugenin was determined as 7-hydroxy-5-methoxy-2-methylchromone by the 2D-NMR technique. Among the four compounds, isoeugenin has the lowest IC 50 value on the inhibition of NO production in LPS-activated macrophage RAW264.7 cells (IC 50 , 9.33 µg/mL). In addition, isoeugenin significantly suppressed the LPS-induced expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and proinflammatory cytokines mRNA levels. Taken together, these results suggest that the anti-inflammatory activity of isoeugenin is associated with the down-regulation of iNOS, COX-2, and pro-inflammatory cytokines in RAW264.7 cells. Accordingly, our results suggest that the new chromone isoegenin should be considered a potential treatment for inflammatory disease.

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Section: Isolation and Characterization Of Compoundsmentioning

confidence: 99%

Section: Isolation and Characterization Of Compoundsmentioning

confidence: 99%

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Isoeugenin, a Novel Nitric Oxide Synthase Inhibitor Isolated from the Rhizomes of Imperata cylindrica

Nugroho

Song

et al. 2015

Molecules

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“…Efek antioksidan, anti mikroba, anti agregasi trombosit dan antiinflamasi akar alang-alang membantu meredakan keluhan nyeri kepala yang disebabkan oleh radang, infeksi maupun kondisi kekentalan darah. 9,17,20,42 Efek diuretiknya untuk sakit kepala karena peningkatan tekanan intrakranial seperti pada hipertensi dan odema cerebri, sedangkan efek neuroprotektif untuk kondisi hipertensi dan kerusakan otak. 15,46 Uji klinik terhadap ramuan jamu untuk BSK yang terdiri dari herba tempuyung, keji beling, kumis kucing, akar alang-alang, umbi temulawak, kunyit dan herba meniran telah dilakukan.…”

Section: Pembahasanunclassified

“…Kemampuan akar alang-alang tersebut ditentukan oleh aktivitas antioksidan, antiinflamasi dan diuretik yang dimilikinya. 9,20,46 Sebagai ramuan penyusun ISK, akar alang-alang biasanya diberikan bersamaan dengan temulawak, kunyit dan tempuyung. ISK terbanyak disebabkan oleh bakteri E.colli dengan tanda dan gejala klinik antara lain nyeri saat kencing, kencing darah, sering kencing, nyeri perut bawah dan demam.…”

Section: Pembahasanunclassified

Studi Literatur untuk Memperoleh Dasar Ilmiah Penggunaan Akar Alang-alang sebagai Ramuan Jamu untuk Penyembuhan Beberapa Penyakit di Rumah Riset Jamu Hortus Medicus

Zulkarnain

Wijayanti

Fitriani

et al. 2020

mpk

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Alang-alang or Imperata grass known by people the Indonesian has many health benefits . RRJ Hortus Medicus as a service-based research clinic uses alang-alang roots in hebal formula to treat hypertension, osteoarthritis, headache, urinary tract stones, urinary tract infection, stomatitis and prostate enlargement. In addition to having empirical usage data, all plants used in RRJ must have scientific data. This study is a literature study with the aimof obtaining the scientific basis for the use of alang-alang roots. Search articles from scientific journals through google scholar, google and pubmed search engines with the keywords alang-alang or Imperata cylindrica and assistive words in accordance with the claims of use. The selected article is a complete of the results of experiments and surveys that are in accordance with topics both in Indonesian and English until 2018. The results of the study show that Imperata roots contain phenols and tannins which are antioxidants, isogeunin compound as anti-inflammatory, lignans as vasodilation, sinensitin, eupatorin, tetra-O-methylscutellar-ein 3 '-hydroxy-5,6,7 , 4 '-tetramethoxyflavone as a diuretic, imperanene as platelet antiaggregation and 5-hydroxy-2- (2-phenylethyl) chromone and 5-hydroxy-2- [2- (2- hydroxyphenyl) ethyl chromone as neuroprotective . Imperata is also shown to have antimicrobial and anti-neoplasmic activity. The various active compounds and activities above, support the use of Imperata in the Hortus Medicus RRJ. Abstrak Tanaman alang-alang sejak dulu telah dikenal oleh masyarakat Indonesia memiliki banyak manfaat bagi kesehatan. Rumah Riset Jamu (RRJ) Hortus Medicus sebagai klinik penelitian berbasis pelayanan menggunakan akar alang-alang dalam ramuan jamu untuk mengobati hipertensi, osteoartritis, nyeri kepala, batu saluran kemih, infeksi saluran kemih, panas dalam, dan pembesaran prostat. Di samping memiliki data penggunaan empiris, semua tanaman yang digunakan di RRJ harus memiliki data ilmiah. Kajian ini merupakan studi literatur dengan tujuan memperoleh dasar ilmiah penggunaan akar alang-alang di RRJ. Penelusuran artikel dari jurnal ilmiah melalui mesin pencari google scholar, google, dan pubmed dengan kata kunci alang-alang atau Imperata cylindrica dan kata bantu sesuai dengan klaim penggunaannya. Artikel yang dipilih adalah artikel lengkap hasil eksperimen maupun survei yang sesuai dengan topik baik berbahasa Indonesia maupun Inggris sampai tahun 2018. Hasil studi menunjukkan akar alang-alang mengandung fenol dan tanin yang bersifat sebagai antioksidan; senyawa isogeunin sebagai anti inflamasi; lignan sebagai vasodilatasi, sinensitin, eupatorin, tetra-O-methylscutellar-ein 3’-hydroxy-5,6,7, 4‘-tetramethoxyflavone sebagai diuretik; imperanene sebagai antiagregasi trombosit dan serta 5-hydroxy-2-(2-phenylethyl) chromone dan 5-hydroxy-2-[2-(2- hydroxyphenyl) ethyl chromone sebagai neuroprotektif. Alang-alang juga terbukti memiliki aktivitas antimikroba dan anti neoplasma. Berbagai kandungan senyawa aktif dan aktivitas di atas, mendukung penggunaan alang-alang di RRJ Hortus Medicus.

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Four new compounds from Imperata cylindrica

Zhang

Yang

et al. 2013

J Nat Med

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Four new compounds, impecylone (1), deacetylimpecyloside (2), seguinoside K 4-methylether (3) and impecylenolide (4), were isolated from Imperata cylindrica along with two known compounds, impecyloside (5) and seguinoside K (6). Their structures were elucidated mainly by spectroscopic analyses including 1D- and 2D-NMR techniques, and the absolute configuration of 1 was confirmed by X-ray diffraction analysis. In calcium assay, the result indicated that compounds 1, 2, 4 and 5 cannot obviously inhibit the calcium peak value compared with the negative control, and suggested that the four compounds could not have anti-inflammatory activity.

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A new lignan glycoside from the rhizomes ofImperata cylindrica

Cited by 11 publications

References 9 publications

Isoeugenin, a Novel Nitric Oxide Synthase Inhibitor Isolated from the Rhizomes of Imperata cylindrica

Isoeugenin, a Novel Nitric Oxide Synthase Inhibitor Isolated from the Rhizomes of Imperata cylindrica

Studi Literatur untuk Memperoleh Dasar Ilmiah Penggunaan Akar Alang-alang sebagai Ramuan Jamu untuk Penyembuhan Beberapa Penyakit di Rumah Riset Jamu Hortus Medicus

Four new compounds from Imperata cylindrica

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