A new lavandulyl flavonoid from Sorphora flavescens Ait

Flavonoids and their glycosides, including anthocyanins

“…352 On bioassay-guided fractionation the latter yielded the b-hydroxychalcones, 3 0 -prenyllicodione 2 0 -methyl ether (441) and 3 0 ,3-diprenyllicodione 2 0 -methyl ether (442), which showed moderate inhibitory activity. 352 Further work by Miyase's group on the flavonoids of Lespedeza cyrtobotrya (Leguminosae) afforded lespecyrtins B 1 -B 3 (443)(444)(445), which were effective inhibitors of melanin synthesis in normal human epidermal melanocytes. 353 Both lespecyrtin B 1 (443; IC 50 ¼ 1.3 mM) and B 2 (444; IC 50 ¼ 1.0 mM) showed more potent activity than the skin-whitening agent, hydroquinone, which was used as a positive control (IC 50 ¼ 2.2 mM).…”

“…397 Fractionation of extracts of the whole plant of Eriosema glomeratum (Leguminosae) yielded erioschalcones A (509) and B (510), which showed antimicrobial activity against a panel of test organisms. 398 Lespecyrtin C 1 ( 511) is a dihydrofurano-functionalised derivative of davidigenin, and one of several new flavonoid constituents (see also [443][444][445]715) isolated from root extracts of Lespedeza cyrtobotrya (Leguminosae) by Miyase's group at the University of Shizuoka, Japan. 353 The latter also reported seven new prenylated a-hydroxydihydrochalcones from root extracts of Lespedeza floribunda (Leguminosae) as lespeflorins C 1 -C 7 (512)(513)(514)(515)(516)(517)(518), together with flavanones (604-607) and dihydroflavonols (716-718).…”

“…444 Three groups reported on prenylated flavanones (610-614) found as minor constituents in the roots of Sophora flavescens (Leguminosae). [445][446][447] Interest in this well-studied species is due mainly to its use in traditional Chinese medicine, where the roots or rhizomes are referred to as 'Ku Shen'. 445 Characteristically, several of the flavanones obtained are substituted by lavandulyl groups (613), 447 or modifications thereof (610, 612, 614).…”

“…[445][446][447] Interest in this well-studied species is due mainly to its use in traditional Chinese medicine, where the roots or rhizomes are referred to as 'Ku Shen'. 445 Characteristically, several of the flavanones obtained are substituted by lavandulyl groups (613), 447 or modifications thereof (610, 612, 614). 445,447 Tonkinochromanes D-K (615-622) are 5-deoxyflavanones characterised by prenyl substitution in both A-and B-rings, including several cyclised forms.…”

Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages

“…Thus, the structure of the new compound 3 (alopecurone O) was assigned as shown. Additionally, the previously reported compounds were confirmed to be alopecurone B (4), 13 alopecurone C (5), 13 alopecurone F (6), 13 alopecurone G (7), 13 kurarinone (8), 21 sophoraflavanone G (9), 22 5,4 0 -Di-O-methylsophoraflavanone G (10), 23 2 0 -O-methylsophoraflavanone K (11), 24 lehmannin (12), 25 leachianone A (13), 26 2 0 -demethoxyleachianone B (14), 27 8-prenylnaringenin (15), 28 4 0 -O-methyl-8-prenylnaringenin (16), 29 isobavachin (17), 29 ammothamnidin (18), 30 pallidol (19), 31 leachianol D (20), 32 leachianol E (21), 32 trifolirhizin (22), 30 cudraxanthone D (23), 33 and 6-(2,2-dimethyl-4-chromanone)acrylic acid (24). 34 All isolates were evaluated to assess their ability to inhibit LPSinduced NO production in RAW 264.7 cells with aminoguanidine as the positive control.…”