A new lanostane-type triterpene and sesquiterpene lactones from<i>Vernonia leopoldii</i>and their<i>in vitro</i>cytotoxicity

Marzouk, Amani M.; Elhalim, Osama B Abd

doi:10.1080/14786419.2015.1062004

Cited by 12 publications

(4 citation statements)

References 27 publications

(28 reference statements)

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“…In addition, it is widely used for the treatment of cancer ( Tuasha et al, 2022 ). Recently, a new triterpene isolated from the aerial part of this plant has shown an appreciable cytotoxicity against several cancerous cell lines ( Marzouk and Abd Elhalim, 2016 ). Laggera tomentosa (A.Rich.)…”

Section: Resultsmentioning

confidence: 99%

Ethnobotanical study of endemic and non-endemic medicinal plants used by indigenous people in environs of Gullele botanical garden Addis Ababa, central Ethiopia: A major focus on Asteraceae family

et al. 2022

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Gullele Botanical Garden (GBG) in Addis Ababa, Ethiopia is a joint venture of Addis Ababa government and the university. The garden has been built mainly to conserve the endemic plants and to advance the research on the endemic and non-endemic plants collected from different part of Ethiopia. Many traditional healers from the environs of GBG and different subcities of Addis Ababa depend on the garden for their practice of traditional medicine but there is no systematic documentation of the traditional medicinal knowledge of these healers. The main objective of the present study is to comprehensively document the ethnobotanical and ethnomedicinal information from the traditional healers of different ethnic and cultural groups depending on GBG and to create a database of the endemic plants used by these healers. The ethnobotanical and ethnomedicinal data obtained from 60 traditional healers have been analyzed both qualitatively and quantitatively. A total of 81 medicinal plants belonging to 47 families have been identified. Majority of the plants used belonged to Asteraceae (12) family. The most frequently used plant form and plant parts are herbs and leaves. The major method adopted by the healers for preparation and administration of traditional medicine is crushing and topical, respectively. Skin and general diseases are the most important ailments treated by the healers. The three most cited plants used to treat diseases are Echinops kebericho Mesfin (60), Hagenia abyssinica (Bruce) J.F.Gmel (60) and Laggera tomentosa (A.Rich.) Sch.Bip. ex Oliv. & Hiern (58). The present study is the first systematic, qualitative, and quantitative ethnobotanical analysis and documentation done on the use of the medicinal plants from GBG for traditional medicine. In addition, our study reveals that E. kebericho is endemic and endangered plant and is highly used in traditional medicine. Therefore, GBG authorities should take steps for the propagation and restoration of this plant. Further it is suggested that the pharmacological properties of the roots and leaves of E. kebericho should be compared to find the possibility of use of leaves in place of roots for the preparation of traditional medicine which would help in conserving this endemic plant of Ethiopia.

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Section: Resultsmentioning

confidence: 99%

Ethnobotanical study of endemic and non-endemic medicinal plants used by indigenous people in environs of Gullele botanical garden Addis Ababa, central Ethiopia: A major focus on Asteraceae family

et al. 2022

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“…Marzouk and Abd Elhalim [72], using NMR technique, found in the extract of V. leopoldii aerial parts compounds previously not reported in the literature, characterized as sesquiterpene lactones, triterpene tetracyclic and apigenin-7-O-glucide and luteolin-7-O-glucide. According to the authors, chemical and pharmacological investigations have shown that the sesquiterpene lactones found in plants of the genus Vernonia present antitumor activities, and some sesquiterpene lactones may exhibit strong cytotoxicity against tumor cell lines.…”

Section: Explorative Analyses: Correlations Between Phytochemicals Antioxidant Activity and Anticancer Effectsmentioning

confidence: 94%

Phytochemical Screening, Antioxidant, Anti-Cytotoxic and Anticancer Effects of Galinsoga Parviflora and Vernonia Polyanthes (Asteraceae) Extracts

Feleti

Aleluia

Gervásio

et al. 2020

Int. J. Res. Granthaalayah

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The study was designed to investigate the chemical composition and the biological effects of G. parviflora and V. polyanthes ethanolic extracts in vitro. Total content of phenols, flavonoids and tannins was quantified by spectrophotometry; chemical characterization was permed by mass spectrometry (ESI (-) FT-ICR MS and APCI (+) FT-ICR MS analysis). Antioxidant activities were determined by FRAP and Fe2+ chelating methods. Extracts cytotoxicity was evaluated in human lymphocytes, sarcoma-180 (S-180) and human gastric adenocarcinoma (AGS) cells, by MTT assay. V. polyanthes presented higher total content of tannins and G. parviflora presented higher amount of phenols and flavonoids. Chemical characterization showed the presence of flavonoids, phenolic acids and sesquiterpene lactones in V. polyanthes extract, and steroids, phenolic acids and fatty acids (Poly Unsaturated Fatty Acids - PUFA) in G. parviflora extract. V. polyanthes extract stood out in the Fe2+ chelation test. G. parviflora extract did not present outstanding antioxidant results in the tested protocols. Both species showed a tendency to promote cytotoxicity in human lymphocyte cells. Regarding the antiproliferative effect, both species were able to reduce S-180 cell viability and G. parviflora extract showed high antiproliferative potential in the assay with AGS cells. These findings reinforce the medicinal use of these plants, as well as suggest their potential use for the development of new drugs and for the treatment of cancers.

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“…Among species of Vernonia, antitumor properties have been described Vernonia amygdalina [5,11,47,48,49], Vernonia bockiana [50], Vernonia cinerea [51,52,53], Vernonia condensate [54], Vernonia divaricata [43], Vernonia extensa [44], Vernonia fimbrillifera [55], Vernonia glaberrima [56,57], Vernonia kotschyana [58], Vernonia leopoldii [59], Vernonia mespilifolia [60], Vernonia pachyclada [61], Vernonia paniculata [62], Vernonia patula [63], Vernonia polyanthes [64], and Vernonia scorpioides [65,66,67], Vernonia zeylanica [42,68].…”

Section: Genus Antitumor Activitymentioning

confidence: 99%

Genus Vernonia (Asteraceae): A Promising Source of Antitumor Agents with Pharmacological Potentials

Gonzatto

Araújo²,

Albuquerque³

2022

AIR

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Antitumor research leads to the development of new molecules that act specifically in tumor cells by blocking or inhibiting their molecular targets. New therapeutic approaches for the screening of bioactive compounds present in medicinal plants have received increasing attention due to their chemopreventive and chemotherapeutic properties. In ethnomedicine, plants of the genus Vernonia (Asteraceae) are widely used and some have shown several and interesting biological activities, including anticancer. This present study aimed to document experimental evidence supporting the claimed ethnomedical uses of Vernonia species for the treatment of various types of cancer and also to confirm the anticancer potential of these plants. The compounds isolated from aqueous and alcoholic extracts, as well as fractions from different parts of Vernonia plants have acted as potential anticancer agents that inhibited the proliferation of various types of human cancer cell lines, including cervical cancer cells, melanoma cells, promyelocytic leucemia cells, breast adenocarcinoma cells, ovarian cancer, liver cancer cell, and human lung cancer cells. Studies have correlated the antitumor activity of Vernonia plants by inducing apoptosis and modulating mitochondrial signaling pathways controlled by NF-κB, Bcl-2 and p53, as well as inducing DNA damage and arresting the cell cycle at the S-phase checkpoint by oxidative stress. In conclusion, Vernonia species act as a promising source for drug development. However, further studies are needed to explore the exact mechanism of action, pharmacokinetics, chronic toxicological studies, safe dose consumption, and possible interactions with other herbs.

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A new lanostane-type triterpene and sesquiterpene lactones fromVernonia leopoldiiand theirin vitrocytotoxicity

Cited by 12 publications

References 27 publications

Ethnobotanical study of endemic and non-endemic medicinal plants used by indigenous people in environs of Gullele botanical garden Addis Ababa, central Ethiopia: A major focus on Asteraceae family

Ethnobotanical study of endemic and non-endemic medicinal plants used by indigenous people in environs of Gullele botanical garden Addis Ababa, central Ethiopia: A major focus on Asteraceae family

Phytochemical Screening, Antioxidant, Anti-Cytotoxic and Anticancer Effects of Galinsoga Parviflora and Vernonia Polyanthes (Asteraceae) Extracts

Genus Vernonia (Asteraceae): A Promising Source of Antitumor Agents with Pharmacological Potentials

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