A new kaempferol trioside from Solidago altissima L.

Jin, Haili; Tanaka, Takashi; Kouno, Isao; Ishimaru, Kanji

doi:10.1007/s11418-007-0139-6

Cited by 9 publications

(7 citation statements)

References 15 publications

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“…As an example, alprostadil acts as a PGE1 agonist and affects the adenylate cyclase (AC)-cAMP pathway [28,29]. Besides this, inhibition of the vasoconstriction is another possible strategy that could be pursued opportunely interacting with endothelin [30], angiotensin [31], and adrenergic receptors [32].…”

Section: Alternative Targetsmentioning

confidence: 99%

The Old Made New: Natural Compounds against Erectile Dysfunction

Pavan

Mucignat‐Caretta

Redaelli

et al. 2015

Archiv der Pharmazie

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The interest toward sex-related diseases keeps growing through the years. In this review, we focus our attention on erectile dysfunction (ED), a condition that caught much attention especially after the introduction on the market of phosphodiesterase 5 inhibitors such as the well-known sildenafil. Here, we briefly describe both the etiology of ED and the available treatments, examining then extensively some natural derivatives that, coming from traditional medicine, could represent promising starting points for the development of alternative remedies. In fact, herbal remedies from several parts of the world have been traditionally known for long, and were recently reconsidered and are now being studied to demonstrate their eventual potential in the treatment of ED. Among the various examples reported in the literature and reviewed here, plants and extracts containing polyphenols—especially a class of compounds called kraussianones—appear to be particularly effective and promising against ED.

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Section: Alternative Targetsmentioning

confidence: 99%

The Old Made New: Natural Compounds against Erectile Dysfunction

Pavan

Mucignat‐Caretta

Redaelli

et al. 2015

Archiv der Pharmazie

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“…The following instruments were used to obtain physical data: specific rotations, a Horiba SEPA-300 digital polarimeter (l=5 cm); IR spectra, a Shimadzu FTIR-8100 spectrometer; CD spectra, a JASCO J-720WI spectrometer; EI-MS and HR-EI-MS, JEOL JMS-GCMATE mass spectrometer; FAB-MS and HR-FAB-MS, a JEOL JMS-SX 102A mass spectrometer; 1 H-NMR spectra, JEOL JNM-ECA600 (600 MHz) spectrometers; Table 1 (17) 5.6 3-O-trans-Coumaroyl-d-quinic acid (18) 11.5 3-O-cis-Coumaroyl-d-quinic acid (19) 55.2 Taxiphyllin (22) 54.1 Umbelliferone glucoside (23) 68.6 4-O-trans-Caffeoyl-d-quinic acid (25) 11.8 3,4-Di-O-trans-caffeoyl-d-quinic acid (26) 0.34 3,5-Di-O-trans-caffeoyl-d-quinic acid (27) 0.31 4,5-Di-O-trans-caffeoyl-d-quinic acid (28) 0.29 Chlorogenic acid methyl ester (21) 44) 2.4 Chlorogenic acid (20) + : m/z 473.1060). Acid Hydrolysis of 1-6 Compounds 1-6 (1.0 mg each) were dissolved in 5% aqueous H 2 SO 4 -1,4-dioxane (1 : 1, v/v, 1.0 mL), and each solution was heated at 80°C for 1 h. After cooling, each reaction mixture was neutralized with Amberlite IRA-400 (OH − form) and filtrated, and the solution was partitioned with EtOAc to give two layers.…”

Section: Experimental General Experimental Proceduresmentioning

confidence: 99%

Medicinal Flowers. XXXX.1) Structures of Dihydroisocoumarin Glycosides and Inhibitory Effects on Aldose Reducatase from the Flowers of Hydrangea macrophylla var. thunbergii

Liu

Nakamura

Zhen

et al. 2013

CHEMICAL & PHARMACEUTICAL BULLETIN

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Key words florahydroside; Hydrangea macrophylla var. thunbergii; medicinal flower; dihydroisocoumarin glycoside; aldose reductase; acylated quinic acid analogThe Saxifragaceae plant, Hydrangea (H.) macrophylla Seringe var. thunbergii Makino, is native to Japan. The processed leaves of this plant (Hydrangea Dulcis Folium) are currently used as a natural medicine for an oral refrigerant and as a sweetener for diabetic patients. In addition, these preparations are listed in the Japanese Pharmacopoeia. Previously, we reported the isolation and structure determination of many chemical constituents with anti-diabetic, anti-allergic, and anti-bacterial activities from the processed leaves and the dried leaves of this plant.2-6) However, a full chemical analysis of the flowers from this plant has not yet been performed. In the course of our chemical and pharmacological studies on Hydrangea plants [2][3][4][5][6][7][8] and medicinal flowers, [9][10][11][12][13][14] we recently reported the isolation and structure elucidation of secoiridoid glycosides named hydrangeamines A and B with a pyridine ring from the flowers of H. macrophylla var. thunbergii cultivated in Nagano prefecture, Japan.15) As a continuing study, six dihydroisocoumarin glycosides, florahydrosides I (1) and II (2), thunberginol (5), and thunberginol D 3′-O-β-dglucopyranoside (6), were isolated from the flowers of H. macrophylla var. thunbergii together with 20 known compounds including five acylated quinic acid analogs. Furthermore, the inhibitory effects of the isolated compounds and its related compounds on aldose reductase were investigated. This paper deals with the structure elucidation of the new dihydroisocoumarin glycosides (1-6) and the inhibitory effects of the constituents and their related compounds, acylated quinic acid analogs, on aldose reductase.A methanol (MeOH) extract (32.2% from the flowers of H. macrophylla var. thunbergii cultivated in Nagano province) was partitioned between EtOAc-H 2 O (1 : 1) to furnish an EtOAc-soluble fraction (8.8%) and an aqueous layer. The aqueous layer was further extracted with 1-butanol

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“…The available information is the inhibitory effect of the n -hexane extracts of the underground parts of S. altissima on the growth of Lactuca sativa L. [ 95 ]. However, phytochemical investigations suggest that S. altissima contains polyacetylenes [ 96 , 97 ], monoterpene and sesquiterpenes [ 98 ], diterpenes [ 95 , 98 , 99 , 100 , 101 , 102 ], triterpenes [ 103 , 104 ], flavonoid glycosides [ 105 , 106 ] and polyphenols [ 107 ]. Some of them may act as allelopathic agents of the species.…”

Section: Allelopathy Of S Altissimamentioning

confidence: 99%

Allelopathy and Allelochemicals of Solidago canadensis L. and S. altissima L. for Their Naturalization

Kato‐Noguchi

Kato²

2022

Plants

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Solidago canadensis L. and Solidago altissima L. are native to North America and have naturalized many other continents including Europa and Asia. Their species is an aggressive colonizer and forms thick monospecific stands. The evidence of the allelopathy for S. canadensis and S. altissima has accumulated in the literature since the late 20th century. The root exudates, extracts, essential oil and rhizosphere soil of S. canadensis suppressed the germination, growth and the arbuscular mycorrhizal colonization of several plants, including native plant species. Allelochemicals such as fatty acids, terpenes, flavonoids, polyphenols and their related compounds were identified in the extracts and essential oil of S. canadensis. The concentrations of total phenolics, total flavonoids and total saponins in the rhizosphere soil of S. canadensis obtained from the invasive ranges were greater than those from the native ranges. Allelochemicals such as terpenes, flavonoids, polyacetylene and phenols were also identified in the extracts, essential oil and the rhizosphere soil in S. altissima. Among the identified allelochemicals of S. altissima, the cis-dehydromatricaria ester may be involved in the allelopathy considering its growth inhibitory activity and its concentration in the rhizosphere soil. Therefore, the allelopathy of S. canadensis and S. altissima may support their invasiveness, naturalization and formation of thick monospecific stands. This is the first review article focusing on the allelopathy of both of S. canadensis and S. altissima.

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A new kaempferol trioside from Solidago altissima L.

Cited by 9 publications

References 15 publications

The Old Made New: Natural Compounds against Erectile Dysfunction

The Old Made New: Natural Compounds against Erectile Dysfunction

Medicinal Flowers. XXXX.<sup>1)</sup> Structures of Dihydroisocoumarin Glycosides and Inhibitory Effects on Aldose Reducatase from the Flowers of <i>Hydrangea macrophylla</i> var. <i>thunbergii</i>

Allelopathy and Allelochemicals of Solidago canadensis L. and S. altissima L. for Their Naturalization

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