A new insight on Al-maltolate-treated aged rabbit as Alzheimer's animal model

Bharathi,; Shamasundar, N M; Rao, T.S. Sathyanarayana; Naidu, M. Prasad; Ravid, Rivka; Rao, K. S.

doi:10.1016/j.brainresrev.2006.04.003

Cited by 80 publications

(33 citation statements)

References 144 publications

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“…This could be due to the reduced axonal mitochondria turnover, disruption of Golgi and reduction of synaptic vesicles induced by Al exposure which results in release of oxidative products like MDA and carbonyls within the neurons (Bharathi et al, 2006), this is already supported by the present study.…”

Section: Oxidative Stress Markerssupporting

confidence: 78%

The Protective Role of Omega-3 and Melatonin Against AlCl3 Induced some Biochemical Changes in Albino Rats

Mohammed¹,

Ali²

2017

Cihan Univ.-Erbil Sci. J.

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The aim of the present study was to demonstrate the protective role of omega-3, melatonin and their combination against AlCl 3 induced some biochemical changes especially (OS, lipid peroxidation and AD) markers in serum of experimental rats. Forty adult female rats were used in this present study. They were divided randomly into five groups, each group with eight rats. G1: considered as a control group. G2: (1000mg/L drinking water) AlCl 3 . G3: (1000mg/L drinking water) AlCl 3 + omega-3 oil (4000mg/kg diet). G4: (1000mg/L drinking water) AlCl 3 + melatonin (50mg/kg diet). G5: (1000mg/L drinking water) AlCl 3 + omega-3 oil (4000mg/kg diet) + melatonin (50mg/kg diet). All the above groups left for 40 days. Administration of AlCl 3 (1000mg/L) caused decreased rats brain weight , while there were no statistical changes in body weight, water intake and diet consumption among the studied groups. The results of biochemical study revealed that AlCl 3 decreased SOD level while MDA and Aβ (1-42) peptide level increased. On the other hand, melatonin, omega-3 and their combination effectively increased SOD level except for omega-3 treated group in which no such effect detected on SOD level, while not affected on MDA level but decreased Aβ (1-42) peptide level. As well as CK activity increased in observed in AlCl 3 group while treatment with melatonin, omega-3 and their combination ameliorate this effect. Additionally, AlCl 3 unexpectedly decreased urea concentration, only combination of omega-3 and melatonin normalized urea concentration. Sub-acute dose of AlCl 3 did not cause any significant effect on serum ALP, AST, ALT creatinine, LDH and glucose levels.In conclusion AlCl 3 caused many biochemical changes in of albino rats, while omega-3, melatonin either alone or together showed a protective role against AlCl 3 toxicity. This protection could be through the antioxidant and anti-amyloidal role of omega-3 and melatonin.

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Section: Oxidative Stress Markerssupporting

confidence: 78%

The Protective Role of Omega-3 and Melatonin Against AlCl3 Induced some Biochemical Changes in Albino Rats

Mohammed¹,

Ali²

2017

Cihan Univ.-Erbil Sci. J.

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“…As a result, activated SOD enzyme readily converts the superoxide anion into hydrogen peroxide (H 2 O 2 ). However, deactivated catalase could not convert the H 2 O 2 into water and oxygen that further leads to generation of hydroxyl radical ion [44]. These factors contribute towards oxidative stress that ultimately leads to neurodegeneration.…”

Section: Discussionmentioning

confidence: 99%

Hesperidin and Silibinin Ameliorate Aluminum-Induced Neurotoxicity: Modulation of Antioxidants and Inflammatory Cytokines Level in Mice Hippocampus

Jangra

Kasbe

Pandey

et al. 2015

Biol Trace Elem Res

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Mounting evidence suggests that long-term aluminum exposure results in severe toxic effects, including neurobehavioral and neurochemical anomalies. The present study was performed to examine the neuroprotective potential of hesperidin and silibinin against aluminum chloride (AlCl3)-induced neurotoxicity in mice. AlCl3 (100 mg/kg/day) was injected daily through oral gavage for 42 days. Concomitantly, hesperidin (50 and 100 mg/kg/day, p.o.) and silibinin (100 and 200 mg/kg/day, p.o.) was administered for 42 days in different groups. The extent of cognitive impairment was assessed by Morris water maze and novel object recognition test on the 43rd day. Neurotoxicity was assessed by measuring oxido-nitrosative stress and proinflammatory cytokines in the hippocampus of mice. Six weeks treatment with AlCl3 caused cognitive impairment as indicated by an increase in the retention latency time and reduction in the percentage of recognition index. AlCl3-treated group showed oxido-nitrosative stress as indicated by increase in the level of lipid peroxidation, nitrite and depleted reduced glutathione, catalase activity in the hippocampus. Moreover, the chronic AlCl3 administration raised the proinflammatory cytokines (interleukin-1β and tumor necrosis factor-α) level and increased acetylcholinesterase activity and reduced the BDNF content in the hippocampus of AlCl3-treated animals. However, chronic treatment with hesperidin and silibinin at higher doses significantly ameliorated the AlCl3-induced cognitive impairment and hippocampal biochemical anomalies. The present study clearly indicated that hesperidin and silibinin exert neuroprotective effects against AlCl3-induced cognitive impairment and neurochemical changes. Amelioration of cognitive impairment may be attributed to the impediment of oxido-nitrosative stress and inflammation in the hippocampus.

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“…Previously, Al has been widely used as a cell death-inducing agent to mimic cell degeneration pathology, especially in AD [8,9,26]. Moreover, it has been suggested that Al-induced apoptotic changes, oxidative stress, and axonal transport disruption are linked in a way that promotes neurodegeneration [27][28][29]. If similar regulatory mechanisms are indeed recapitulated, Al-induced cellular toxicity might serve as a useful model to understand the molecular underpinnings that underlie neuronal cell death during neurodegeneration.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic potential of BAK gene silencing in aluminum induced neural cell degeneration

Zhang

Qiao

Shi

et al. 2009

Journal of Inorganic Biochemistry

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A new insight on Al-maltolate-treated aged rabbit as Alzheimer's animal model

Cited by 80 publications

References 144 publications

The Protective Role of Omega-3 and Melatonin Against AlCl3 Induced some Biochemical Changes in Albino Rats

The Protective Role of Omega-3 and Melatonin Against AlCl3 Induced some Biochemical Changes in Albino Rats

Hesperidin and Silibinin Ameliorate Aluminum-Induced Neurotoxicity: Modulation of Antioxidants and Inflammatory Cytokines Level in Mice Hippocampus

Therapeutic potential of BAK gene silencing in aluminum induced neural cell degeneration

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