A New Index of Abdominal Obesity which Effectively Predicts Risk of Colon Tumor Development in Female Japanese

Kaneko, Rena; Nakazaki, Natsuko; Tagawa, Teppei; Ohishi, Chitose; Kusayanagi, Satoshi; Kim, Miniru; Baba, Toshiyuki; Ogawa, Masazumi; Sato, Yuzuru

doi:10.7314/apjcp.2014.15.2.1005

Cited by 13 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since Asians tend to show higher risks for colorectal cancer than other races according to BMI increase27, racial differences cannot be disregarded. A study on Japanese subjects also showed that the association between WHtR and colorectal cancer was more significant in women than in men28, which was similar to the finding in the present study and also serves as an evidence that a racial difference exists. Third, compared to previous studies that used the obesity criteria for Westerners, the present study used more stringent criteria for obesity, which may have led to different results being obtained.…”

Section: Discussionsupporting

confidence: 90%

Obesity Markers as Predictors for Colorectal Neoplasia

Kwon

Youn

et al. 2017

JOMES

View full text Add to dashboard Cite

Background The goal of this study was to determine the relations between the risk of colorectal neoplasia and obesity markers: body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR). Methods The subjects who underwent screening colonoscopies at a Kyungpook National University Hospital in Daegu from July to December 2010 were enrolled. We defined colorectal neoplasia as tubular adenoma, advanced adenoma, or cancer. We performed a logistic regression analysis to investigate the correlations between obesity and colorectal neoplasia and a receiver operating characteristic (ROC) curve analysis to determine the cut-off obesity marker values for detecting colorectal neoplasia. Results Among the total of 268 subjects, 83 (31.0%) subjects had colorectal neoplasia. Subjects with neoplasia had higher BMI, WC, and WHtR than the subjects without any neoplasia. The adjusted odds ratio (aOR) of WHtR ≥0.5 with the association of neoplasia was 1.927 (95% confidence interval [CI], 1.041–3.569) in the total subjects. In women, the obesity markers of WC ≥85 cm (aOR 4.611; 95% CI, 10.166–18.240) and WHtR ≥0.5 (aOR 1.747; 95% CI, 1.149–19.617) were significantly related to neoplasia; however, there was no significant result in men. The ROC analysis showed the optimal cut-off values of BMI as >23.14 kg/m 2 ( P =0.002), WHtR as >0.50 ( P <0.001), and WC as>82.5 cm ( P =0.650) in men and >77 cm in women ( P <0.001). Conclusion Obesity is significantly associated with the increased risk of colorectal neoplasia. WC and WHtR have more significant correlations with neoplasia; thus, obese people should undergo regular colonoscopy screenings to detect colorectal neoplasia.

show abstract

Section: Discussionsupporting

confidence: 90%

Obesity Markers as Predictors for Colorectal Neoplasia

Kwon

Youn

et al. 2017

JOMES

View full text Add to dashboard Cite

show abstract

“…Multiple risk factors were identified including increasing age, smoking, black race, obesity, low fibre diet, insulin resistance, and the metabolic syndrome. There is sharp increase in incidence of metabolic syndrome worldwide which is defined as the presence of at least three of the following components: increased waist circumference, hypertriglyceridaemia, low high-density lipoprotein (HDL), hypertension, and hyperglycaemia (Kaneko et al,2014).…”

Section: Introductionmentioning

confidence: 99%

Potential Benefit of Metformin as Treatment for Colon Cancer: the Evidence so Far

A¹,

Husain²,

Hassan³

et al. 2016

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Metformin is known as a hypoglycaemic agent that regulates glucose homeostasis by inhibiting liver glucose production and increasing muscle glucose uptake. Colorectal cancer (CRC) is one of the most common cancers worldwide, with about a million new cases diagnosed each year. The risk factors for CRC include advanced age, smoking, black race, obesity, low fibre diet, insulin resistance, and the metabolic syndrome. We have searched Medline for the metabolic syndrome and its relation to CRC, and metformin as a potential treatment of colorectal cancer. Administration of metformin alone or in combination with chemotherapy has been shown to suppress CRC. The mechanism that explains how insulin resistance is associated with CRC is complex and not fully understood. In this review we have summarised studies which showed an association with the metabolic syndrome as well as studies which tackled metformin as a potential treatment of CRC. In addition, we have also provided a summary of how metformin at the cellular level can induce changes that suppress the activity of cancer cells.

show abstract

“…16 As a newly developed anthropometric parameter, waist to height index (WHI) was associated with an increased risk of colorectal cancer in female Japanese subjects, but no further study has been reported. 17 Another newly introduced anthropometric parameter, body adiposity index (BAI), has been recognized as an index ofestimating percentage of body fat, but the largely inconsistent results achieved with body adiposity index warrant more explorations of this index.…”

Section: Introductionmentioning

confidence: 99%