A new index (CHOLINDEX) in detecting coronary artery disease risk

Akpınar, Onur; Bozkurt, Abdi; Acartürk, Esmeray; Şeydaoğlu, Gülşah

doi:10.5152/akd.2013.098

Cited by 20 publications

(30 citation statements)

References 24 publications

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“…The atherogenic index and lipid ratios were calculated using the following established formulas:[1021]…”

Section: Methodsmentioning

confidence: 99%

“…Studies have, however, demonstrated that in times when the conventional lipid parameters (TG, HDL-C, LDL-C, and TC) remain apparently normal, lipid ratios such as the Castelli's risk index-I (CRI-I), CRI-II, atherogenic coeefficient (AC), CHOLIndex, and the atherogenic index of plasma (AIP) are the diagnostic alternatives that have been shown in predicting the risk of developing cardiovascular events[9101112] and effectiveness of therapy. [13] CRI-I (also known as cardiac risk ratio [CRR]) has been particularly shown to reflect coronary plaques formation and the thickness of intima-media in the carotid arteries of young adults.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of dyslipidemia, lipid ratios, and atherogenic index as cardiovascular risk factors among semi-urban dwellers in Nigeria

2016

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Background and Objectives:The increasing frequency of cardiovascular disease (CVD) rests on the presence of major cardiovascular risk factors including dyslipidemia. This dyslipidemia is also a target for the prevention and treatment of many cardiovascular diseases. Hence, identification of individuals at risk of CVD is needed for early identification and prevention. The study was carried out to evaluate dyslipidemia using the lipid ratios and indices instead of just the conventional lipid profile.Methodology:It was a cross-sectional study with 699 participants recruited from semi-urban communities in Nigeria. Anthropometric indices, blood pressure, and fasting lipid profiles were determined. Abnormalities in lipid indices and lipid ratios with atherogenic index were also determined. SPSS software version 17.0 were used for analysis, P < 0.05 was considered statistically significant.Results:There were 699 participants with a mean age of 64.45 ± 15.53 years. Elevated total cholesterol, high low-density lipoprotein-cholesterol, elevated triglyceride, and low high-density lipoprotein were seen in 5.3%, 19.3%, 4.4%, and 76.3% of the participants, respectively. The Castelli's risk index-I (CRI-I) predicted the highest prevalence of predisposition to cardiovascular risk (47.8%) with females being at significantly higher risk (55.2% vs. 29.3%, P < 0.001). Atherogenic coefficient, CRI-II, CHOLIndex, atherogenic index of plasma (AIP) predicted a cardiovascular risk prevalence of 22.5%, 15.9%, 11.2%, and 11.0%, respectively, with no significant difference in between the sexes.Conclusions:Serum lipid ratios and AIP may be used in addition to lipid parameters in clinical practice to assess cardiovascular risks even when lipid profiles are apparently normal. AIP was more gender specific amidst the lipid ratios.

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“…The atherogenic index and lipid ratios were calculated using the following established formulas:[1021]…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of dyslipidemia, lipid ratios, and atherogenic index as cardiovascular risk factors among semi-urban dwellers in Nigeria

2016

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“…Lipid abnormality was defined as raised TG level ≥ 150mg/dL, reduced HDL-Cholesterol - <40mg/dL in males and < 50mg/dL in females and TC level ≥ 200mg/dL [ 15 ]. The atherogenic index and lipid ratios were calculated using the following established formulas [ 16 , 17 ].…”

Section: Methodsmentioning

confidence: 99%

Dyslipidaemia as a risk factor in the occurrence of stroke in Nigeria: prevalence and patterns

Olamoyegun¹,

Akinlade²,

Fawale³

et al. 2016

Pan Afr Med J

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IntroductionStroke is a major public health problem worldwide. Hypertension, diabetes mellitus, dyslipidaemia and smoking are some of the common modifiable risk factors in the occurrence of stroke. Therefore, this study was designed to assess the prevalence and patterns of dyslipidaemia among individuals with acute stroke.MethodsThis is a retrospective descriptive cross-sectional study, carried out in the Departments of Medicine at the LAUTECH Teaching hospital, Ogbomoso and General Hospital, Orile-Agege, Lagos, South-West, Nigeria, over a 18-month period between September 2012 and February 2014. One hundred and six (106) patients with acute stroke confirmed with computed tomography (CT) brain scan were recruited. Clinical features, risk factors, lipid profiles and stroke patterns were identified.ResultsMean age was significantly higher in ischaemic stroke compared to haemorrhagic (64.08±10.87 Vs, 56.21±12.38years, p=0.001). There was slight male preponderance in both stroke types (1.3:1). Out of 106 patients, 65 (61.3%) had ischaemic stroke, 38 (35.8%) intracerebral haemorrhage and 3 (2.9%) with subarachnoid haemorrhage. Dyslipidaemia is the most frequent risk factor (85.9%), followed by hypertension (66.0%) and diabetes mellitus (15.1%). Dyslipidaemia was significantly higher in the ischaemic stroke compared to haemorrhagic. Reduced HDL-cholesterol is the most prevalent fraction of lipid abnormalities (74.5%).ConclusionDyslipidaemia, particularly low HDL-C, was the most frequent risk factor in our patients with stroke. Hence, prevention of dyslipidaemia as well as other risk factors is key to reducing the burden of stroke in our country.

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“…Yüksek TG düzeyleri de KAH için diğer risk faktörlerinden biridir (10). Son yıllarda risk değerlendirmesinde TK/HDL-K, LDL-K/HDL-K, Non-HDL-K ve TG/HDL-K gibi değişik hesaplamaların değerlendirilmesi de öne sürülmüştür (11). Fakat LDL-K/HDL-K oranında TG düzeyleri ihmal edildiğinden bu hesaplama yetersiz kabul edilmiştir (12 Arsenault ve ark.…”

Section: Discussionunclassified

Lipid panel with Non-HDL cholesterol and total cholesterol/HDL cholesterol ratio

Yüksel¹,

Kaplan²,

Çelepkolu³

et al. 2015

Turk J Bioch

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Objective: In our study, the importance of the computational tests such as non-HDL cholesterol and Total cholesterol to HDL ratio for evaluating blood lipid levels were investigated. Method: The measured and calculated lipid parameters of 683 patients whose test inputs were done from Family Medicine Clinic were evaluated. The number of the patients were determined who had high Non-HDL cholesterol and total cholesterol / HDL cholesterol however the the routine lipid parameters were in the acceptable range. Results: According to our results, 45 (6.6%) patients had high non-HDL cholesterol values and 127 (%18,6) patients had high TC / HDL-cholesterol levels. Also, there were 11 (1.6%) patients with high non-HDL-cholesterol levels, and 39 (%5,7) patients with high TC / HDL cholesterol ratio, while all routine lipid parameters were in acceptable limits. Conclusion:The addition of Non-HDL cholesterol and TC / HDL-cholesterol ratio to routine laboratory results would be beneficial because it can create an alert to clinicians in terms of lipid disorders.Anahtar Kelimeler: Non-HDL kolesterol, TK/HDL kolesterol oranı, lipid parametreleri.

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A new index (CHOLINDEX) in detecting coronary artery disease risk

Cited by 20 publications

References 24 publications

Evaluation of dyslipidemia, lipid ratios, and atherogenic index as cardiovascular risk factors among semi-urban dwellers in Nigeria

Evaluation of dyslipidemia, lipid ratios, and atherogenic index as cardiovascular risk factors among semi-urban dwellers in Nigeria

Dyslipidaemia as a risk factor in the occurrence of stroke in Nigeria: prevalence and patterns

Lipid panel with Non-HDL cholesterol and total cholesterol/HDL cholesterol ratio

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