A new Z′=(2+0.5+0.5) amidophosphoester structure: Hirshfeld surface analysis of symmetry-independent molecules

Abstract

Tetraethyl 1,3-phenylenebis(phosphoramidate) was synthesized and characterized by

Conformational flexibility in amidophosphoesters: a CSD analysis completed with two new crystal structures of (C6H5O)2P(O)X [X = NHC7H13 and N(CH2C6H5)2]

“…The relationship between conformational behaviour and molecular packing has been extensively studied, and there are many examples of conformations imposed by intra-and intermolecular interactions and conformational preferences, typically in organotin systems (Buntine et al, 1998), amides and acids (Dauber & Hagler, 1980) and polypeptide chains (Gregoret & Cohen, 1991). The effect of conformational flexibility on the existence of two (or more) symmetry-independent molecules in the crystal, disordered structures and the formation of polymorphs were also ISSN 2053ISSN -2296 # 2020 International Union of Crystallography studied (Toghraee et al, 2011;Keikha et al, 2017;Vahdani Alviri et al, 2018;Bernstein & Hagler, 1978).…”

The synergistic co-operation of N—H...O=P hydrogen bonds and C—H...OX weak intermolecular interactions (X is =P or —C) in the (CH3O)2P(O)(NH–NHC6F5) amidophosphoester: a combined X-ray crystallographic and theoretical study

“…The P O bond lengths are within the standard range for analogous compounds (Keikha et al, 2017) and are longer than the normal P O bond length (1.45 Å ; Corbridge, 1995). The P-N bond lengths are standard for structures with an (O) 2 (N)P(O) skeleton (Sabbaghi et al, 2019) and less than a typically average P-N bond length (Corbridge, 1995).…”

Synthesis, spectroscopic characterization, crystal structure and hirshfeld surface analysis of (4-Cl-C6H4O)(OC4H8N)2PO amodiphosphoester

“…the compounds typically with the (RO) 2 (R 1 R 2 N)P(O) or (RO)(R 1 R 2 N) 2 P(O) formulas. 1,2 The extensive investigations on the biochemical properties of amidophosphoesters revealed various possibilities for their application in preparation of different classes of drugs, insecticides and pesticides. [3][4][5] Some amidophosphoesters are well-known as inhibitor of acetylcholinesterase (AChE) enzyme, which is responsible for the degradation of acetylcholine, a neurotransmitter involved in the process of learning and memory.…”