A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus

Abed, Charline; Legrave, Nathalie; Dufies, Maeva; Robert, Guillaume; Guérineau, Vincent; Vacelet, Jean; Auberger, Patrick; Amade, Philippe; Mehiri, Mohamed

doi:10.3390/md9071210

Cited by 20 publications

(24 citation statements)

References 25 publications

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“…S. spinosulus is amassive horny sponge with a regular conulose,black to grey surface, and white to light brown interior. This photophilousdemosponge is commonly found in shallow waters, mainly in the Western Mediterranean coasts (Abed et al, 2011;Mercurio et al, 2013;Murray et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…spinosulus(named Irciniaspinosula in previous works) is a natural producer of linear polyprenylhydroquinones (Cimino et al, 1972). This group of aromatic organic compounds exhibit moderate antibacterial, antiviral, anti-inflammatory and cytotoxic activities (Abed et al, 2011). Moreover, it comprises precursors of a new class of drugs regulating glutamatergic and cholinergic transmission in the mammalian central nervous system (Bisio et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Life cycle assessment of in situ mariculture in the Mediterranean Sea for the production of bioactive compounds from the sponge Sarcotragus spinosulus

Pérez‐López

Ledda

Bisio

et al. 2017

Journal of Cleaner Production

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Marine sponges are one of the most diverse invertebrates and show a great ability to produce valuable natural products with high biological activities. The main bottleneck for the commercial exploitation is the need of continuous biomass production in sufficient amount. In this study, the in situ cultivation of the sponge Sarcotragusspinosulus insea-based farming structures was evaluated according to the Life Cycle Assessment (LCA) standardized methodology. The results demonstrated that the cultivation aiming at the extraction of bioactive moleculeshad a more environmentally-friendly performancethanthe subsequent downstream processes, which were the main cause of the impact. Moreover, the simulation of alternative scenarios showed the possibility of achieving remarkable reductions of impact, as well as the effect of changes in key issues of the process: the effect of different approaches in the use of boats (exclusively used for the sea-based farming plants and the sponges collection or shared for other activities) as well as the influence of the survival rate.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Life cycle assessment of in situ mariculture in the Mediterranean Sea for the production of bioactive compounds from the sponge Sarcotragus spinosulus

Pérez‐López

Ledda

Bisio

et al. 2017

Journal of Cleaner Production

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“…Moreover, this species has also been found to contain terpenes with cytotoxic effects against cancer cells (Liu et al, 2001) and possible antitumor activities, which is a finding that should be confirmed through further study (Abed et al, 2011). In addition, other sponge-derived terpenoids could possess anti-inflammatory properties.…”

Section: Secondary Metabolites Of Sponges With Diverse Bioactivitiesmentioning

confidence: 61%

Application of in situ Solid-Phase Microextraction on Mediterranean Sponges for Untargeted Exometabolome Screening and Environmental Monitoring

et al. 2019

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In marine ecosystems, sponges are ubiquitous sessile organisms that contain a wide range of specialized metabolites. These metabolites point to a diverse range of biochemical pathways. Some of these compounds are biomarkers that indicate the presence of bacteria that form symbiotic relationships with a host sponge (microsymbionts). Sponges hold considerable promise as bioindicators for seawater quality monitoring, as they are exposed to, and accumulate, significant levels of anthropogenic contamination in coastal areas. Solid-phase microextraction (SPME) is a low-invasive and non-exhaustive technique that combines sampling and extraction into a single step and offers the added benefit of biocompatible extraction phases. We used different types of SPME devices to extract exometabolites from sponges (genus: Sarcotragus) in situ. Following extraction, the samples were analyzed via GC-and LC-MS in order to verify the presence of compounds associated with quorum sensing, as well as to examine the metabolism of organic pollutants, such as monocyclic aromatic hydrocarbons (MAHs), polycyclic aromatic hydrocarbons (PAHs), pesticides, and other bioactive compounds in an untargeted format. As the results demonstrate, when the extracted metabolites are compared with the background controls, SPME offers a nonexhaustive approach that can be used in the field to discover novel metabolites deriving from complex holobionts such as marine sponges.

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“…All isolated compounds were identified by comparison of their spectral data (see Supplementary Material, available online at http://dx.doi.org/10.1155/2016/5318176) with the literature values [16, 26, 39–44]. …”

Section: Methodsmentioning

confidence: 99%

In VitroGrowth Inhibitory Activities of Natural Products from Irciniid Sponges against Cancer Cells: A Comparative Study

Romdhane

Elbour

Carbone

et al. 2016

BioMed Research International

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Marine sponges of the Irciniidae family contain both bioactive furanosesterterpene tetronic acids (FTAs) and prenylated hydroquinones (PHQs). Both classes of compounds are known for their anti-inflammatory, antioxidant, and antimicrobial properties and known to display growth inhibitory effects against various human tumor cell lines. However, the different experimental conditions of the reported in vitro bioassays, carried out on different cancer cell lines within separate studies, prevent realistic actual discrimination between the two classes of compounds from being carried out in terms of growth inhibitory effects. In the present work, a chemical investigation of irciniid sponges from Tunisian coasts led to the purification of three known FTAs and three known PHQs. The in vitro growth inhibitory properties of the six purified compounds have been evaluated in the same experiment in a panel of five human and one murine cancer cell lines displaying various levels of sensitivity to proapoptotic stimuli. Surprisingly, FTAs and PHQs elicited distinct profiles of growth inhibitory-responses, differing by one to two orders of magnitude in favor of the PHQs in all cell lines. The obtained comparative results are discussed in the light of a better selection of drug candidates from natural sources.

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A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus

Cited by 20 publications

References 25 publications

Life cycle assessment of in situ mariculture in the Mediterranean Sea for the production of bioactive compounds from the sponge Sarcotragus spinosulus

Life cycle assessment of in situ mariculture in the Mediterranean Sea for the production of bioactive compounds from the sponge Sarcotragus spinosulus

Application of in situ Solid-Phase Microextraction on Mediterranean Sponges for Untargeted Exometabolome Screening and Environmental Monitoring

In VitroGrowth Inhibitory Activities of Natural Products from Irciniid Sponges against Cancer Cells: A Comparative Study

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