A new hope in the treatment of intraventricular haemorrhage in preterm infants: mesenchymal stem cells

Bozkaya, Davut; Ceran, Burak; Özmen, Esra; Okman, Esin; Dizdar, Evrim Alyamaç; Oğuz, Şerife Suna; Bozkaya, İkbal Ok

doi:10.5137/1019-5149.jtn.34850-21.2

Cited by 6 publications

(13 citation statements)

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“… 17 The diagnosis of severe IVH (≥3 grade) was demonstrated by cranial ultrasonography. 18 NEC classification (≥2 grade) was made based on clinical and laboratory findings. 19 BPD was defined as patients with a need for oxygen <30% (moderate) or receiving ≥30% oxygen or positive pressure (severe) at the 36 th week of postmenstrual age.…”

Section: Methodsmentioning

confidence: 99%

“… 17 O diagnóstico de HIV grave (grau ≥3) foi demonstrado por ultrassonografia craniana. 18 A classificação ECN (grau ≥2) foi feita com base em achados clínicos e laboratoriais. 19 A DBP foi definida como pacientes com necessidade de oxigênio <30% (moderada) ou uso de oxigênio ≥30% ou pressão positiva (grave) na 36ª semana de idade pós-menstrual.…”

Section: Métodosunclassified

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Proporção de Largura de Distribuição de Hemoglobina/Glóbulos Vermelhos (HRR): Um Novo e Promissor Parâmetro de Glóbulos Vermelhos no Fechamento Ductal

Yildiz¹,

Çakır²,

Tugcu³

et al. 2023

Arquivos Brasileiros De Cardiologia

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Resumo Fundamento Ainda não está clara a eficácia dos parâmetros hematológicos no fechamento da persistência do canal arterial (PCA). Objetivos O objetivo principal do nosso estudo é investigar o efeito da proporção (HRR) de largura de distribuição de hemoglobina (HB) para glóbulos vermelhos (RDW) no fechamento do PCA. Métodos Bebês prematuros com muito baixo peso ao nascer (MBPN: <1.500 g) e <32 semanas gestacionais foram incluídos no estudo, e todos os dados foram registrados retrospectivamente. Características demográficas, resultados clínicos, parâmetros de hemácias e HRR e suas proporções foram comparados entre grupos de PCA hemodinamicamente significativa (hsPDA) e não-hsPDA. Todos os resultados foram analisados estatisticamente, e p<0,05 foi considerado estatisticamente significativo. Resultados Um total de 677 bebês prematuros, 269 no grupo hsPDA e 408 no grupo não-hsPDA, foram incluídos no estudo. Hemoglobina (HB), hematócrito (HCT), volume celular médio (VCM), glóbulos vermelhos (RBC), largura de distribuição dos glóbulos vermelhos (RDW), volume plaquetário médio (VPM), relação VCM/RBC, relação HB/RBC, RDW A razão /RBC e a razão RDW/VPM foram semelhantes entre os grupos hsPDA e não hsPDA, (p>0,05). HRR foi significativamente menor no grupo hsPDA [mediana (Quartil 1 (Q1) - Q3) (Q1 - Q3): 0,93 (0,8-1,0)] em comparação com não-hsPDA [mediana (Q1 - Q3): 1,07 ( 1,0-1,2)] (p<0,001). A AUC para o valor diagnóstico de HRR em hsPDA foi de 0,816 e o valor de corte foi ≤0,98 (p<0,001, 95% [IC]: 0,785-0,845, sensibilidade: 90%, especificidade: 92%). Conclusões O valor de HRR foi considerado um parâmetro eficaz e poderoso no diagnóstico de hsPDA.

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Section: Methodsmentioning

confidence: 99%

Section: Métodosunclassified

Proporção de Largura de Distribuição de Hemoglobina/Glóbulos Vermelhos (HRR): Um Novo e Promissor Parâmetro de Glóbulos Vermelhos no Fechamento Ductal

Yildiz¹,

Çakır²,

Tugcu³

et al. 2023

Arquivos Brasileiros De Cardiologia

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“…Sepsis in the first 72 hours after birth was defined as ENS, and sepsis after 72 hours was defined as LNS 14 . Preterm babies were evaluated with cranial ultrasonography every two days during the first week of life, and advanced stage (stage ≥3) IVC was recorded 15 . In clinical and echocardiographic evaluation, PDAs with hemodynamically significant ducts and requiring treatment were recorded 16 .…”

Section: Methodsmentioning

confidence: 99%

Preterm yenidoğanlarda gebelik yaşına göre küçük olmak ile tiroid fonksiyon testleri arasındaki ilişki

Yildiz

Çakır

Tugcu

et al. 2022

Cukurova Medical Journal

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Purpose: The aim of this study was to evaluate the relationship between thyroid hormone levels and clinical outcomes in preterm, small for gestational age (SGA) infants. Materials and Methods: The premature newborns (gestational age of ≤30 weeks) were divided into two groups as SGA and non-SGA. Thyroid stimulating hormone (TSH) and free thyroxine (fT4) levels, the frequency of congenital hypothyroidism (CH), demographic and clinical characteristics, morbidity and mortality rate were compared between the groups. Results: A total of 430 premature newborns, 72 in the SGA group and 358 in the non-SGA group were included. The frequency of CH, morbidity, demographic and clinical characteristics were similar between two groups. The mortality rate was higher in SGA (36.1%) than in non-SGA group (13.6%). Serum fT4 level was lower in SGA group (1.04±0.30 ng/dl) compared to the non-SGA group (1.24±0.33 ng/dl). The serum TSH level was higher in SGA group (9.91 ± 5.6 uIU/L) than in non-SGA group (6.6 ± 5.2 uIU/L). Conclusion: The frequency of thyroid dysfunction was higher in preterm SGA infants compared to non-SGA, which was due to transiently high TSH and low fT4 concentrations. Therefore, thyroid function tests should be monitored periodically in preterm and SGA infants.

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“…16 In the evaluation of transfontanel ultrasonography, infants with severe IVH (stage !3) were recorded. 17 According to clinical findings and Doppler echocardiography examination, infants with PDA requiring treatment (medical or surgical) were recorded. 18 Sepsis starting in the first 3 days was defined as EOS and sepsis starting after 3 days was defined as LOS.…”

Section: Definition Of Rds and Preterm Morbiditiesmentioning

confidence: 99%

Evaluation of the Effectiveness of Systemic Inflammatory Indices in the Diagnosis of Respiratory Distress Syndrome in Preterm with Gestational Age of ≤32 Weeks

Çakır¹,

Tugcu²,

Tayman³

et al. 2023

Am J Perinatol

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Objective: It is not yet known whether systemic inflammatory indices affect the development of respiratory distress syndrome (RDS) in premature infants. We aimed to evaluate the relationship between systemic inflammatory indices obtained on the first day of life and the development of RDS in premature infants. Study Design: Premature infants with gestational age of ≤32 weeks were included in the study. Six systemic inflammatory indices involving neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), and systemic inflammation response index (SIRI) were measured in the first 1 hours after birth and compared in premature infants with and without RDS. Results: A total of 931 premature infants, 579 infants in the RDS group and 352 infants in the non-RDS group, were included in the study. MLR, PLR, and SIRI values were similar between groups (p>0.05 for all parameters). NLR, PIV, and SII values in the RDS group were significantly higher than in the non-RDS group (p=0.005, p=0.011, and p<0.001, respectively). In the predictivity of RDS, the AUC value of SII was 0.842 and the cut-off value was ≥78.200. Multiple logistic analysis showed that a higher level of SII (≥78.2) was independently associated with RDS (OR 3.03, 95% CI 1.761-5.301). Conclusion: Our results demostrated that a higher SII level (≥78.2) may be a predictor for the development of RDS in premature infants with gestational age of ≤32 weeks.

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A new hope in the treatment of intraventricular haemorrhage in preterm infants: mesenchymal stem cells

Cited by 6 publications

References 0 publications

Proporção de Largura de Distribuição de Hemoglobina/Glóbulos Vermelhos (HRR): Um Novo e Promissor Parâmetro de Glóbulos Vermelhos no Fechamento Ductal

Proporção de Largura de Distribuição de Hemoglobina/Glóbulos Vermelhos (HRR): Um Novo e Promissor Parâmetro de Glóbulos Vermelhos no Fechamento Ductal

Preterm yenidoğanlarda gebelik yaşına göre küçük olmak ile tiroid fonksiyon testleri arasındaki ilişki

Evaluation of the Effectiveness of Systemic Inflammatory Indices in the Diagnosis of Respiratory Distress Syndrome in Preterm with Gestational Age of ≤32 Weeks

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