Evaluation of the Effectiveness of Systemic Inflammatory Indices in the Diagnosis of Respiratory Distress Syndrome in Preterm with Gestational Age of ≤32 Weeks

Çakır, Ufuk; Tugcu, Ali Ulas; Tayman, Cüneyt; Yildiz, Duran

doi:10.1055/a-2051-8544

Cited by 5 publications

(6 citation statements)

References 36 publications

(84 reference statements)

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“…In our study, GA, BW, leukocyte parameters and systemic inflammatory indices were similar in both genders, as well as the frequency of RDS and BPD was higher in males. In a newly published study, it has been shown that high SII values may be a predictor for RDS in preterms ≤32 weeks of gestational age 40 . In another recent study, it has been reported that high SIRI values for both at birth and at the 36 th week of postmenstrual age could be a predictor marker for moderate to severe BPD in prematures <32 weeks of gestational age 41 .…”

Section: Resultsmentioning

confidence: 99%

Prematüre bebeklerde cinsiyet ve doğum şeklinin sistemik inflamatuar indeksler üzerine etkisi

TAYMAN,

ÇAKIR

2023

Cukurova Medical Journal

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Section: Resultsmentioning

confidence: 99%

Prematüre bebeklerde cinsiyet ve doğum şeklinin sistemik inflamatuar indeksler üzerine etkisi

TAYMAN,

ÇAKIR

2023

Cukurova Medical Journal

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“…PIV is a marker that integrates various markers of inflammation and immune system and has shown promise as a predictor of prognosis in different diseases [15,16]. It has been studied in various cancer types, including esophageal, colorectal, and breast cancer [11][12][13].…”

Section: Discussionmentioning

confidence: 99%

“…PIV has been proposed as a biomarker in other medical conditions as well. It has been evaluated in the diagnosis of respiratory distress syndrome in preterm infants [ 15 ]. In the field of pediatric acute-onset neuropsychiatric syndrome (PANS), which is associated with immune abnormalities, PIV has been studied in the context of treatment outcomes [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Pan-Immune-Inflammation Index as a Biomarker for Rheumatoid Arthritis Progression and Diagnosis

Tutan,

Doğan

2023

Cureus

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Introduction Rheumatoid arthritis (RA) is a chronic autoimmune condition that causes systemic inflammation and affects multiple joints. It is characterized by joint warmth, swelling, pain, and the formation of invasive synovial tissue known as pannus, which contributes to cartilage and bone degradation. Pan-immune-inflammation value (PIV), a marker derived from complete blood count parameters, has shown promise in predicting prognosis in various cancer types and pediatric conditions associated with immune abnormalities. This study aims to explore the relationship between RA, characterized by chronic inflammation and immune system involvement, and PIV, potentially shedding light on novel insights into RA's clinical implications. Methods One hundred four participants, including 64 RA patients (both newly diagnosed and established cases) and 40 healthy controls, were included in the study. Exclusion criteria for RA patients included acute infection, cancer, diabetes, or chronic illness, while control participants were excluded for inflammatory disorders, active infection, diabetes, or malignancy. We assessed disease severity using Disease Activity Score 28 (DAS 28) and obtained complete blood count values, including neutrophil, lymphocyte, platelet, monocyte, and red cell distribution width. C-reactive peptide (CRP) and erythrocyte sedimentation rate were also added. Statistical analyses included correlation assessments, t-tests, Mann-Whitney U tests, and multivariate linear regression. A multiclass receiver operating characteristic analysis determined optimal PIV cut-off values for distinguishing control, remission, and active RA groups, with sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), accuracy, and odds ratios calculated. Results This study comprised a cohort of 104 participants, with a median age of 43.5±17.5. The Remission group was significantly younger than the Control group (p=0.006) but not compared to the Active RA group (p=0.393). CRP levels were significantly higher in the Active RA group (p<0.001). Neutrophil counts were highest in the Active RA group (p<0.001), as were monocyte counts. Lymphocyte counts were significantly lower in the Active RA group (p<0.001). There were no significant differences in sedimentation rate, hemoglobin, platelet count, and mean platelet volume. PIV was significantly elevated in the Active RA group (p<0.001) and higher in the Remission group than in the Control group (p=0.001). A PIV value of 353.48 exhibited 71.4% sensitivity, 86.2% specificity, 86.2% PPV, 71.4% NPV, and 78.13% test accuracy for distinguishing active rheumatoid arthritis (p<0.001). A PIV value exceeding 353.48 substantially increased the likelihood of a patient belonging to the active rheumatoid arthritis group, with a 14.62-fold higher probability. Furthermore, the study explored the relationship between clinical and laboratory variables and disease activity in RA patients, finding significant diffe...

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“…In our results, the AUC value of SII for the predictivity of mortality in VLBW infants was 0.844, and the cutoff value was ≤28.87. It has been reported that an SII level ≥78.2 after birth may be a risk factor for the development of RDS in preterms ≤32 weeks of gestation 15 . It was found that the high SIRI value could predict moderate to severe BPD in preterm infants 16 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the efficacy of systemic inflammatory indices in determining mortality in very low birth weight infants

Çakır¹,

Tayman²,

Tugcu³

2023

Rev. Assoc. Med. Bras.

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OBJECTIVE:In our study, we aimed to investigate whether systemic inflammatory indices could be an indicator of mortality in very low birth weight (<1,500 g) preterm infants. METHODS: Very low birth weight preterm infants were included in our study, and patient data were recorded retrospectively. Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, systemic immune-inflammation index, pan-immune-inflammation value, and systemic inflammation response index were calculated and recorded. The survivors and infants who died were compared for systemic inflammatory indices. RESULTS: A total of 1,243 very low birth weight infants were included in the study. Of the patients, 1,034 survived and 209 died. Neutrophil-tolymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, pan-immune-inflammation value, systemic immune-inflammation index, and systemic inflammation response index were found to be statistically significantly lower in the mortality group than those in the survivor group (p=0. 039, p=0.001, p<0.001, p<0.001, p<0.001, and p=0.002, respectively). According to the receiver operating curve analysis, systemic immuneinflammation index with the highest area under the curve (0.844) was found to be the most effective systemic inflammatory indices in predicting mortality with a cutoff level of ≤28.87 (p=0.0001). Multiple regression analysis showed that a lower level of systemic immune-inflammation index (≤28.87) was independently associated with mortality (OR: 1.677, 95%CI 1.061-2.685, p=0.001). CONCLUSION: We have shown that low systemic immune-inflammation index value in very low birth weight preterm infants may be a novel systemic inflammatory index that can be used to predict mortality.

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Evaluation of the Effectiveness of Systemic Inflammatory Indices in the Diagnosis of Respiratory Distress Syndrome in Preterm with Gestational Age of ≤32 Weeks

Cited by 5 publications

References 36 publications

Prematüre bebeklerde cinsiyet ve doğum şeklinin sistemik inflamatuar indeksler üzerine etkisi

Prematüre bebeklerde cinsiyet ve doğum şeklinin sistemik inflamatuar indeksler üzerine etkisi

Pan-Immune-Inflammation Index as a Biomarker for Rheumatoid Arthritis Progression and Diagnosis

Evaluation of the efficacy of systemic inflammatory indices in determining mortality in very low birth weight infants

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