A new frontier in therapy personalisation based on in vitro studies to preserve fertility potential of men

Abstract

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Fertility Preservation in Pediatric Age: Future Perspective among Andrological Diseases

“…We have studied varicocele in all molecular and biological aspects, and still many studies are necessary. However, even today, despite surgery, some patients have alterations in the quality of seminal fluid and require medically-assisted procreation as adults [ 13 , 14 , 15 , 16 ].…”

“…In the lab, we demonstrated how many testicular pathologies affect both testicular vascularity and hormone control. In these patients, offering both preservation of testicular tissue and a clinical path until the control of seminal fluid is crucial to exclude future fertility problems [ 14 , 15 , 16 ].…”

“…Since January 2022, 101 testicular tissues have been cryopreserved, including three samples for cancer disease in pre-pubescent patients. Most patients suffered from cryptorchidism, testicular torsion, varicocele, and DSD (differences of sex development) [ 14 , 15 , 16 , 17 ].…”