2015
DOI: 10.1002/open.201402169
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A New Fluorescence Turn-On Probe for Aluminum(III) with High Selectivity and Sensitivity, and its Application to Bioimaging

Abstract: The development of novel selective probes with high sensitivity for the detection of Al3+ is widely considered an important research goal due to the importance of such probes in medicine, living systems and the environment. Here, we describe a new fluorescent probe, N′-(4-diethylamino-2-hydroxybenzylidene)-2-hydroxybenzohydrazide (1), for Al3+. Probe 1 was evaluated in a solution of acetonitrile/water (1:1 v/v). Compared with previously reported probes for Al3+, probe 1 can be synthesized easily and in high yi… Show more

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Cited by 19 publications
(13 citation statements)
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“…The fluorescence intensity of compound 2 increased almost linearly to the amount of Al 3+ but remained steady when more than 1.0 equiv of Al 3+ was applied (Figure C), suggesting a 1:1 binding mode between compound 2 and Al 3+ . To further investigate the binding stoichiometry of compound 2 and Al 3+ , Job’s plot analysis , (Figure S6) based on fluorescence spectra was performed, in which the transition point for fluorescence intensity appeared at the molar fraction of 0.5, suggesting that compound 2 bound to Al 3+ with a 1:1 molar ratio. Furthermore, the 1:1 binding stoichiometry between compound 2 and Al 3+ was also verified by ESI-MS spectrum of compound 2 and compound 2 /Al 3+ .…”
Section: Results and Discussionmentioning
confidence: 99%
“…The fluorescence intensity of compound 2 increased almost linearly to the amount of Al 3+ but remained steady when more than 1.0 equiv of Al 3+ was applied (Figure C), suggesting a 1:1 binding mode between compound 2 and Al 3+ . To further investigate the binding stoichiometry of compound 2 and Al 3+ , Job’s plot analysis , (Figure S6) based on fluorescence spectra was performed, in which the transition point for fluorescence intensity appeared at the molar fraction of 0.5, suggesting that compound 2 bound to Al 3+ with a 1:1 molar ratio. Furthermore, the 1:1 binding stoichiometry between compound 2 and Al 3+ was also verified by ESI-MS spectrum of compound 2 and compound 2 /Al 3+ .…”
Section: Results and Discussionmentioning
confidence: 99%
“…In contrast, 2 showed highly selective fluorescence quenching for Co 2+ ions (Figure , S26–27). It is noted that 2 e exhibited highly selective fluorescence enhancement for Al 3+ ions in CH 3 CN−H 2 O mixture . Co 2+ ions did not show any interference.…”
Section: Resultsmentioning
confidence: 84%
“…ESIPT fluorophores 1 – 4 were synthesized via simple Schiff base condensation reaction between HBH and different aldehydes (Scheme a, S1) . Amine precursor, HBH, was synthesized by reacting hydrazine and methyl salicylate.…”
Section: Resultsmentioning
confidence: 99%
“…Fluorescent approach is the most attractive and highly sensitive method to detect low concentrations of analysts [9]. In recent years, there has been considerable progress for the detection of aluminum utilizing fluorescent chemo-sensors [10,11,12,13,14,15]. However, there are still many limitations during the application of most reported fluorescent probes, such as working well only in anhydrous systems, poor selectivity or sensitivity, and weak binding ability [13,16,17,18,19].…”
Section: Introductionmentioning
confidence: 99%