A new experimental setup for time- and laterally-resolved X-ray absorption fine structure spectroscopy in a ‘single shot’

Kulow, Anicó; Witte, Steffen; Beyer, Sven; Buzanich, Ana Guilherme; Radtke, Martin; Reinholz, Uwe; Riesemeier, H.; Streli, Christina

doi:10.1039/c8ja00313k

Cited by 13 publications

(10 citation statements)

References 16 publications

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“…ZIF-8 is easily synthesized through simple precipitation reactions facilitated by mixing the ligand (2-methylimidazole) and zinc salt solution at room temperature ( Park et al, 2006 ; Beyer et al, 2016 , 2018b ; Kulow et al, 2019 ). ZIF-8 can be engineered to acquire bioactivity beyond that of zinc ions through encapsulation of drugs.…”

Section: Preparation Methods Of Mofs Suitable For Term Laboratories Amentioning

confidence: 99%

Metal-Organic Framework (MOF)-Based Biomaterials for Tissue Engineering and Regenerative Medicine

Shyngys

Ren

Xiao-qi

et al. 2021

Front. Bioeng. Biotechnol.

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The synthesis of Metal-organic Frameworks (MOFs) and their evaluation for various applications is one of the largest research areas within materials sciences and chemistry. Here, the use of MOFs in biomaterials and implants is summarized as narrative review addressing primarely the Tissue Engineering and Regenerative Medicine (TERM) community. Focus is given on MOFs as bioactive component to aid tissue engineering and to augment clinically established or future therapies in regenerative medicine. A summary of synthesis methods suitable for TERM laboratories and key properties of MOFs relevant to biomaterials is provided. The use of MOFs is categorized according to their targeted organ (bone, cardio-vascular, skin and nervous tissue) and whether the MOFs are used as intrinsically bioactive material or as drug delivery vehicle. Further distinction between in vitro and in vivo studies provides a clear assessment of literature on the current progress of MOF based biomaterials. Although the present review is narrative in nature, systematic literature analysis has been performed, allowing a concise overview of this emerging research direction till the point of writing. While a number of excellent studies have been published, future studies will need to clearly highlight the safety and added value of MOFs compared to established materials for clinical TERM applications. The scope of the present review is clearly delimited from the general ‘biomedical application’ of MOFs that focuses mainly on drug delivery or diagnostic applications not involving aspects of tissue healing or better implant integration.

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Section: Preparation Methods Of Mofs Suitable For Term Laboratories Amentioning

confidence: 99%

Metal-Organic Framework (MOF)-Based Biomaterials for Tissue Engineering and Regenerative Medicine

Shyngys

Ren

Xiao-qi

et al. 2021

Front. Bioeng. Biotechnol.

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“…Numerous studies have been performed with the aim of improving the performance of these setups for different applications. [49][50][51][52] In dispersive-XAS there is no scanning involved, as the whole polychromatic beam interacts with the sample and is then diffracted by a crystal. This results in more beam position stability.…”

Section: Time Resolved Xas/xes (Quick-xas Dispersive-xas Ultrafast-xas)mentioning

confidence: 99%

“…The other approach is dispersive‐XAS, which consists of diffraction a polychromatic beam—of a specific bandwidth—by a bent crystal (e.g., Si 111). Numerous studies have been performed with the aim of improving the performance of these setups for different applications 49–52 . In dispersive‐XAS there is no scanning involved, as the whole polychromatic beam interacts with the sample and is then diffracted by a crystal.…”

Section: Modus Operandi and Applicationsmentioning

confidence: 99%

Recent developments of X‐ray absorption spectroscopy as analytical tool for biological and biomedical applications

Buzanich

2021

X-Ray Spectrometry

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X-ray absorption spectroscopy (XAS), in its various modalities, has gained exponential attention and applicability in the field of biological and biomedical systems. Particularly in this field, challenges like low concentration of analyte or proneness to radiation damage have certainly settle the basis for further analytical developments, when using X-ray based methods. Low concentration calls for higher sensitivity-by increasing the detection limits (DL); while susceptibility for radiation damage requires shorter measurement times and/or cryogenic sample environment possibilities. This manuscript reviews the latest analytical possibilities that make XAS more and more adequate to investigate biological or biomedical systems in the last 5 years.Highlights in this review are: Combination of Imaging micro-X-ray Fluorescence spectroscopy (XRF) with XAS, by selecting multiple energies (ME); Total reflection XRF -XAS (TXRF-XAS); High energy resolution fluorescence detection XAS (HERFD-XAS) and resonant Xray emission spectroscopy (RXES); Time resolved XAS (Quick-XAS, Dispersive-XAS, Ultrafast-XAS).

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“…Thus, it is imperative to minimize the number of diffraction peaks during the experiment itself. This necessitates either minimizing the footprint of the beam on the diamond with a small and mechanically stable beam (Pascarelli et al, 2004(Pascarelli et al, , 2006(Pascarelli et al, , 2016Baudelet et al, 2011;Pascarelli & Mathon, 2010;Mathon et al, 2004Mathon et al, , 2015Kulow et al, 2019;Kantor et al, 2018) or replacing crystalline diamonds with (expensive) polycrystalline diamonds (Ishimatsu et al, 2012). The second problem with the DAC is a weakening of the signal-to-noise ratio (i.e.…”

Section: Introductionmentioning

confidence: 99%

First high-pressure XAFS results at the bending-magnet-based energy-dispersive XAFS beamline BL-8 at the Indus-2 synchrotron facility

et al. 2020

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The static focusing optics of the existing energy-dispersive XAFS beamline BL-8 have been advantageously exploited to initiate diamond anvil cell based high-pressure XANES experiments at the Indus-2 synchrotron facility, India. In the framework of the limited photon statistics with the 2.5 GeV bending-magnet source, limited focusing optics and 4 mm-thick diamond windows of the sample cell, a (non-trivial) beamline alignment method for maximizing photon statistics at the sample position has been designed. Key strategies include the selection of a high X-ray energy edge, the truncation of the smallest achievable focal spot size to target size with a slit and optimization of the horizontal slit position for transmission of the desired energy band. A motor-scanning program for precise sample centering has been developed. These details are presented with rationalization for every step. With these strategies, Nb K-edge XANES spectra for Nb2O5 under high pressure (0–16.9 GPa) have been generated, reproducing the reported spectra for Nb2O5 under ambient conditions and high pressure. These first HPXANES results are reported in this paper. The scope of extending good data quality to the EXAFS range in the future is addressed. This work should inspire and guide future high-pressure XAFS experiments with comparable infrastructure.

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A new experimental setup for time- and laterally-resolved X-ray absorption fine structure spectroscopy in a ‘single shot’

Abstract: A new, simple and adjustable setup allows scanning-free XAS for time-resolved studies of structural changes in chemical compounds.

Cited by 13 publications

References 16 publications

Metal-Organic Framework (MOF)-Based Biomaterials for Tissue Engineering and Regenerative Medicine

Metal-Organic Framework (MOF)-Based Biomaterials for Tissue Engineering and Regenerative Medicine

Recent developments of X‐ray absorption spectroscopy as analytical tool for biological and biomedical applications

First high-pressure XAFS results at the bending-magnet-based energy-dispersive XAFS beamline BL-8 at the Indus-2 synchrotron facility

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