A new electron paramagnetic resonance device to measure transcutaneous oxygen in humans

Sinusoidal changes in transcutaneous oxygen pressure, suggesting Cheyne-Stokes respiration, are frequent and of poor prognosis among patients with suspected critical limb ischemia

“…Clark-type electrodes are reported to provide a 90% response to an abrupt change in the value to be recorded, ranging from 20 to 25 s. [28] TcpO2 changes are comparable with photoelectric probes but seem to be slower with paramagnetic probes. [29,30] Therefore, it is uncertain whether the present results with Clark-type electrodes could be observed will all TcpO2 technologies. Cheyne-Stokes respiration (CSR), sometimes referred to as Hunter-Cheyne-Stokes breathing, is a type of breathing disorder characterized by cyclical episodes of apnea, followed by increasing then decreasing ventilation amplitude, resulting in sinusoidal changes in arterial pO2.…”

Application of SPOT chip for transcutaneous oximetry

“…We appreciate the interest of Henni et al in our work developing a new method for transcutaneous oxygen measurement in humans based on electron paramagnetic resonance (EPR) technology . We find the authors’ comments very useful and address the questions raised in the letter to the editor in the following.…”