A new electrochemical platform based on low cost nanomaterials for sensitive detection of the amoxicillin antibiotic in different matrices

Wong, Ademar; Santos, Anderson M.; Cincotto, Fernando Henrique; Moraes, Fernando C.; Fatibello‐Filho, Orlando; Sotomayor, Marı́a Del Pilar Taboada

doi:10.1016/j.talanta.2019.120252

Cited by 93 publications

(35 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The slope of −0.062 V/pH is close to the theoretical value of −0.059 V/pH given by the Nernstian equation with n = 1 that indicates the equal number of protons and electrons transfer process [ 54 , 55 ]. This result is in consonance with previous studies [ 26 , 27 , 30 , 56 ]. Accordingly, the electrochemical oxidation of AMX follows the mechanism as presented in Scheme 1 .…”

Section: Resultssupporting

confidence: 94%

“…Amoxicillin is an electroactive species and can therefore be quantified by electrochemical methods. The electrochemical oxidation of AMX was proposed by some authors [ 26 , 27 ], where the -OH group attached to the aromatic ring donates one electron to form the >C=O group. Due to the advantages of nanocarbon mentioned above, various applications of nanocarbon-based materials in electrode modification to improve the sensitivity of AMX detection were reported.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode

Pham

Trang

Nguyen

et al. 2021

Journal of Analytical Methods in Chemistry

View full text Add to dashboard Cite

A reduced graphite oxide nanosheet electrode (RGOnS) was prepared as a sensor for amoxicillin (AMX) detection, an antibiotic commonly used in the livestock farm, by the square-wave adsorptive stripping voltammetry technique. Graphite oxide with nanosheet shape was produced from a graphite electrode by a chronoamperometry process at 5 V and then an electrochemical reduction process was carried out to form RGOnS with restored long-range conjugated networks and better conductivity. The electrodes were characterized by SEM, EDX, and FTIR spectroscopy. The RGOnS electrode prepared at an optimal reduction potential of −1 V for 120 s exhibits a larger electrochemical active surface area, and the obtained oxidation signal of AMX is approximately ten times higher than that of the pristine graphite electrode. The analytical conditions such as the pH of electrolyte and accumulation time were optimized. The calibration curve built under the optimal conditions provided a good linear relationship in the range of AMX concentration from 0.5–80 µM with the correlation coefficient of 0.9992. The limit of detection was calculated as 0.193 µM. Satisfactory results are obtained from the detection of the AMX in different samples using the prepared electrode.

show abstract

Section: Resultssupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode

Pham

Trang

Nguyen

et al. 2021

Journal of Analytical Methods in Chemistry

View full text Add to dashboard Cite

show abstract

“…Figure 6B shows the influence of pH in the peak potential value, revealing a linear relationship with a slope of −0.067 V pH −1 that is value next to the theoretical Nernstian slope of −0.059 V pH −1 . This indicates that the redox process in this sensor corresponds to a system where the same number of protons and electrons are involved (Zeinali et al, 2018;Wong et al, 2020).…”

Section: Effect Of Phmentioning

confidence: 99%

Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples

et al. 2021

Self Cite

View full text Add to dashboard Cite

This work describes an electrochemical sensor for the selective recognition and quantification of amoxicillin and a β-lactam antibiotic in real samples. This sensor consists of a carbon paste electrode (CPE) modified with mag-MIP (magnetic molecularly imprinted polymer), which was prepared by precipitation method via free radical using acrylamide (AAm) as functional monomer, N,N′-methylenebisacrylamide (MBAA) as a crosslinker, and potassium persulfate (KPS) as initiator, to functionalized magnetic nanoparticles. The magnetic non-imprinted polymers (mag-NIP) were prepared using the same experimental procedure without analyte and used for the preparation of a CPE for comparative studies. The morphological, structural, and electrochemical characteristics of the nanostructured material were evaluated using Field emission gun scanning electron microscopy (FEG-SEM), Transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), Vibrating sample magnetometry (VSM), X-ray diffraction (XRD), and voltammetric technique. Electrochemical experiments performed by square wave voltammetry show that the mag-MIP/CPE sensor had a better signal response compared to the non-imprinted polymer-modified electrode (mag-NIP/CPE). The sensor showed a linear range from 2.5 to 57 μmol L−1 of amoxicillin (r2 = 0.9964), with a limit of detection and a limit of quantification of 0.75 and 2.48 μmol L−1, respectively. No significant interference in the electrochemical signal of amoxicillin was observed during the testing experiments in real samples (skimmed milk and river water). The proposed mag-MIP/CPE sensor could be used as a good alternative method to confront other techniques to determine amoxicillin in different samples.

show abstract

“…Chemical sensors target analytes such as chemical compounds found in urine (Wong et al, 2020), blood (Liu, Lee, et al, 2018) and human serum (Yang et al, 2017). These body fluids contain biomarkers, drugs and metabolites that can give valuable information about human health.…”

Section: Elec Tro Chemic Al Ba S Ed S Ensormentioning

confidence: 99%

Conducting polymers in wearable devices

et al. 2020

View full text Add to dashboard Cite

The increase interests in wearable device market are triggered by healthcare monitoring. Common examples are pulse, heart rate and temperature monitors. Wearable technology has opened up new path for non-invasive diagnostic and therapeutic technologies via sensing of biomarker/drug from the liquid extracted on skin including sweat (Bandodkar & Wang, 2014; Liu et al., 2017). The increasing demand of integrating electronic technology in wearable devices is driven by needs for individual monitoring remotely at home, often called as ubiquitous health care (Choudhuri et al., 2019). In addition, wearable devices allow continuous, long time monitoring at any place, anytime (Bohr et al., 2019). Mechanical and electrical responsive conducting polymers (CPs), plus high flexibility and stretch-ability contribute to recent accelerate growth of publications involving conducting polymer in wearable and skin-attachable device. Metals and silica (semiconductors) are inorganic materials that are generally regarded as highly conductive but are rigid and inflexible. The concept of organic conductors/semiconductors has arisen since the discovery of highly conducting polyacetylene by Hideki Shirakawa, working along with Alan MacDiarmid and physicist Alan Heeger in 1977 (Shirakawa et al., 1977). The most apparent advantage of organic electronics as compared to inorganic is that they are highly flexibility and they are lightweight. These properties are ideal for wearable sensors. Conducting polymers with long-term electrical and chemical stability such as polypyrrole (PPy), poly(3,4-ethylenedioxy-thiophene) (PEDOT) and polyaniline (PANi) (Figure 1) have gained popularity in this field (Puiggali-Jou et al., 2019; Talikowska et al., 2019). Doping counterions in close proximity to the extended pi-bond significantly improve CP conductivity. These doped CPs have electrical conductivities ranging from >1 S/cm to >1000 S/cm aligning CPs with the inorganic semiconductors, for example silicon

show abstract

A new electrochemical platform based on low cost nanomaterials for sensitive detection of the amoxicillin antibiotic in different matrices

Cited by 93 publications

References 49 publications

Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode

Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode

Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples

Conducting polymers in wearable devices

Contact Info

Product

Resources

About