A New, Efficient, and Catalyst-free Microwave-assisted Approach for Formation of O-tert-Butoxy Carbonates

Abstract

A new simple, efficient, greener, and catalyst-free chemoselective protocol for the O-tert-butoxycarbonylation of various structurally diverse hydroxy compounds was carried out with (Boc)2O under microwave radiation. The corresponding O-tert-butoxy carbonates were obtained in good to excellent yields in a short reaction time without any side reactions.

Lipase‐Catalyzed tert‐Butoxycarbonylation of Alcohols Using Boc2O

“…Under these conditions, however, the Boc‐protected alcohols have been frequently accompanied by the corresponding undesired symmetrical carbonates as byproducts . There have been reports on improving the methods for preparing Boc‐protected alcohols in the presence of catalysts such as CeCl 3 , V(O)(OTf) 2 , Zn(OAc) 2 , BiCl 3 , NaLaTiO 4 , mesoporous silica‐supported Er(III), MgO‐ZrO 2 nanoparticles, o ‐Py 4 Sn, and reduced graphene oxide, as well as by a catalyst‐free microwave‐assisted approach . Although these methods are useful under limited conditions, the production of Boc protected alcohols is still dependent on the alcohol structures.…”

A simple and highly efficient solvent- and catalyst-free synthesis of novelN-sulfamoyl imines

“…More recently, Zolfigol et al reported a green method for the synthesis of N-sulfonyl imines using WCl 6 as novel, highly facile and reusable catalyst (35). In continuation of our interest toward development of useful green synthetic methodology (36)(37)(38)(39)(40), we report the successful and efficient method for the synthesis of N-sulfonyl imines via the reaction of chloroethylsulfonamides with various aldehydes under solvent-and catalyst-free conditions.…”