A new diterpenoid from the leaves of Platycladus orientalis

Seasonal dynamics of the phenolic constituents of the cones and leaves of orientalThuja(Platycladus orientalisL.) reveal their anti-inflammatory biomarkers

“…All of them showed cytotoxic effects on cancer cells without toxic effects on normal cells. 17,18 Furthermore, four new compounds, namely, an abietane, two isopimarane diterpenes, and a dihydrobenzofuran neolignan, in addition to a new sesquiterpene glycoside were tested for their inhibitory effects on nitric oxide and TNF-α production; all tested compounds showed inhibitory effects. 19 Moreover, isocupressic acid reduced cognitive deficits in an AD (Alzheimer's disease) model via modulation of the Aβ peptide aggregation pathway.…”