A new disinfectant compound

Tsao, Te Chen; Williams, D. E.; Worley, S. D.

doi:10.1021/ie00106a032

Cited by 22 publications

(21 citation statements)

References 6 publications

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“…The rates of inactivation of the bacteria are related to the stabilities toward direct transfer of the Cl + moiety to the cells. Therefore, in general amide N-halamines can kill bacteria more rapidly than do amine N-halamines (Tsao et al 1990;Akdag et al 2006;Qian and Sun 2004). Thus chlorinated 1 and 2 siloxanes demonstrated bacterial inactivation more rapidly than cotton swatches coated with chlorinated 3 and 4 siloxanes because they have amide N-halamine functionalities, while 3 and 4 siloxanes have amine N-halamine groups.…”

Section: Biocidal Efficacy Testingmentioning

confidence: 99%

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Antimicrobial efficacy and light stability of N-halamine siloxanes bound to cotton

et al. 2008

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N-halamine silane syntheses and coatings of cotton fabrics as siloxanes were addressed for a series of silanes. The coated fabrics were chlorinated by exposure to dilute sodium hypochlorite with a range of chlorine loadings from 0.20% to 0.26%. Two types of N-Cl moieties were involved in the N-halamine siloxanes, amine and amide. The siloxane-coated cotton swatches were very effective in inactivating Escherichia coli O157:H7 and Staphylococcus aureus, each in 10 min contact time. The N-Cl bond and compound stabilities under UV irradiation and ambient light exposure were also investigated. Both UV and laboratory light stability tests show that most of the chlorine on cotton coated with 3-(3-triethoxysilylpropyl)-7, 7,9,9-tetramethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione could be regenerated after irradiation, while most of the lost chlorine from 5,5-dimethyl-3-(3 0 -triethoxysilylpropyl)hydantoin and 4-[3-triethoxysilylpropoxyl]-2,2,6,6-tetramethylpiperidine could not be recovered upon rechlorination.

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Section: Biocidal Efficacy Testingmentioning

confidence: 99%

“…N-halamine compounds containing either N-Cl or N-Br moieties have shown excellent efficacies in inactivating a wide range of microorganisms by the transfer of the oxidative halogen atoms to acceptor sites on the microorganisms (Worley and Williams 1988;Worley and Sun 1996;Tsao et al 1990;Makal et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial efficacy and light stability of N-halamine siloxanes bound to cotton

et al. 2008

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“…Thus they have considerable potential for use in various disinfection applications. Preliminary data for compound DC were presented in a recent communication (Tsao et al, 1990). This paper will discuss the properties of these new disinfectant compounds in greater depth.…”

Section: Introductionmentioning

confidence: 97%

Novel N‐Halamine Disinfectant Compounds

Tsao

Williams

Worley

et al. 1991

Biotechnology Progress

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A new series of N-halamine compounds has been synthesized and tested for stability in aqueous solution and efficacy in inactivating several species of bacteria and algae.The compounds, which are N,N'-dihalo-4-imidazolidinones, are inexpensive t o synthesize and appear to have considerable potential as general-purpose disinfectants. They have greater stability in the laboratory, as well as outdoors in direct sunlight, than do current commercial swimming pool biocides. They also are efficient at sterilizing hard surfaces (stainless steel) and could thus be useful for a variety of household and medical disinfection applications.

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“…Temporary antimicrobial fabrics can be achieved easily, but also their biocidal functionality is subjected to loss in laundering. N-halamine materials have been developed and shown to be effective biocides in these laboratories during the past two decades (Tsao, Williams, & Worley, 1990;Worley & Sun, 1996;Worley & Williams, 1988). The outstanding advantages of these N-halamine compounds are their durable and rechargeable antimicrobial properties when these compounds can be covalently bound to the substrates (Grunzinger et al, 2007;Makal, Wood, Ohman, & Wynne, 2006).…”

Section: Introductionmentioning

confidence: 99%