A new deferiprone controlled release system obtained by ultrasound-assisted compression

Aguilar-de-Leyva, Ángela; Gonçalves-Araújo, Tamara; Daza, Verónica; Caraballo, Isidoro

doi:10.3109/10837450.2013.829091

Cited by 9 publications

(4 citation statements)

References 23 publications

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“…So, the boundaries between particles become indistinguishable causing the sintering of the system. Some researchers have also confirmed the sintering process obtained with USAC by SEM [5,6,7,30]. It can be highlighted that acicular drug particles tend to be distributed in parallel thus offering the lowest porosity previously measured, and how TPU works binding these particles (Figure 5A,B).…”

Section: Resultssupporting

confidence: 64%

“…This technology has been successfully employed for different applications as the amorphization of active pharmaceutical ingredients, production of solid dispersions to enhance the bioavailability of poorly soluble drugs and formulation of sustained drug release forms [3,6,7,8,9,10]. In the case of prolonged release systems, USAC appears as a promising technique, decreasing the cost and the quantity of excipient needed for the control of the drug release [8], which usually constitutes an important drawback in the formulation of sustained-release systems.…”

Section: Introductionmentioning

confidence: 99%

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Achieving High Excipient Efficiency with Elastic Thermoplastic Polyurethane by Ultrasound Assisted Direct Compression

2019

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Ultrasound assisted compression (USAC) is a manufacturing technique which applies thermal and mechanical energy to the powder bed, producing tablets with improved characteristics compared to the direct compression process. This technology is ideal for thermoplastic materials, as polyurethanes, whose particles usually undergo a sintering process. Thermoplastic polyurethanes are widely used in sustained drug release systems but rarely seen in tablets due to their elastic properties. The aim of this work is to investigate the ability of USAC to manufacture sustained release matrix tablets based on elastic thermoplastic polyurethanes (TPU), overcoming the limitations of direct compression. The technological and biopharmaceutical characteristics of the TPU matrices have been evaluated, with special focus on the porous structure due to the implications on drug release. For the first time, USAC has been successfully employed for manufacturing elastic thermoplastic polyurethanes-based matrices. TPU tablets show an inert character with a sustained drug release governed by a diffusional mechanism. Initial porosity of matrices was similar in all batches studied, with no influence of drug particle size, and a fractal nature of the pore network has been observed. SEM microphotographs show the continuum medium created by the sintering of the polymer, responsible for the high excipient efficiency.

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Section: Resultssupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Achieving High Excipient Efficiency with Elastic Thermoplastic Polyurethane by Ultrasound Assisted Direct Compression

2019

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“…Another approach to prolonging the action of orally applied chelating therapeutics is a sustained release oral formulation, as demonstrated on deferiprone [149].…”

Section: Polymers With Bound Chelators To Be Applied Orallymentioning

confidence: 99%

Chelators for Treatment of Iron and Copper Overload: Shift from Low-Molecular-Weight Compounds to Polymers

et al. 2021

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Iron and copper are essential micronutrients needed for the proper function of every cell. However, in excessive amounts, these elements are toxic, as they may cause oxidative stress, resulting in damage to the liver and other organs. This may happen due to poisoning, as a side effect of thalassemia infusion therapy or due to hereditary diseases hemochromatosis or Wilson’s disease. The current golden standard of therapy of iron and copper overload is the use of low-molecular-weight chelators of these elements. However, these agents suffer from severe side effects, are often expensive and possess unfavorable pharmacokinetics, thus limiting the usability of such therapy. The emerging concepts are polymer-supported iron- and copper-chelating therapeutics, either for parenteral or oral use, which shows vivid potential to keep the therapeutic efficacy of low-molecular-weight agents, while avoiding their drawbacks, especially their side effects. Critical evaluation of this new perspective polymer approach is the purpose of this review article.

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“…3,[15][16][17] The same was compared to the formulation containing HPMC in the same amount. Matrix rutin tablets (10 mg dose) were prepared by direct compression method.…”

Section: Matrix Tablet Preparationmentioning

confidence: 99%

Adenanthera pavonina galactomannan for controlled delivery of rutin – a preliminary study

Nobre¹,

Soares²,

Vieira³

et al. 2018

Quim. Nova

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publicado na web em 04/04/2018Improving the development of modified release matrix systems strictly depends on selecting an appropriate agent capable of controlling the drug's release. In this study, Adenanthera pavonina galactomannan was investigated as a potential basis for developing a controlled release of rutin. This galactomannan was extracted, purified and characterized by GPC, NMR and FT-IR spectroscopy. C DEPT 135º NMR and HSQC spectra). The sustained-release tablets containing rutin and galactomannan were compared with the extensively investigated hydrophilic matrix HPMC. Drug release analysis revealed similar release mechanism for both matrices. A new formulation for controlled drug delivery from water-swellable matrix systems is proposed.

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A new deferiprone controlled release system obtained by ultrasound-assisted compression

Cited by 9 publications

References 23 publications

Achieving High Excipient Efficiency with Elastic Thermoplastic Polyurethane by Ultrasound Assisted Direct Compression

Achieving High Excipient Efficiency with Elastic Thermoplastic Polyurethane by Ultrasound Assisted Direct Compression

Chelators for Treatment of Iron and Copper Overload: Shift from Low-Molecular-Weight Compounds to Polymers

Adenanthera pavonina galactomannan for controlled delivery of rutin – a preliminary study

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