A new cyclic lipopeptide isolated from Bacillus amyloliquefaciens HAB-2 and safety evaluation

Jin, Pengfei; Wang, Haonan; Liu, Wenbo; Fan, Yongmei; Miao, Weiguo

doi:10.1016/j.pestbp.2017.08.015

Cited by 23 publications

(10 citation statements)

References 22 publications

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“…RhoB-crotamine, a defensin-like cationic peptide that displays cell-penetrating, antitumor, antimicrobial, antifungal, and antiparasitic properties at low micromolar range, was lethal to zebrafish embryos at all concentrations assayed (0.25–1.0 μM) [38]. In a recent safety study of the cyclic lipopeptide bacillomycin DC, the LC 50 value after 96 h of exposure was 22.2 μg/mL [56]. In this case, the estimated lethal dose 50 (LD 50 ) value was between 3 and 6 µM, and the maximum tolerated dose (MTD) was 1.39 µM.…”

Section: Discussionmentioning

confidence: 99%

Preclinical studies of toxicity and safety of the AS-48 bacteriocin

Cebrián

Rodríguez-Cabezas

Martín‐Escolano

et al. 2019

Journal of Advanced Research

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Section: Discussionmentioning

confidence: 99%

Preclinical studies of toxicity and safety of the AS-48 bacteriocin

Cebrián

Rodríguez-Cabezas

Martín‐Escolano

et al. 2019

Journal of Advanced Research

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“…The lipopeptides synthesized by B. amyloliquefaciens HAB-2 were reported to show low toxicity levels to aquatic species, indicating that they do not suppose a safety hazard. 105,106 Acute oral toxicity test demonstrated that B. amyloliquefaciens S20 and LN2 exerted no harmful effects on the relative organ weights, morphological tissue structure, and health of mice. 107 As far as we know, no articles related to the potential toxicity of B. velezensis, B. nakamurai, and B. siamensis strains were reported to date, indicating that there is an important gap in this regard.…”

Section: Toxicity To Humansmentioning

confidence: 99%

Biocontrol Ability of the Bacillus amyloliquefaciens Group, B. amyloliquefaciens, B. velezensis, B. nakamurai, and B. siamensis, for the Management of Fungal Postharvest Diseases: A Review

Wang

Herrera‐Balandrano

Wang

et al. 2022

J. Agric. Food Chem.

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The Bacillus amyloliquefaciens group, composed of B. amyloliquefaciens, B. velezensis, B. nakamurai, and B. siamensis, has recently emerged as an interesting source of biocontrol agents for the management of pathogenic fungi. In this review, all the reports regarding the ability of these species to control postharvest fungal diseases have been covered for the first time. B. amyloliquefaciens species showed various antifungal mechanisms, including production of antifungal lipopeptides and volatile organic compounds, competition for nutrients, and induction of disease resistance. Most reports discussed their use for the control of fruit diseases. Several strains were studied in combination with additives, improving their inhibitory efficacies. In addition, a few strains have been commercialized. Overall, studies showed that B. amyloliquefaciens species are a suitable environmentally friendly alternative for the control of postharvest diseases. However, there are still crucial knowledge gaps to improve their efficacy and host range.

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“…A distinct difference between surfactin and iturin is that the latter has a cyclic closure of the lipopeptide structure by a beta-amino group of the fatty acid (Aleti et al 2015). Other lipopeptides belonging to the iturin family and produced by Bacillus species include bacillomycin D (Gong et al 2014;Gu et al 2017), bacillomycin DC (Jin et al 2017) and mycosubtilin (Deravel et al 2014). Fengycin's structure contains a cyclic lactone ring, comprised of a fatty acid chain linked to a decapeptide.…”

Section: Cyclic Lipopeptidesmentioning

confidence: 99%

Microbial metabolomics: essential definitions and the importance of cultivation conditions for utilizing Bacillus species as bionematicides

Horak

Engelbrecht

Rensburg

et al. 2019

J of Applied Microbiology

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Root‐knot nematodes are destructive phytopathogens that damage agricultural crops globally, and there is growing interest in the use of biocontrol based on rhizobacteria such as Bacillus to combat Meloidogyne species. It is hypothesized that nematicidal activity of Bacillus can be attributed to the production of secondary metabolites and hydrolytic enzymes. Yet, few studies have characterized these metabolites and their identities remain unknown. Others are speculative or fail to elaborate on how secondary metabolites were detected or distinguished from primary metabolites. Metabolites can be classified based on their origin as either intracellular or extracellular and based on their function, as either primary or secondary. Although this classification is in general use, the boundaries are not always well defined. An understanding of the secondary metabolite and hydrolytic enzyme classification of Bacillus species will facilitate investigations aimed at bionematicide development. This review summarizes the significance of Bacillus hydrolytic enzymes and secondary metabolites in bionematicide research and provides an overview of known classifications. The importance of appropriate cultivation conditions for optimum metabolite and enzyme production is also discussed. Finally, the use of metabolomics for the detection and identification of nematicidal compounds is considered.

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A new cyclic lipopeptide isolated from Bacillus amyloliquefaciens HAB-2 and safety evaluation

Cited by 23 publications

References 22 publications

Preclinical studies of toxicity and safety of the AS-48 bacteriocin

Preclinical studies of toxicity and safety of the AS-48 bacteriocin

Biocontrol Ability of the Bacillus amyloliquefaciens Group, B. amyloliquefaciens, B. velezensis, B. nakamurai, and B. siamensis, for the Management of Fungal Postharvest Diseases: A Review

Microbial metabolomics: essential definitions and the importance of cultivation conditions for utilizing Bacillus species as bionematicides

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