A New Coumestan from Tephrosia calophylla.

Kishore, Pennaka Hari; Reddy, Mopur Vijaya Bhaskar; Gunasekar, Duvvuru; Murthy, M. Marthanda; Caux, Cristelle; Bodo, Bernard

doi:10.1248/cpb.51.194

Cited by 42 publications

(11 citation statements)

References 4 publications

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“…The different sugar moieties of 7 and 8 were further identified as glucose and rutinose respectively according to their 1 H and 13 C NMR. On the basis of the above analysis, they were identified as kaempferol 3-O-β-D-glucopyranoside ( 7 ) [34] and kaempferol 3-O-β-D-rutinoside ( 8 ) [35] respectively.…”

Section: Resultsmentioning

confidence: 99%

Antidiabetic and Antioxidant Effects and Phytochemicals of Mulberry Fruit (Morus alba L.) Polyphenol Enhanced Extract

et al. 2013

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The antidiabetic and antioxidant activities of the ethyl acetate-soluble extract (MFE) of mulberry fruit (Morus alba L.) were investigated. In vitro, MFE showed potent α-glucosidase inhibitory activity and radical-scavenging activities against DPPH and superoxide anion radicals. In vivo, MFE could significantly decrease fasting blood glucose (FBG) and glycosylated serum protein (GSP), and increase antioxidant enzymatic activities (SOD, CAT, GSH-Px) in streptozotocin (STZ)-induced diabetic mice. Bioactivity-guided fractionation of the MFE led to the isolation of 25 phenolic compounds, and their structures were identified on the basis of MS and NMR data. All the 25 compounds were isolated from mulberry fruit for the first time. Also, the α-glucosidase inhibitory activity and antioxidant activity of the phenolics were evaluated. Potent α-glucosidase inhibitory and radical-scavenging activities of these phenolics suggested that they may be partially responsible for the antidiabetic and antioxidant activities of mulberry fruit.

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Section: Resultsmentioning

confidence: 99%

Antidiabetic and Antioxidant Effects and Phytochemicals of Mulberry Fruit (Morus alba L.) Polyphenol Enhanced Extract

et al. 2013

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“…Our subsequent phytochemical research on the 80% EtOH extract, which showed antioxidant activity by DPPH, has led to the isolation of nine known flavonol glycosides, myricetin 3- O -β-D-xylopyranosyl(1→2)-β-D-glucopyranoside ( 1 ) [ 20 ], myricetin 3- O -rutinoside ( 2 ) [ 21 ], myricetin 3- O -β-D-glucopyranoside ( 3 ) [ 22 ], quercetin 3- O -β-D-xylopyranosyl(1→2)-β-D-glucopyranoside ( 4 ) [ 22 ], laricitin 3- O -β-D-glucopyranoside ( 6 ) [ 23 ], kaempferol 3- O -β-D-xylopyranosyl(1→2)-β-D-glucopyranoside ( 7 ) [ 24 ], myricetin 3′- O -β-D-glucopyranoside ( 8 ) [ 11 ], kaempferol 3- O -β-D-glucopyranoside ( 10 ) [ 25 ], and complanatuside ( 11 ) [ 26 ], one isoflavone glycoside 3′-hydroxy-4′-methoxyisoflavone-7- O -β-D-glucopyranoside ( 5 ) [ 27 ], and a decadien derivative, (2 E ,4 E )-8-hydroxy-2,7-dimethyl-decadien-(2,4)-disaeure-(1,10)-dioic acid ( 9 ) [ 28 ]. The structures of all isolated compounds were identified by extensive spectroscopic methods including MS and 2D NMR and comparison with the reported data.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Flavonoid Glycosides and HPLC and UPLC Quantification of Commercial Astragali Complanati Semen

et al. 2020

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Eleven compounds, including nine known flavonoid glycosides (1–4, 6–8, and 10–11), one isoflavone glycoside (5), and a glansreginic acid (9), were isolated from the 80% ethanol extract of commercial Astragali Complanati Semen (ACS). All chemical structures were determined by spectroscopic analyses, including 1D and 2D NMR. Compounds 2, 4, 5, 6, 9, and 10 were isolated and identified from the title plant for the first time. Biological evaluation revealed that all the isolates showed promising anti-NO production, and 1, 2, 3, and 8 were more potent in antioxidant activity than vitamin E. The major peaks in the UPLC and HPLC profiles identified their chemical structures by comparing their retention time and UV spectra with those of the reference substances. Furthermore, nine of the eleven samples collected from North, Middle, and South regions of Taiwan possessed similar HPLC fingerprints and were identified as Astragali Complanati Semen, whereas the other two samples from southern Taiwan would be the adulterants due to the different fingerprinting patterns. In addition, an HPLC-UV method was employed to determine the content of target compound complanatuside (11) with good linear regression (R2 = 0.9998) for ACS in the Taiwanese market. Of the isolates, flavonol glycosides 1 and 3 were the major peaks in HPLC/UPLC, and showed more potent antioxidant and anti-NO production activities than that of 11, revealing that these compounds can be the available agents for the quality control of ACS.

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“…Forty-two isoflavones, 94 – 13 5 , have been isolated and identified from this genus [5,22,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91]. Among them, 111 – 125 were identified as rotenoids [74,75,76,77,78,79,80,81,82], 94 and 126 – 13 5 were identified as coumestan derivatives [22,83,84,85,86,87,88,89,90,91].…”

Section: Chemical Constituentsmentioning

confidence: 99%

Natural Products from the Genus Tephrosia

et al. 2014

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Abstract:The genus Tephrosia, belonging to the Leguminosae family, is a large pantropical genus of more than 350 species, many of which have important traditional uses in agriculture because they possess the bioactivity of phytoalexins. This review not only outlines the sources, chemistry and biological evaluations of natural products from the genus Tephrosia worldwide that have appeared in literature from 1910 to December 2013, but also covers work related to proposed biosynthetic pathways and synthesis of some natural products from the genus Tephrosia, with 105 citations and 168 new compounds.

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A New Coumestan from Tephrosia calophylla.

Cited by 42 publications

References 4 publications

Antidiabetic and Antioxidant Effects and Phytochemicals of Mulberry Fruit (Morus alba L.) Polyphenol Enhanced Extract

Antidiabetic and Antioxidant Effects and Phytochemicals of Mulberry Fruit (Morus alba L.) Polyphenol Enhanced Extract

Bioactive Flavonoid Glycosides and HPLC and UPLC Quantification of Commercial Astragali Complanati Semen

Natural Products from the Genus Tephrosia

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