A new clerodane diterpene from Teucrium polium L.

Abstract

The structure of a clerodane-6,7-dione (Z), isolated from Teucrium polium L., has been established, and related to that of the corresponding 7-hydroxy-6-ketone picropolin (3). The stereostructures of (2) and (3) are tentatively assigned.THE diterpene content of T. polium has been investigated previously; picropolin (3), a diterpene of the clerodane type, was reported as the main component. A reinvestigation of this plant, collected at Arganda (Madrid), was undertaken with the primary aim of isolating this compound. Since the actual content of our plant material differs considerably from that reported, we now describe our results, Three diterpenes were isolated. The lH n.m.r. " CH,OAC ia ( 1 ) R' =H,H, R ~= O (2) R ' = O J R2=O

Evaluation of Limonoids Against the Murine P388 Lymphocytic Leukemia Cell Line

“…Some indication that the D-ring lactone and furan ring systems are not essential for retarding growth of the PS cell line was obtained by evaluating a series (39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50) of naturally occurring furans (table 2) found in several other plant families. All (including 5We have observed an analogous situation with PS in vitro active pseudoguaianolides such as autumnolide, and the need for two ,ß-unsaturated systems with related substances such as helenalin and radiatin.…”

HPLC and UV-spectrophotometry analysis of flavonoids in spray-dried and freez-dried extracts of Teucrium polium L. (Lamiaceae)

“…Even so, there is a presence of different classes of secondary metabolites, such as diterpenes (Malakov and Papanov, 1983;Marquez and Valverde, 1979), essential oil (Cozzani et al, 2005;Moghtader, 2009;Kabouche et al, 2007), phenylethanoid glycosides (Oganesyan et al,1991), etc, probably the most important group of compounds in T. polium are the flavonoids. Mainly, flavone glycosides with Maced.…”

Seasonal variation of flavonoids in Teucrium polium L. (Lamiaceae)

“…Some biological and therapeutic effects have been reported for the plant such as antioxidant (Esmaeili et al, 2009;Ardestani et al, 2008), antiinflammatory (Tariq et al, 1989;Capasso et al, 1983), antinociceptive (Baluchnejadmojarad et al, 2005;Abdollahi et al, 2003), antipyretic (Aggelis et al, 1998;Autore et al, 1984), anti-microbial (Autore et al, 1984), hypolipidemic (Rasekh et al, 2001), hepatopro-tective (Panovska et al, 2007), cytotoxic and apoptotic effects (Rajabalian et al, 2008). The plant poses complex chemical composition with presence of new clerodane type diterpenes (Malakov and Papanov, 1983;Marquez and Valverde, 1979), essential oil with dominating sesquiterpene alcohols and pinenes (Cozzani et al, 2005;Moghtader, 2009;Kabouche et al, 2007), phenylethanoid glycosides such as verbascoside and poliumoside (Oganesyan et al,1991), flavone glycosides with highly methylated aglycons (Verykokidou-Vitsaropoulou and Vajias, 1986;Rizk et al, 1986;Kawashty et al, 1999;Harborne et al, 1986;Sharififar et al, 2009), etc. Flavonoids are representing the most important group of active components of Teucrium species, and many of the activities of these plants are attributed to the flavonoid class of secondary metabolites. It is also well known that the composition and the content of the flavonoids in plant material could be variable depending of the season, location and environmental condition of plant growth as well as the influence of other different factors (Liu et al, 1994;De Castro, et al, 2006;Bagdonaite et al, 2009).…”