A new class of quaternary ammonium compounds as potent and environmental friendly disinfectants

Wang, Guodong; Yang, Ling; Jiang, Ling; Chen, Jingyi; Jing, Qian; Mai, Yuhan; Deng, Lina; Yang, Lin; Chen, Liyun; Chen, Zheng; Xu, Peng; Jiang, Longguang; Yuan, Cai; Huang, Mingdong

doi:10.1016/j.jclepro.2022.134632

Cited by 16 publications

(7 citation statements)

References 57 publications

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“…Bunge [21], which is commonly used for treating cardiovascular diseases in Chinese Traditional Medicine.The chemical formula consists of three tanshinol molecules and one caffeic acid molecule [22]. It has antioxidant properties because of the structure contains multiple phenolic hydroxyls [23]. Our previous experimental results showed that Sal B exhibited potential protective effect on myocardial fibrosis induced by DCM.…”

Section: Salvinolic Acid B (Sal B) Is a Phenolic Compound Found In Sa...mentioning

confidence: 99%

Salvianolic Acid B (Sal B) ameliorates myocardial fibrosis in diabetic cardiomyopathy through deubiquitinating Smad7

Luo,

Fu,

Wang

et al. 2023

Preprint

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Background Salvianolic acid B (Sal B), a water-soluble phenolic compound derived from Salvia Miltiorrhiza Bunge, is commonly used in Chinese Traditional Medicine for the treatment of cardiovascular diseases. Sal B has shown protecting effects against myocardial fibrosis induced by diabetic cardiomyopathy(DCM) in our previous experiment. This study aimed to investigate the ameliorative effects and potential mechanisms of Sal B in mitigating myocardial fibrosis induced by DCM. Methods In this study, a variety of methods were utilized to investigate the effects of Sal B on improving myocardial fibrosis induced by DCM in vivo and in vitro. These methods included weight measurement, blood glucose analysis, echocardiography, HE staining, Masson's trichrome staining, Sirius red staining, cell proliferation assessment, determination of hydroxyproline levels, immunohistochemical staining, evaluation of fibrosis-associated protein expression (Collagen I, Collagen III, TGF-β1, p-Smad3, Smad3, Smad7, and α-smooth muscle actin), analysis of Smad7 gene expression, and analysis of Smad7 ubiquitin modification. Results The animal test results indicated Sal B could significantly improve cardiac function, inhibit collagen deposition and phenotypic transformation, ameliorate myocardial fibrosis in DCM by up-regulating Smad7, thereby inhibiting TGF-β1 signaling pathway. Additionally, cell experiments demonstrated Sal B could significantly inhibit the proliferation, migration, phenotypic transformation and collagen secretion of cardiac fibroblasts (CFs) induced by high glucose(HG). Sal B could significantly decrease the ubiquitization modifications of Smad7, stabilize the protein expression of Smad7, therefore increase the protein expression of Smad7 in the CFs , inhibit TGF-β1 signaling pathway, that maybe a potential mechanism of Sal B in mitigating myocardial fibrosis induced by DCM. Conclusion In summary, this study revealed that Salvianolic acid B can improve myocardial fibrosis in DCM by deubiquitinating Smad7, stabilizing the protein expression of Smad7, blocking the TGF-β1 signaling pathway.

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Section: Salvinolic Acid B (Sal B) Is a Phenolic Compound Found In Sa...mentioning

confidence: 99%

Salvianolic Acid B (Sal B) ameliorates myocardial fibrosis in diabetic cardiomyopathy through deubiquitinating Smad7

Luo,

Fu,

Wang

et al. 2023

Preprint

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“…Despite the fact that there is still no exact definition of the term “environmental friendly disinfectants”, it has been generally accepted that disinfectants being relatively safe to the environment are mainly characterized by the following two aspects. On the one hand, an environmental friendly disinfectant can be fast degraded in the environment and its degraded residuals are non-toxic to organisms ( 5 , 12 ). Among the common chemical disinfectants, the hydrogen peroxide would readily break down into oxygen and hydrogen within a short period under natural conditions, thus highly unstable in environment ( 3 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

“…Based on their high likelihood of quickly evaporating following application, the volatile disinfectants such as alcohols, bromochloromethane, bromoethane, and chlorine dioxide are unlikely to reach the environmental matrices ( 3 ). In recent years, some novel eco-friendly chemical disinfectants, such as phthalocyanin-substituted ammonium compound ( 12 ), acidic electrolyzed water ( 13 ), commercially available disinfectants Benefect ® ( 14 ) and Clyraguard copper iodine complex ( 15 ), etc., have been developed and demonstrated to be effective for pathogen inactivation, more importantly, not to cause secondary hazard to the environment after administration. On the other hand, more and more researchers focus interest on the development of natural green disinfectants extracted from natural herbs and microorganisms, as the safer and reliable alternatives to the toxic chemical disinfectants for health and the environment ( 16 , 17 ).…”

Section: Introductionmentioning

confidence: 99%

Knowledge, attitudes and practice regarding environmental friendly disinfectants for household use among residents of China in the post-pandemic period

Tong

Zhu

Chen

et al. 2023

Front. Public Health

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BackgroundA sharp rise in household consumption of disinfectants triggered by COVID-19 pandemic has generated tremendous environmental burden and risks of disinfectant emissions in the post-pandemic period. To address this emerging challenge, replacing highly hazardous disinfectants with more environmental friendly alternatives has been accepted as an inherently effective solution to environment issues posed by disinfectant emerging contaminants. However, no study has yet been done to explore the potential customers' attitudes and the market prospect of environmental friendly disinfectants until now.MethodsThis cross-sectional questionnaire-based survey was conducted from January to March, 2022, among resident volunteers in China, to explore the practices, knowledge and attitudes of the public regarding environmental friendly disinfectants for household use.ResultsAmong a total of 1,861 Chinese residents finally included in the analyses, 18% agreed or strongly agreed that they paid special attention to the environmental certification label on the product, and only bought the environmental certified disinfectant products; 16% and 10% were using environmental friendly disinfectants for hand sanitization and environmental disinfection, respectively. The mean self-assessed and actual knowledge scores were 2.42 ± 1.74 and 2.12 ± 1.97, respectively, out of a total of 5. Participants having good practices of consuming environmental friendly disinfectants achieved higher knowledge scores. Residents' overall attitudes toward the development, consumption and application of environmental friendly disinfectants were very positive. “Possible conflict between disinfection effectiveness and environmental factor of disinfectants in a context of severe COVID-19 pandemic” was considered as the most important barrier jeopardizing the participants' usage intention for environmental friendly disinfectants.ConclusionsThese data suggested most residents of China had a positive attitude, poor knowledge and practices toward environmental friendly disinfectants. More should be done to enhance the residents' environmental knowledge levels about disinfectants, and to further develop and promote disinfectant products with both excellent disinfection activity and environmentally friendly attributes.

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“…Under those circumstances, disinfectants are commonly used in hospitals, industries, and households, which play a pivotal role on epidemic prevention and control . Quaternary ammonium salts (QASs) are one of the most favorable and effective classes of disinfectants due to their excellent antibacterial activity, relatively low toxicity, easy preparation, and low price. , …”

Section: Introductionmentioning

confidence: 99%

“…2 Quaternary ammonium salts (QASs) are one of the most favorable and effective classes of disinfectants due to their excellent antibacterial activity, relatively low toxicity, easy preparation, and low price. 3,4 With the lucubrating of research, the development of modern QASs has been in rapid progress over the past 2 decades. The types of cations have evolved from the simplest alkyl chain to diverse organic skeleton, and the change of the anions has also varied from halogen ions to other inorganic anions, such as hydrogen sulfate, tetrafluoroborate, hexafluorophosphate, etc.…”

Section: ■ Introductionmentioning

confidence: 99%

Highly Effective and Broad-Spectrum Antimicrobial Quaternary Ammonium Salts Containing Camphene Structure: Preparation, Surface-Active Properties, and Bioassay

Huang,

Huo,

et al. 2023

ACS Omega

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A series of novel quaternary ammonium salts (QASs) (4a–4n) comprising a camphene moiety were synthesized for the first time. Fourteen examples were prepared from camphene through Prins reaction, halogenation, and quaternarization, successively. The structures of the synthesized QASs were analyzed by Fourier transform infrared spectroscopy, 1H NMR, 13C NMR and high-resolution mass spectrometry. Surface-active properties, emulsifying abilities, and foaming properties of the investigated compounds were then studied. The antimicrobial activities of these QASs against Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis), Gram-negative bacteria (Escherichia coli and Klebsiella pneumoniae), and fungi species (Candida albicans, Candida tropicalis, and Aspergillus niger) were determined by the microdilution method. The results showed that the chemical structural factors, including types of substitutes and alkyl chain length, might be correlated with the lipid–water partition coefficient (cLog P), which played a critical role in the antimicrobial process. Compounds with alkyl chain lengths (N) in the range of 10–14 were relatively more active, while compounds bearing pyridinium, benzyl, methylimidazolium groups, or varied alkyl chain lengths (N < 5 and N > 16) were almost inactive. Compound 4k possessing a dodecyl group exhibited the most effective and broad-spectrum antimicrobial activity against almost all tested bacteria and fungi with the minimal inhibitory concentration values ranging from 0.24 to 0.98 μg/mL.

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A new class of quaternary ammonium compounds as potent and environmental friendly disinfectants

Cited by 16 publications

References 57 publications

Salvianolic Acid B (Sal B) ameliorates myocardial fibrosis in diabetic cardiomyopathy through deubiquitinating Smad7

Salvianolic Acid B (Sal B) ameliorates myocardial fibrosis in diabetic cardiomyopathy through deubiquitinating Smad7

Knowledge, attitudes and practice regarding environmental friendly disinfectants for household use among residents of China in the post-pandemic period

Highly Effective and Broad-Spectrum Antimicrobial Quaternary Ammonium Salts Containing Camphene Structure: Preparation, Surface-Active Properties, and Bioassay

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