A New Class of Boronic Acid‐Derived Amphiphile‐Based Gel Emulsions Capable of Entrapping and Releasing Vitamin B₁₂ and Doxorubicin

Abstract

In this work, two boronic acid based amphiphiles, Sodium salt of 2-amidodecylpyridine-5-boronic acid (SADPB) and Sodium salt of 2-amidododecylpyridine-5-boronic acid (SADDPB) have been synthesized and their gel-emulsion property in organic solvents were investigated. The good gelation ability of the amphiphiles was confirmed by low minimum gelation concentration (MGC) and high gelation number (N gel ) values. Theoretical study established that introduction of amide linkage in the amphiphilic structure dismantles aggregate formation. The gelemulsions are stable towards mechanical and thermal re-sponses. The gelation process is also dependent on the nature of solvent and type of amphiphiles. The morphology of gelemulsions is highly dependent on the concentration of the amphiphile. The prepared gel-emulsions are able to encapsulate and release biomolecule vitamin B 12 and anticancer drug doxorubicin at room temperature. Both vitamin B 12 and doxorubicin exhibited retention of their structures and activity which has been recognized this new type of boronic acid based amphiphiles as efficient drug delivery vehicles.[a] Dr.

Nonionic Glycolipids for Chromium Flotation- and Emulsion (W/O and O/W)-Based Bioactive Release

“…The maximum G ′ and G ″ independent frequency values of the glycolipid emulsions are shown in Table . From this, the increasing order of tolerance to the external force of glycolipid emulsions is 2a-3 < 1c-3 < 2b-3 < 2a-1 < 1c-1 < 2b-1 ∼ 2c-9 < 2c-7 < 2c-5 < 2c-3 . This indicates that with an increase in ϕ w value the tolerance to the external force of each glycolipid emulsion was decreased.…”

“…Generally, the emulsion droplet size has a linear relationship with emulsion stability . Here, DLS and CLSM experiments were employed to measure the emulsion droplet size. , The multiple scattering effect in DLS measurements of emulsion samples was reduced by dilution with sunflower oil when ϕ w ≤ 5 and dilution with water when ϕ w > 5. Obtained droplet size distributions of the emulsions and corresponding average droplet sizes are shown in Table and Figure S3, respectively.…”

“…The tolerance performance of Y a glycolipids increased significantly with an increase in alkyl chain length at ϕ w = 3 ( 2a-3 < 2b-3 < 2c-3 ). To obtain an oscillatory shear strain data, a strain sweep experiment was performed at a constant frequency (1 Hz) . The strain sweep experiments of the emulsions are shown in Figure S5, and critical strain values (%) are tabulated in Table .…”

“…At a ϕ w value of 1, glycolipids 1c, 2a, and 2b form gel emulsions, and they were confirmed by the tube inversion method (Figure 4). 38 Furthermore, at 25 °C, insoluble hydrophobic glycolipid 2c was able to produce hydrogel by the heating−cooling method; at ϕ w value 3−9, glycolipid 2c formed stable gel emulsions, and at ϕ w value 1, glycolipid 2c showed precipitation. In the case of glycolipids 3b and 3c, a stable oil-in-water phase was observed when the ϕ w value <3.…”

“…Furthermore, water-in-oil emulsions are useful in encapsulating and controlled release of water-soluble bioactives . For pharmaceutical applications, physical encapsulation and release of bioactives from the formulation are the important features. ,− …”