A new chlorinated diphenyl ether and five known polyketide metabolites from Penicillium griseofulvum cib-119

Abstract

A series of polyketide metabolites (1-6), including a new chlorinated diphenyl ether (4-chloro-7,4'-dihydroxy-5,2'-dimethoxy-2-methylformate-6'-methybenzophone, 1), were isolated from the solid-fermented rice culture of Penicillium griseofulvum cib-119. The structure of compound 1 was determined on the basis of NMR spectra and single-crystal X-ray diffraction analyses. In addition, compound 1 showed weak cytotoxic activity against prostatic carcinoma cell (PC-3). Compounds 3-5 exhibited significant antimicrobial activities against Staphylococcus aureus and Bacillus subtilis.

Fungal Community Investigation from Propolis Natural Products: Diversity and Antibacterial Activities Evaluation

“…Among these strains, P. griseofulvum CC8 revealed the strongest inhibitory effects against all the tested bacteria ( Figure 3(b) ). As previously described, P. griseofulvum has been shown to be a rich source of interesting bioactive products with diverse features including griseofulvin derivatives and indole alkaloids exhibiting anti-HIV activities [ 68 ], Penifulvin A with antiinsect activity [ 69 ], polyketide metabolites displaying antitumoral activity against prostatic carcinoma cells (PC-3), and penigrisacid D , which proved cytotoxicity against ECA-109 tumor cells and particularly antimicrobial activities against Staphylococcus aureus and Bacillus subtilis [ 70 , 71 ]. The genus Coniochaeta , too, is well known for its antimicrobial capabilities.…”