A new chemical mutagen for bacteria, 1-methyl-3-nitro-1-nitrosoguanidine

ACTION OF N-METHYL-N'-NITRO-N-NITROSOGUANIDINE IN <i>BACILLUS SUBTILIS</i>

“…It was observed by several investigators (Mandell et al 1960, Eisenstarck et al 1965and Adelberg et al 1965) that nitrosoguanidine induced mutation efficiently in the low lethal dose range.…”

“…potent mutagen in the field of microbial genetics, since Mandell and Greenberg (1960) discovered its mutagenicity.…”

Chemical Mutagens

“…As previously suggested, only those agents are included in which induction has been demonstrated by appropriate plating techniques with an indicator strain. The degree of prophage induction is indicated in general terms of "potent" (P), "moderately Allan and McCalla (1966); Mandell and Greenberg (1960); ; Greene andGreenberg (1960) Menzel andGeissler (1966); Marquardt et at. (1964) Menzel andGeissler (1966); Marquardt et al (1964) + ; Bird and Fahmy (1953); McCammon et al (1957); Rose et al (1950) Field andNaylor (1962); Kolmark (1956); Druckrey et al (1966) + ; Davies et al (1960) Field andNaylor (1962); Smith and Srb (1951); Palmes et al (1962) +a Endo et al (1963a); Okaboyashi et al (1965); ; Moore et at.…”

Elimination of F-Episome From a Male Strain of Escherichia Coli by Treatment With Sarkomycin and a Related Antibiotic

“…Acridine dyes (15) and NG (16) are mutagenic, and the latter is anti-tumor, too (17). As far as the experimental methods reported in the previous paper (18) are concerned, sarkomycin is not mutagenic or phage-inducing.…”