Elimination of F-Episome From a Male Strain of Escherichia Coli by Treatment With Sarkomycin and a Related Antibiotic

Ikeda, Yōnosuke; Iijima, Tadako; Tajima, Kuniko

doi:10.2323/jgam.13.247

Cited by 8 publications

(1 citation statement)

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“…These drug-resistance determinants are transmissible to sensitive bacteria independently of chromosomal genes and like the sex factor they can be eliminated by acridine dyes, but generally at low frequencies. Recently, Ikeda, Iijima & Tajima (1967) reported that the sex factor in a male strain of Escherichia coli K12 was eliminated by sarkomycin, which was however less active than acridine orange. Elimination of antibiotic resistance at high frequency is of interest to assert extrachromosomal location of genetic determinants, and drugs with better eliminating or 'curing' effect are needed.…”

Section: Many Genetic Determinants Of Antibiotic Resistance In Enteromentioning

confidence: 99%

Elimination by Ethidium Bromide of Antibiotic Resistance in Enterobacteria and Staphylococci

Bouanchaud

Scavizzi

Chabbert

1968

Journal of General Microbiology

262

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SUMMARYEthidium bromide, a trypanocidal drug affecting nucleic acid synthesis, was found to be a powerful agent in eliminating some antibiotic resistance in bacteria. In staphylococci, penicillinase production was eliminated in mercury-resistant organisms, but not in mercury-sensitive ones. Among enterobacteria, two resistance factors showing the same resistance pattern were differently eliminated, and correlation between elimination and transfer of resistance factors was not always observed. F'-lac+ factor was also eliminated by ethidium bromide in Escherichia coli ~1 2 .Elimination of antibiotic resistance was observed generally at high frequency, and could be better reproduced than with acridine dyes.

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Section: Many Genetic Determinants Of Antibiotic Resistance In Enteromentioning

confidence: 99%