A new cause of ischaemic priapism: Synthetic cannabinoids

Abstract

Priapism is a urological emergency that needs early intervention and may lead to irreversible cavernosal damage. Ischaemic priapism is the most common type, which is frequently idiopathic and commonly associated with haematological diseases, medications or recreational drugs. Synthetic cannabinoids (SCs) have been increasingly used all over the world, particularly among young-adult population. SCs can cause severe adverse effects on several organ systems. However, there are no studies in the literature which have stated the possible relationship between using of SCs and priapism. We present a case of 28-year-old man who was diagnosed with a 58-hr lasting priapism after regular administrations of SCs. The priapism did not resolve neither after applying aspiration with irrigation nor shunt surgery. Finally, penile prosthesis implantation was performed as last treatment option. The SCs have been increasingly used among young population in recent years; therefore, new SC-related ischaemic priapism cases might be encountered in the emergency departments.

Recurrent priapism in the setting of cannabis use

“…Further, his history exhibited a convincing correlation between his cannabis use and his episodes of recurrent priapism. Because cannabis is the most widely used illicit substance, its link to priapism suggests it may soon become more prominent within the emergency department (Ortac et al, 2018).…”

“…The fourth case report notes concurrent insulin dependent diabetes mellitus, cocaine use, and anabolic steroid use, with cocaine and diabetes each previously described causes of priapism (Evans et al, 2016). An additional report gives supporting evidence that synthetic cannabinoids, which are 100 times more potent activators of the same cannabinoid type 1 receptor (CB1R) as THC, can cause priapism (Ortac et al, 2018;Wiley et al, 2014). If synthetic cannabinoids can cause priapism, plant cannabis, affecting the same CB1R, would also be capable to potentiate this reaction.…”

Sexual experiences between partners after penile prosthesis: Who is more satisfied?

“…Early penile prosthesis application is a good option especially in ischaemic priapismus irresponsive to other treatments (Ortac, Pazır, & Kadıoğlu, 2018;Yücel, Pazır, & Kadıoğlu, 2018;Zacharakis et al, 2014). While the satisfaction ratio was 96% in patients who were applied early PPI, it was found as 60% in late PPI-applied patients.…”

“…While the satisfaction ratio was 96% in patients who were applied early PPI, it was found as 60% in late PPI-applied patients. Early penile prosthesis application is a good option especially in ischaemic priapismus irresponsive to other treatments (Ortac, Pazır, & Kadıoğlu, 2018;Yücel, Pazır, & Kadıoğlu, 2018;Zacharakis et al, 2014).…”

Loxapine-Induced Priapism: A Case Report and Review of the Literature on Antipsychotic-Induced Priapism

“…Medications/substances (i) Amyloidosis [3] (i) Antihypertensives [4] (ii) Diabetes [6] (ii) Antidepressants [4] (iii) Gout [7] (iii) Antipsychotics [4] (iv) Malignancy [7] (iv) Buprenorphine [8] (v) Scorpion sting [3] (v) Cocaine [3] (vi) Sickle cell anemia [9] (vi) Methylphenidate [4] (vii) Spinal cord injury [7] (vii) Synthetic cannabinoids [10] 3 Case Reports in Psychiatry…”